Báo cáo y học: "Design principles of molecular networks revealed by global comparisons and composite motifs" pdf
Báo cáo y học: "Design principles of molecular networks revealed by global comparisons and composite motifs" pdf
... networks revealed by global comparisons and composite motifsHaiyuan Yu¤, Yu Xia¤, Valery Trifonov and Mark GersteinAddress: Department of Molecular Biophysics and Biochemistry, Whitney ... motif.Calculations of the random expectation of hub overlapsTo calculate random expectation of hub overlaps, we first cre-ated randomized networks for each biological network by randomly shuffling ... Materials and methods; Figure 1a).Importance of the four networks We chose these four networks because they are the most com-monly studied networks in yeast and because they can be eas-ily related...
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Báo cáo y học: "The genome of Apis mellifera: dialog between linkage mapping and sequence assembly" pdf
... sequence of the genome, but of the12,000 markers, only 2,605 were con-sidered as ‘unambiguously’ mapped and were used to assess the accuracy of theassembly [9]; most of the conflicts(1.8% of chromosomal ... the size of the assembled genome increased by 29 Mb (12% of the version 4.0 genome) as a result of additional sequencing reads and betterassembly, a total of 76 Mb of sequence (32% of the genome) ... misordering, eradicated by correction of genotyping errors detected by double crossovers.A few trivial differences persist betweenthe latest versions of the map and theassembly. Sixteen small scaffolds...
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Báo cáo y học: "Plastic architecture of bacterial genome revealed by comparative genomics of Photorhabdus variants" ppsx
... amplified by PCR with PstIdMutF and XbaIdMutR primers. The amplicon was hydrolyzed by PstI and XbaI, ligated into PstI- and XbaI-hydrolyzed pUC19, and inserted into E. coli XL1blue by transformation. ... purified by Nucleobond AX-100 kit(Macherey-Nagel, Hoerd, France), and the insert wassequenced with PstIdMutF and XbaIdMutR primers and then by chromosome walking.DNA microarray hybridization and ... fragments of between 1 and 10 kb if insert size was higher than 10 kb, and labeled with digoxygenin by random priming (Dig DNA labe-ling Kit; Roche, Meylan, France). Hybridization of the probeswas...
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Báo cáo y học: "Optimization principles of dendritic structure" docx
... feature of neurons. However, the principles determining their structure are poorly understood. By employing cable theory and, for the firsttime, graph theory, we describe dendritic anatomy solely ... Alexander Borst3,4 and Idan Segev5,6Address: 1Wolfson Institute for Biomedical Research, Department of Physiology, University College London, UK, 2Department of Physiology, University ... taperingdiameters and homogenous integration of spatially dis-tributed inputs are characteristic of many dendrites; these principles may well therefore be applicable for manyother systems. In recent years,...
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Báo cáo y học: "ntravenous transplantation of allogeneic bone marrow mesenchymal stem cells and its directional migration to the necrotic femoral head"
... Department of Orthopedics, Affiliated Hospital of Hebei University, Baoding 071000, China. 3. Laboratory of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Academy of Military ... arthroplasty [30,31]: Currently, the efficacy of arthroplasty has been significantly im-proved. However, nowadays, a lot of younger adults develop ischemic femoral head necrosis, and lifetime of ... animal im-aging system and adenovirus vector carrying GFP (Adeasy GFP) were used. The adenovirus vector car-rying GFP was kindly provided by Professor Zhou (Peking University, China). Experimental...
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Báo cáo y học: "Mechanical behaviour of standardized, endoskeleton-including hip spacers implanted into composite femurs"
... fixation where the distal and proximal parts of the spacer-stem are supported by using a composite femur. The suitability of the composite femur has been demonstrated by Cristofo-lini et al. [20] ... Jung W, Anagnostakos K. In vivo and in vitro studies of antibiotic release from and bacterial growth inhibition by antibiotic-impregnated polymethyl-methacrylate hip spacers. Antimicrob Agents ... porosity and wettability of gentamicin-loaded bone cements and their anti-biotic release. Biomaterials. 2000; 21(19):1981–1987. 26. Picknell B, Mizen L, Sutherland R. Antibacterial activity of...
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Báo cáo y học: "The Syndrome of Frontonasal Dysplasia, Callosal Agenesis, Basal Encephalocele, and Eye Anomalies – Phenotypic and Aetiologica"
... frontonasal dysplasia (MIM 136760 and 305645), acrofrontofacionasal dysostosis 1 (MIM 201180), acrofrontofacionasal dysostosis 2 (MIM 201181), frontofacionasal dysplasia (MIM 229400), oculoauriculofrontonasal ... Richieri-Costa A. New Syndrome of Growth and Mental Retardation, Structural Anomalies of the Central Nervous System and First Branchial Arch, Anophthalmia, Heminasal A/hypoplasia, and Atypical Clefting: ... different pattern of cerebral and facial manifestations ranging from normality to typical HPE phenotype. Penetrance is relatively low. Patient 1 of the present study was previously reported as...
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Báo cáo y học: "Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block"
... exercise LV dyssynchrony may play a more important role in the pathophysiology of left ven-tricular remodelling than baseline LV dyssynchrony (23). Probably for that reason additional hemodynamic ... biventricular pacing typically improves the time course of cardiac contraction at rest and during exer-cise by reducing LV dyssynchrony and thereby liber-ating a further segment of the RR interval ... evidence of myocarditis in endomyocardial biopsy, significant coronary artery stenoses revealed by angiography, valvular heart disease except of functional mitral re-gurgitation. Only patients...
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Báo cáo Y học: Identification of novel membrane proteins by searching for patterns in hydropathy profiles potx
... the acetylcholine (ACh) and glycine receptors of the cys-loop receptor superfamily.The key feature was a closely spaced triplet of hydropathypeaks bracketed by deep valleys. When applied to the ... (A) The hydropathy profile of a rat dopaminesymporter reveals a pair of peaks followed by a deep valley, then acluster of nine peaks. The peak, base and valley threshold levels used by the search ... number of profiles generated by the search algorithm.RESULTSA search strategy was designed for LGICs. The strategy wasrefined by applying it to custom polypeptide databases, and tested by applying...
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Báo cáo Y học: Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates docx
... Fractions with enzymatic activity wereanalysed by MALDI TOF MS and reversed-phase HPLCon a C4 cartridge. A molecular mass of 47 798 Da wasdetermined by MS and a single, symetrical peak was ... amidolytic activity was obtained by showing thatcommercial PAP hydrolysed the Abz-ISYQSSSTEEQ-EDDnp substrate at neutral pH, as does the puri®edenzyme. The ratio of the amidolytic activity of ... MicheÁle Ferrer1, Thierry Moreau1 and Francis Gauthier11Laboratory of Enzymology and Protein Chemistry, INSERM EMI-U 00-10, University FrancË ois Rabelais, Faculty of Medicine,Tours, France;2Departamento...
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