Báo cáo y học: "Connecting the dots in Huntington’s disease with protein interaction networks" pptx

... and independentlyfusing these domains with candidate interacting proteins[21,22]. Constructs encoding these fusion proteins are trans-formed into yeast cells; if the two candidate proteins interact in ... independently fused with candidate interacting proteins (the bait andprey, respectively). If the bait and prey proteins interact (curved line) withina cell expressing both fusions, the resulting functional ... began by screening a fetal brain libraryusing the yeast two-hybrid method and identified new inter-acting proteins using a total of 52 baits. These baits includedproteins involved in cellular...

Báo cáo y học: " Novel genetic analysis in Behçet’s disease" ppsx

... this point by performing the initialanalysis on pooled samples and then, having identifiedpotential SNPs, validating the findings in each sampleEditorialNovel genetic analysis in Behçet’s disease Graham ... locuspreviously identified in a multiplex family study [2]. UBASH3Band UBAC2 encode ubiquitin-associated proteins. The ubiquitin system is best described in targeting misfolded ordamaged proteins for ... suchinvolvement. The authors correctly stated that the numbers with each manifestation make such an analysis very pre-liminary, but several other SNPs have been linked to ocular disease specifically, so these...

Báo cáo y học: "Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab" ppt

... determination ofsynovial autoantibody and immunoglobulin enrichment in biopsy materials obtained in clinical trials. ImmunoglobulinmRNA correlated with synovial protein levels, consistent with local ... trans-late into a significant effect on total IgG or total IgM protein. Finally, we determined the effect of rituximab on synovialautoantibody and immunoglobulin levels in the longitudinalARISE study ... immunoglobulin synthesis. Both anti-CCP and RF-IgMwere significantly enriched in synovial tissues containing lym-phoid aggregates. However, in an 8-week study, autoantibodyproduction in RA synovia...

Báo cáo y học: " Coronary arterial calcification in rheumatoid arthritis: comparison with the Multi-Ethnic Study of Atherosclerosis" pps

... specificity of individualinflammatory cytokines, these speculations are limited by the cross-sectional nature of the analysis, and the discrepancymay be the result of random variability. Importantly, ... anincreased burden of subclinical atherosclerosis, including CT-measured CAC [34]. A direct effect of inflammatory cytokineson the vasculature in promoting atherogenesis and destabiliz-ing ... focus onsubclinical disease, thus limiting potential skewing of CAC in groups with prior CV events and procedures. The mechanism underlying the observed increase in CAC in RA is likely complex and...

Báo cáo y học: " Filling the gaps in the genomic landscape" doc

... in- depth sampling of the Actinobacteria. By analyzing 56 of the newly sequenced genomes the authors demonstrate improvements in the rate of novel protein discovery and extend the diversity ... ﬁnding because it implied an in nite number of proteins present in the pan-genome of GBS. When the concept was extended to the Bacteria more widely by analyzing 573 bacterial species using ... novel protein families per genome. By sequencing bacterial genomes from under-represented phyla, they revealed that currently recognized protein diversity is likely to represent only a small...

Báo cáo y học: "Improving the delivery of care for patients with diabetes through understanding optimised team work and organisation in primary care" ppt

... of the respondents. In addition to the main study analysis, the patient surveywill be reported in its own right, including a comparison with the healthcare commission data (available from theirwebsite), ... measured, and their ability to predict quality of careover the subsequent 12 months is explored in the analysis.Participants and setting The study will be based in 100 general practices within the UK's ... organizations in primary and secondary care[31-33].Aim The aim of this study is to improve the quality of care forpatients with diabetes cared for in primary care by identi-fying individual,...

Báo cáo y học: "Unraveling the role of high mobility group box protein 1 in severe traum" doc

... characterizing the co-factors bound to HMGB1 in the setting of severe accidental injury would be extremelyuseful in delineating the mechanisms through which HMGB1may contribute to outcome in this clinical ... antibodies and other therapies capable ofenhancing the clearance of HMGB1 and its bound pro-inflammatory co-factors or of inhibiting interactions ofHMGB1 with macrophages and other cell populations ... thatare involved in acute inflammatory responses may have abeneficial effect on clinical outcome. Appropriately designedclinical trials will be necessary to answer this question.Competing interestsThe...

Báo cáo y học: "Tipping the balance in autoimmune disease" doc

... exhibitingclassical EAE with ascending paralysis, whereas the otherstrain had atypical EAE. The current emphasis of thesestudies is on understanding the pattern of trafficking ofthese T cells into the central ... fluorescently labeled VSV virus in mice resulted in capture of the virus by a distinct population of CD169+macrophages in the draining the lymph nodes. These cellsthen presented antigen to B cells within ... tip the balance.Another indication from these results is that immune stimuliare implicated in the initiation of autoimmune diseases,supporting the hypothesis that infectious diseases or otherinflammatory...

Báo cáo y học: " Introducing the Critical Care Forum’s ongoing review of medical statistics"

... but rather a starting point to inform readers and stimulatemore thought and investigation as to the most appropriate statistical methods to use and the theoryand assumptions behind them.Keywords ... Available online http://ccforum.com/content/6/1/003 The science of statistics is increasingly employed in all fieldsof medicine. Statistical techniques are used not only byacademics and clinicians ... complete course in medical statistics. There are many useful introductory textsEditorialIntroducing the Critical Care Forum’s ongoing review of medicalstatisticsElise Whitley* and Jonathan...

Báo cáo y học: "Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia" pptx

... A: Induction by inter-leukin-7 of lymphokine-activated killer activity in lymphocytesfrom autologous and syngeneic marrow transplant recipientsbefore and after systemic interleukin-2 therapy. ... could therefore result in aburst of thymic activity. In contrast, it is not immediatelyobvious what other factor(s) could determine the delayedrise in thymic activity in RA patients. Other ... circulating IL-6) and undetectable in synovial fluids [49]. In another study, IL-7 was elevated in RA synovial fluid but not in OA [50] and its production wasassociated with stromal cells in the synovium...

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