Báo cáo y học: "The Inferelator: an algorithm for learning parsimonious regulatory networks from systems-biology data sets de novo" pptx

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page)cspd1tfbfVNG0424CVNG0703H1911nirhANDnusa98ANDilluminationboa2gamma319AND388ANDcspd2371216VNG0194H254950557179tfbg1131232VNG0040Ctbpe19242967VNG0066H128VNG5075C263VNG0039HANDrhlVNG0320HtfbbVNG1029C59170283kaicANDtrh7156tbpd89219416423432449458gvpe228oxygen141148182188200338ANDtbpc2106phouprp1arsrsirr76124163174205226397VNG2476CVNG0293H9VNG1405Cimd111VNG0462CVNG6288C425768bat738486125139151162trh3208209223238244246257266273289298ANDZn322375Cu427AND458ANDrad3b184gvpe1VNG0156Cnusg253VNG5050H430ANDANDANDVNG2641H136275trh5215312AND10ANDANDVNG0826CVNG5130H264ANDVNG2163H175AND13VNG0511H19630914151718AND20212223ANDsnp27VNG0389C195269274imd2334357AND380ANDANDidr225826asncVNG1845C255VNG5009H296437ANDVNG0176HANDVNG5176Cboa32683031pai1boa4VNG2020CVNG2126C252260422AND32boa125126733AND343536373839AND40ANDVNG2614Htror25928241VNG0147C194224434445AND464748ANDANDAND5152AND5354565860AND61AND6263646566AND6970AND72FeAND7475ANDAND77AND78AND8081ANDAND82AND83VNG1483C19385AND878890AND9192939495AND969799AND100101102103104105106107108109AND110AND111112AND114AND115116117118trh4270AND119AND120121122ANDAND126127AND129130AND131132133134135AND137138140142143144145146147149150AND152153154155157158159AND160AND161AND164165ANDAND166167168169171172173AND176AND177178179180AND181183AND185186AND187189190AND192ANDANDANDANDAND198201202203204ANDAND206207ANDANDAND211212213214216217AND218220221222ANDAND225ANDAND227228231232AND233234235237AND239240241243ANDAND245247248249250254VNG0471C256AND265271272ANDAND276277278AND279280281284VNG0019HAND285286287VNG5144HAND288ANDAND290291292293295AND297299300301302303ANDAND304AND306307ANDNi308310ANDAND311313AND314315317AND318AND320ANDAND321324325ANDAND326329ANDAND330AND331332ANDAND335336AND337ANDAND339AND340AND341342ANDAND343AND344345AND346ANDAND347ANDAND348349ANDAND350351352AND353AND354355NAAND356ANDAND358359360361362ANDAND363AND364AND365AND366367AND368AND369372373374376AND377378ANDAND381AND382384385ANDAND386387389390391AND392393ANDAND394395AND396398399400AND401402AND403AND404AND405406ANDAND407408AND409410411412415AND417AND418AND420ANDAND421424425426ANDANDANDAND428AND429AND431ANDANDAND433AND434ANDAND435436AND438AND439AND440AND441442AND443444AND445ANDAND446AND447ANDAND448AND451AND452AND453AND454AND455AND456AND457ANDAND459ANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDANDAND(a)kaiCVNG2476CphoUVNG1405Cprp1sirR...

... thank Christopher Maher and Arul Chinnaiyan for providing us with their RNA-seq data. Thanks to Lou Staudt for invaluablefeedback on early versions of TopHat-Fusion, to Ryan Kelley for his indel-finding ... number of spanning reads and mate pairs reported by TopHat-Fusion and deFuse for ten previously reported fusion transcripts in the SKBR3and MCF7 sample data. Kim and Salzberg Genome Biology 2011, ... contributionsDK developed the TopHat-Fusion algorithms, performed the analysis anddiscussed the results, implemented TopHat-Fusion and wrote themanuscript. SLS developed the TopHat-Fusion algorithms, performed...

... held May 15th/16th, 2010, Toronto,Canada and was cosponsored by CHAEN/RCAH, the Canadian Society ofAllergy and Clinical Immunology, and the University of Calgary and wasfunded through an unrestricted ... receptor 2antagonist (Icatibant) for hereditary angioedema type III attacks. AnnAllergy Asthma Immunol 2009, 103:448.75. Frank MM, Gelfand JA, Atkinson JP: Hereditary angioedema: the clinicalsyndrome ... Consensus Algorithm For the Diagnosis, Therapy, andManagement of Hereditary Angioedema. J Allergy Clin Immunol2004;114:629-37, Copyright 2004, with permission from American Academyof Allergy, Asthma,...

... multisystem disorder,with acute renal failure, hypotension, sepsis, coagulopathy,encephalopathy and cerebral oedema [5,12]. Decisions aboutmanagement and prognosis must be made quickly in order ... specificity inidentifying patients with poor prognosis, but they are of lowsensitivity and may fail to identify a proportion of patients whowill die [13].In one study [16], the Acute Physiology and ... ventilation,particularly those who fulfil criteria for transplantation [12].Mannitol and thiopentone are used in management ofcerebral oedema, to maintain intracranial pressure below20 mmHg [12].Liver transplantation...

... hydrazone class aseffective antiproliferative agents II. The mechanism of action ofligands derived from salicylaldehyde benzoyl hydrazone and2-hydroxy-1-naphthylaldehyde benzoyl hydrazone. Blood 89,3025–3038.42. ... was obtained from Gibco BRL. DFO was obtained from Novartis Pharmaceutical Co. Pyridoxal isonicotinoylhydrazone (PIH) and its analogue, 2-hydroxy-1-naphthylal-dehyde isonicotinoyl hydrazone (311), ... native-PAGE-59Fe-autoradiographyNative-PAGE-59Fe-autoradiography was performed usingstandard techniques in our laboratory [38]. Bands on X-rayfilm were quantified by scanning densitometry using a LaserDensitometer and...

... mean and on the variance ofJ y (Nb)underbothassumptions.Thanks to the result of Corollary 1, we can deduce thefollowing result.Corollary 2. The asymptotical mean and variance ofJ y , ... N y u2=cum y u1+ N, y ∗u1, y ∗u2+ N y u2+ E y u1+ N y ∗u1E{ y ∗u2+ N )y u2+ E y u1+ N y u2E{ y ∗u2+ N y ∗u1+ E y u1+ ... a detection testAs only the asymptotic probability density function ofJ y (Nb)can be estimated when H0holds, we focus on the false alarmprobability. We therefore consider the constant...

... group.HAD-A, Hospital Anxiety and Depression Scale-Anxiety; HAD-D, Hospital Anxiety and Depression Scale-Depression.Annals of General Psychiatry 2009, 8:9 http://www.annals-general-psychiatry.com/content/8/1/9Page ... for suicide independent of DSM-III-R Axis I disorder. Case-con-trol psychological autopsy study in Northern Ireland. Br J Psy-chiatry 1999, 175:175-179.54. Nakane C: Japanese society Tokyo, ... personality disorder and from 0 to 9 for narcissistic personality disorder. A higher scoreindicates more severe pathology of each disorder.Depression and anxietyThe HADS [22], Japanese version...

... 38:170-187.4. Awata T, Kuzuya T, Matsuda A, Iwamoto Y, Kanazawa Y: Geneticanalysis of HLA class II alleles and susceptibility to type 1(insulin-dependent) diabetes mellitus in Japanese subjects.Diabetologia ... ethylenediamine tetraaceticacid-anticoagulated tubes and DNA was extracted usingstandard methods. A Taqman SNP genotyping assay wasdesigned for rs1990760 by Applied Biosystems (PE Biosys-tems, ... HTLV-1 andhuman herpes-6 or human herpes-8; however, evidence for arole of viruses in RA is circumstantial and inconclusive [21].Although no association between this genetic variant and RAwas detected,...

... statisticalanalysis.We consider model 6 of Verbeke and Molenberghs which is a typical randomcoefficient model for longitudinal data analysis with an intercept and a linearslope, and can be written as y ijk= ... Growth data from Pothoff and Roy [28] with the 9 missing values de nedby Little and Rubin [19]: see also Verbeke and Molenberghs [33] for a detailed analysis.Here 1st degree polynomial for the random ... response analysis, Foulley and Quaas [7] for heteroskedastic mixedmodels, and Meng and van Dyk [24] for mixed effects models using a Choleskydecomposition (see also procedures developed by Lindstrom...

... accomplished by RNA interferenceagainst Dfz2 in an fz mutant background, by analysis ofchromosomal deficiencies that delete Dfz2 (see Table 1), andby identifying mutations in Dfz2 and crossing ... Pathway specificity by thebifunctional receptor Frizzled is determined by affinity for Wingless. Molecular Cell 2000, 6:117-126. An important paper showing that ligand affinity plays a role in deter-mining ... polarity. Frizzled genes areessential for embryonic development, tissue and cell polarity, formation of neural synapses, andthe regulation of proliferation, and many other processes in developing...