Báo cáo sinh học: "Silencing the epidermal growth factor receptor gene with RNAi may be developed as a potential therapy for non small cell lung cancer" pot
... for citation purposes)
Genetic Vaccines and Therapy
Open Access
Research
Silencing the epidermal growth factor receptor gene with RNAi
may be developed as a potential therapy for non small cell ... stranded RNAsmall interference RNAnon small cell lung cancer
Abstract
Lung cancer has emerged as a leading cause of cancer death in the world...
... including the KEGG pathway database, PubMed
abstracts and the Entrez Gene database, including Gene-
RIF. ErbB and MAPK signaling pathway-related genes
T. Nagashima et al. EGFR mutation and MIG6 ... to the manufacturer’s instructions.
The probe was hybridized to the array for 16 h at 45 °C.
The hybridized probe array was then washed and stained
according to an automated proto...
... the manuscript. TH
participated in the design of the study and performed the statistical analysis.
EHH and AP participated in case selection and provided patient material for
analysis. DAW participated ... A significant association was
determined when the benign and the atypical samples were compared to the malignant with respect to the SP (p =
0.009). While there was...
... Munakata M , Nasuhara Y, Sato A, Takahashi T,
Homma Y, Kawakami Y: Expression of epidermal growth factor
and epidermal growth factor receptor immunoreactivity in the
asthmatic human airway. Am J Respir ... goblet -cell metaplasia without
changing the total number of epithelial cells, indicating
that the number of goblet cells increases and the number
of Clara cells dec...
... peptides
f2–f6 was carried out on the same Gilson chromatographic
apparatus using a PrePak Cart ridge 25 · 100 m m (Agilent)
casted on a PrepLC Un iversal Base apparatus (Waters) and
a Zorbax 300SB-C18 ... are in italics, the limit b etween the two EGF-repeats is shown by an a rrow. A
model of the tandem repeats is also shown on top as a Ca trace. After a search for...
... 5′-TCTTTCAATAAA-
CAGCGTGCTG-3′ )andEF2(5′-GCGGTCAGCACA
ATGGCATA and 5′ -GACATCACCAAGGGTGTG-
CAG-3′) were used. EF2 (elongation factor 2) was used
as a housekeeping gene. After incubation for 15 min at
95°C, ... Justyna Leja
1
, Anna Zagorska
1
, Aleksandra Sierpniowska
1
,
Jacek Stepniewski
1
, Magdalena Kozakowska
1
, Hevidar Taha
1
, Takahiro Ochiya
2
, Rafal Derlacz
3
, Elisa Vaha...
... controlled tri-
als comparing anti-biotic monotherapy (beta-lactams) for
febrile neutropenia. Cefepime was associated with higher
all-cause mortality at 30 days than other beta-lactams (RR
1.44, ... dead. The utility value
for the worst health state was determined against dead and
this was used to recalibrate the values for the other health
states on the dead (0) to full hea...
... WK,
Tran H, Tsao A, Xie D, Ramies DA, Mass R, Seshagiri S, Eberhard DA,
Kelley SK, Sandler A: Phase I/II trial evaluating the anti-vascular
endothelial growth factor monoclonal antibody bevacizu-
mab ... Biological agents in non- small cell lung can-
cer: a review of recent advances and clinical results with a
focus on epidermal growth factor receptor and vascular...
... negatively-
charged inner leaflet of the plasma membrane because
this agent is a weak base [93]. In any event, the action
of CaM on the downstream pathways of the EGFR,
such as the Ras ⁄ mitogen-activated ... intracellular Ca
2+
oscillations in microvascular
endothelial cells. J Cell Physiol 194, 139–150.
31 Tanaka Y, Hayashi N, Kaneko A, Ito T, Miyoshi E,
Sasaki Y, Fusamoto H...