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Báo cáo y học: "Histones: should I stay or should I go" pdf

Báo cáo y học:

Báo cáo y học: "Histones: should I stay or should I go" pdf

... chromatin immunoprecipitation(ChIP) assays in combination with DNA microarrays thatcover the entire yeast genome at a 1 kilobase (kb) resolution,they found that immunoprecipitating Myc-tagged histoneH4 ... nucleosomes is dictated by the affin-ity of histone octamers for DNA, which is in turn highly regu-lated by the concerted action of ATP-dependent remodelingfactors and histone-modifying enzymes. In ... these reports may verywell reflect the diversity and subtlety of chromatin regula-tion at different genes, or we may simply be missing someimportant links in our understanding. It is clear,...
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Báo cáo y học: "A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy" pps

... variable clinical results were obtained with VC because of the difficulty of attaining clinically active doses.6 VK3 exhibited selective antitumor activity alone and in conjunction with many chemotherapeutic ... months and 11 continued for at least 1 year with one patient continuing for more than 2 years. Therapy was not discontinued in any patient due to vitamin toxicity or for other safety reasons. The ... Evaluations Each subject was interviewed by the study coordinator and examined by an urologist. Pretreatment evaluation included: a complete history and physical examination with a digital...
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Báo cáo y học: "Systemic lupus erythematosus and the type I interferon system" docx

... used both for therapy and to maintainremissions in SLE patients. This drug is known to inhibitIFN-α production by NIPCs/PDCs in vitro by the inhibitionof endosomal acidification/maturation [23]. ... prominent immunoregulatory effects andmight act as key cytokines, not only in the innate immunesystem but also in adaptive immune responses.Immunomodulatory effects by type I IFNsType I IFNs ... totally inhibited the IFN-α production. Thisindicates that unmethylated CpG-containing DNA mightbe involved in triggering the IFN-α production inNIPCs/PDCs. However, using oligodeoxyribonucleotide(ODN)...
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Báo cáo y học: " International Foot and Ankle Biomechanics Community (i-FAB): past, present and beyond" pdf

... for citation purposes)biomechanics community and welcomes input and direc-tion from members.In September 2008, we had our first congress at IstitutoOrtopedico Rizzoli, Bologna, Italy, chaired ... biomechanics ofposterior tibial tendon dysfunction and flatfoot deform-ity), Professor George Arangio (Sailing charted seas: bio-mechanics and the orthopaedic surgeon), Dr. MarioLafortune (The ... anklereplacement by Professor Sandro Giannini, hands-onmulti-segment foot kinematics demonstration by Profes-sor Maria Grazia Benedetti, and keynotes lectures by Pro-fessor Harold Kitaoka (Advances in biomechanics...
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Báo cáo y học: "Rare association between cystic fibrosis, Chiari I malformation, and hydrocephalus in a baby: a case report and review of the literature" potx

... patients with cystic fibrosis have unexplained neu-rological issues, Chiari I malformation is likely.Rakheja et al. described two babies with a knowndiagnosis of Chiari I malformation and hydrocephalus;however, ... gaitinstability; hand wastingChiari I with thoracic scoliosis andcervicothoracic syrinxChiaridecompressiontwomonthsResolution ofsymptomsPresentreport10monthsM Vomiting 2.2 cm of herniation; ... pressure or problematic Chiari malformation.DiscussionCF and Chiari I malformationCF is an autosomal recessive disorder characterized byabnormal chloride conduction across epithelial mem-branes....
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Báo cáo y học: "Pro/con clinical debate: Hydroxyethylstarches should be avoided in septic patient" pptx

... School of Medicine, Division of Pulmonary and Critical Care, Atlanta, Georgia, USA4Director, Pulmonary Clinic, Grady Memorial Hospital and Assistant Professor of Medicine, Emory University School ... of Medicine, Division of Pulmonaryand Critical Care, Atlanta, Georgia, USACorrespondence: Critical Care Editorial Office, editorial@ccforum.comPublished online: 19 February 2003 Critical Care ... on his intravascular volume. Fora variety of reasons you have decided you would like to givehim intravenous colloids. The only colloid available in yourintensive care unit is hydroxyethylstarch.CommentaryPro/con...
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Báo cáo y học: ""Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence" doc

... atrans-conformation, with the nitrogen-bond hydrogenand the carbonylic oxygen oriented in opposite direc-tions) (Figure 3D). SAHA, consistent with its non-specificinhibitory activity on HDACs ... Federico Mele, Rome, Italy, and Ms. Dora Pinto, ibidem, for technical help, Ms. Maria Grazia Bedetti, ibidem, for admin-istrative support, and Dr. Mark Kanieff, ibidem, for the linguistic revision. ... virus inte-grase inhibitors efficiently suppress feline immunodeficiencyvirus replication in vitro and provide a rationale to redesignantiretroviral treatment for feline AIDS. Retrovirology 2007,4:79.21....
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Báo cáo y học: "The value of monitoring outcomes should be measured by the appropriateness of the respons" ppt

... mortality outcomes graphically, and moreeasily and rapidly than is possible using the quarterlystandardized mortality ratios received from an ICU nationalaudit programme, as already exists in ... in England. The goal is tominimize delays in recognizing significant deterioration inperformance and to provide this expedited feedback locally to‘management and clinicians [who] are well placed ... analyses of large databaseswill improve patient care.The report by Cockings and coworkers in the previous issueof Critical Care [1] describes a method that allows individualICUs to monitor mortality...
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Báo cáo y học: "Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules" ppt

... pul-monary complications characterized by T-lymphocytealveolitis or lymphocytic interstitial pneumonia [7,8]. InTax-expressing transgenic mice, inflammatory cells con-sisting mainly of lymphocytes ... addition to the HAM/TSP[2,3] and T-lymphocyte alveolitis or lymphocytic intersti-tial pneumonia [7,8]. The pathological association ofHTLV -I with inflammatory multiorgan diseases in HTLV -I carriers ... Dr I. Futsuki for providing LTR-LUC. This work was sup-ported by Grants-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science; Scientific Research on Priority Areas...
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Báo cáo y học: "Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)" pps

... pro-virus is mainly detected in CD4-positive lymphocytes,with about 10% in CD8-positive T-lymphocytes [48]. Thissituation possibly arises because Tax mainly induces theincrease of CD4-positive ... T-lymphocytes in vivo byenhanced proliferation and suppressed apoptosis.In HTLV -I- infected individuals, no virions are detected inthe serum. In addition, the infectivity of free virions is ... also inhibitapoptosis by their pleiotropic actions. Since the HTLV -I provirus is randomly integrated into the host genome, theidentification of integration sites enables to identify eachinfected...
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