Báo cáo y học: "he miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition" pdf

... polycistron as a potential human oncogene.Nature 2005, 435:828-833.3. Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tom-ida S, Yatabe Y, Kawahara K, Sekido Y, Takahashi T: A polycistronic microRNA ... constructs (a) (b)00.511.522.53APBB2 -A APBB2-BAPBB2-CAPP -A APP-BAPP-CAPP-DBCL2L11 -A BCL2L11-BBCL2L11-CBCL2L11-DBCL2L11-ECCND1 -A CCND1-BCCND1-CCCND1-DCCND2 -A CCND2-BCCNG 2A CCNG2-BCDKN 1A CDKN 1A- BCDKN 1A- CCRK -A CRK-BCUL3 -A CUL3-BCUL3-CCUL3-DDMTF1 -A DMTF1-BE2F1 -A E2F1-BE2F1-CE2F3 -A E2F3-BE2F5 -A EREG -A EREG-BEREG-CEREG-DFOXO 1A- AFOXO 1A- BFOXO 1A- CFOXO 1A- DFOXO 1A- EFOXO 1A- FGAB1 -A HAS2 -A HDAC4 -A HDAC4-BHDAC4-CHDAC4-DHIF1 -A HIF 1A- BIRF1 -A KHDRBS1 -A KHDRBS1-BKPNA2 -A MAP3K8 -A MAP3K8-BMAPK9 -A MYCN -A MYCN-BNCOA3 -A NCOA3-BNCOA3-CNCOA3-DNR 4A3 -A NR 4A3 -BNR 4A3 -CPCAF -A PCAF-CPDGFRA -A PDGFRA-BPDGFRA-CPKD1 -A PKD2 -A PKD2-BPKD2-CPKD2-DPPARA -A PPARA-BPPARA-CPPARA-DPPARA-EPPARA-FPPARA-HPTEN -A RB1 -A RB1-BRB1CC1 -A RB1CC1-BRBBP7 -A RBL1 -A RBL1-BRBL2 -A RBL2-BRBL2-CRNF111SMAD7 -A STAT3 -A STAT3-BSTAT3-CSTAT3-DTIMP2 -A TIMP2-BTIMP2-BTIMP2-CTNXIP -A TNXIP-BTNXIP-CTP53INP1 -A TP53INP1-BTP53INP1-CTP53INP1-DTP53INP1-ETP53INP1-FTP53INP1-GTSG101 -A WEE1 -A Relative ... constructs (a) (b)00.511.522.53APBB2 -A APBB2-BAPBB2-CAPP -A APP-BAPP-CAPP-DBCL2L11 -A BCL2L11-BBCL2L11-CBCL2L11-DBCL2L11-ECCND1 -A CCND1-BCCND1-CCCND1-DCCND2 -A CCND2-BCCNG 2A CCNG2-BCDKN 1A CDKN 1A- BCDKN 1A- CCRK -A CRK-BCUL3 -A CUL3-BCUL3-CCUL3-DDMTF1 -A DMTF1-BE2F1 -A E2F1-BE2F1-CE2F3 -A E2F3-BE2F5 -A EREG -A EREG-BEREG-CEREG-DFOXO 1A- AFOXO 1A- BFOXO 1A- CFOXO 1A- DFOXO 1A- EFOXO 1A- FGAB1 -A HAS2 -A HDAC4 -A HDAC4-BHDAC4-CHDAC4-DHIF1 -A HIF 1A- BIRF1 -A KHDRBS1 -A KHDRBS1-BKPNA2 -A MAP3K8 -A MAP3K8-BMAPK9 -A MYCN -A MYCN-BNCOA3 -A NCOA3-BNCOA3-CNCOA3-DNR 4A3 -A NR 4A3 -BNR 4A3 -CPCAF -A PCAF-CPDGFRA -A PDGFRA-BPDGFRA-CPKD1 -A PKD2 -A PKD2-BPKD2-CPKD2-DPPARA -A PPARA-BPPARA-CPPARA-DPPARA-EPPARA-FPPARA-HPTEN -A RB1 -A RB1-BRB1CC1 -A RB1CC1-BRBBP7 -A RBL1 -A RBL1-BRBL2 -A RBL2-BRBL2-CRNF111SMAD7 -A STAT3 -A STAT3-BSTAT3-CSTAT3-DTIMP2 -A TIMP2-BTIMP2-BTIMP2-CTNXIP -A TNXIP-BTNXIP-CTP53INP1 -A TP53INP1-BTP53INP1-CTP53INP1-DTP53INP1-ETP53INP1-FTP53INP1-GTSG101 -A WEE1 -A Relative...

... studyAthanasios N Georgiadis1, Eleni C Papavasiliou2, Evangelia S Lourida2, Yannis Alamanos3, Christina Kostara4, Alexandros D Tselepis2 and Alexandros A Drosos11Department of ... mortality among RA patients. Inactive RA, the majority of cardiovascular deaths result fromaccelerated atherosclerosis [2,8,9]. Risk factors for athero-sclerotic events and cardiovascular disease ... one year of therapy. The baseline values of CETP activity in ERApatients were significantly higher compared to controls,whereas they were significantly reduced after one year of ther-apy (Figure...

... subtyping, haemangiomas canbe divided into capillary, cavernous and venous types. A venous hemangioma is rare and is characteristicallypresent during adult life [13]. Pain is the cardinal symp-tom ... 60% of cases [14]. In our patient, a snap-ping hip was an extraordinarily rare presentation of a venous haemangioma. The crucial image modality is MRIwhile the choice of treatment is surgical ... consent was obtained from the patientfor publication of this case report and any accompanyingimages. A copy of the written consent is available forreview by the Editor-in-Chief of this journal.Competing...

... and plays a major detrimental role in delayedneuronal damage postischemia. The findings of Myers andYamaguchi [4] that glucose administration preischemia signif-icantly aggravates the postischemic ... Shock & CriticalCare, Bali, Indonesia, 24 August 2001.Abstract The glucose paradox of cerebral ischemia (namely, the aggravation of delayed ischemic neuronaldamage by preischemic hyperglycemia) ... have beenreproduced numerous times, and have repeatedly been pro-moted as the validation of the lactic acidosis hypothesis of cerebral ischemia. The glucose paradox as proof of the validity...

... degenerative disc disease Abstract The development of an e ective treatment for degenerative disc disease has been hampered for many years by what seems a fundamental problem; what exactly de ... original phenotype but perhaps retaining some of their original capacity. Have these cells altered their phenotype as a consequence of maturation or pathological events, or as an adaptive ... in the early days since we have yet to characterize the ubiquitous NP cell or to really understand the composition of the NP cellular milieu. e fl exible model of cell and tissue classifi cation...

... (Fig. 5). Analysis of ik3-1amino-acid sequence indicates that ik3-1 has a putative ZRXL(Z and X are typically basic) motif that would allow it to be a substrate by cyclin/cdk3 as well as cyclin/cdk2 ... correspond-ing to spot A and B arised by incomplete tryptic cleavage of the Ser274-containing region. In fact, phosphoamino-acidanalysis of spots A and B indicated that both spots A and Bcontained phosphoserine ... [15].RESULTSP70ik3-1 is phosphorylated by cyclin A/ cdk2, cyclin E/cdk2,cyclin A/ cdk3 or cyclin E/cdk3 which is produced in the baculoviral systemWe initially tested a hypothesis that p70ik3-1might be a regulatory...

... dr_ahmadkhaniha@yahoo.com2Tehran University of Medical Science, Tehran, IranFull list of author information is available at the end of the articleNaserbakht et al. Annals of General Psychiatry ... study providing data on a previouslyunexplored Iranian populatio n supports the hypothesisthat advanced paternal age and a birth rank of higherthan 3 (that is, higher age of father at birth) are ... 10:15http://www.annals-general-psychiatry.com/content/10/1/15Page 3 of 6PRIMARY RESEARCH Open AccessAdvanced paternal age is a risk factor forschizophrenia in IraniansMorteza Naserbakht1, Hamid-Reza Ahmadkhaniha2,3,4*,...

... musclenet2003@yahoo.com.tw1Department of Thoracic Surgery, Mackay Memorial Hospital, Taipei City,TaiwanFull list of author information is available at the end of the articleChen et al. Journal of Cardiothoracic Surgery 2011, ... Hospital, Taipei City,Taiwan.2Mackay Medicine, Nursing and Management College, Taipei City,Taiwan.3Graduate Institute of Mechanical and Electrical Engineering andGraduate Institute of Manufacturing ... defined asgrip strength lower than 25 kg in the dominant hand.Other laboratory data, history of other co-morbidities andrisk factors were also recorded for risk analysis. The stan-dard position...

... cytokines. The result is a production of pro-inflammatory cytokinesthat are b alanced by an array of anti-inflammatory cyto-kines. The coagulation pathway is also activated by LPS-mediated signaling ... os-ingDIC,wechosetomeasureD-Dimerasamarkerofcoagulation in this study as it is widely available, a cor-relate to the pro-inflammatory cytokine levels, and a valuable screening marker for organ failure and mortal-ity ... with equivalentnumber of patients for comparisons among lactate clear-ance quartiles.Statistical AnalysisFor the purpose of this study, lactat e clearance, biomar-kers and organ dysfunction...

... Intensive Care, Istanbul Medical Faculty, Capa Klinikleri, Istanbul,Turkey2Professor of Anesthesiology and Intensive Care, Department of Anesthesiology and Intensive Care, Istanbul Medical Faculty, ... oxygen delivery (DO2) and oxygen consump-tion were calculated at baseline and at all PEEP levels.R19Statistical analysisPaired analysis of variance tests were used to analyze the dif-ferences ... male and 6 female). The characteristics of the individualpatients are shown in Table 1. The mean age of the studypopulation was 47.2 ± 19.8, the mean Acute Physiology andChronic Health Evaluation...