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Báo cáo y học: " Elucidating developmental gene networks" pot

Báo cáo y học:

Báo cáo y học: " Elucidating developmental gene networks" pot

... likely to function as regulatory elements, many ofthem organized in clusters in the vicinity of genes encodingknown developmental regulators. His group has developedfunctional in vivo assays ... Societies for Celland Developmental Biology, Warwick, UK, 31 March-3 April,2008.This year’s annual meeting of the British Societies for Celland Developmental Biology focused on several aspects ... aβ-globin minimal promoter; the embryos were then screenedat different developmental stages for GFP expression. Manyof the CNEs tested were able to spatially and temporally up-regulate GFP expression,...
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Báo cáo y học: "Construction of Gene Regulatory Networks using biclustering and Bayesian networks" docx

... modelling gene networks is that their topology should be sparse. This means that each gene is regulated by only a few other genes. In this work, a new gene regulatory network (GRN) construction system ... & Technology, Yemen. The authors would like to thank Prof Dana Pe'er, Columbia University; Dr Kevien Yip, Yale University and Prof G. Stolovitzky, IBM Computational Biology Center for ... molecular biology; Tokyo, Japan. 332355: ACM 2000: 127-135. 5. Wolfe C, Kohane I, Butte A: Systematic survey reveals general applicability of ``guilt-by-association'' within gene coexpression...
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Báo cáo y học: "Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers" pdf

... subtype 2AstrocytomaGlioblastomaCRCC 1Early stage HCCBreast carcinomaT−cell lymphomaOligodendrogliomaPapillary thyroid carcinoma 1 CTPapillary thyroid carcinoma 1 TCPapillary thyroid ... cancers is rudi-mentary. Our analysis suggests that tumors in group 1recapitulate an embryonic phenotype: they express early developmental and stem cell genes, suppress genes character-istic ... homology mappingOn Affymetrix arrays, a gene is often assayed by several probesets. We first reduced each platform to unique Entrez Gene IDs. To avoid artifacts in downstream analyses caused bybiased...
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Báo cáo Y học: In vitro gene therapy of mucopolysaccharidosis type I by lentiviral vectors pdf

Báo cáo Y học: In vitro gene therapy of mucopolysaccharidosis type I by lentiviral vectors pdf

... Biochemistry and Medical Biotechnologies, University of Naples Federico II; Italy2Laboratory for Gene Transferand Therapy, Institute for Cancer Research and Treatment, University of Turin, ItalyMucopolysaccharidosis ... expression of the IDUA gene to cellsin vivo for treatment of MPS I.Keywords: MPS I; Hurler syndrome; a-L-iduronidase; gene therapy.Mucopolysaccharidosis type I (MPS I) is a lysosomaldisease due ... hematopoietic stem cell gene therapy for mucopolysaccharidosis type I. Gene Ther. 7,1875–1883.17. Hartung, S.D., Reddy, R.G., Whitley, C.B. & McIvor, R.S. (1999)Enzymatic correction and...
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Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx

... autoantibody-producingB cells in the spleen of an SLE patient by analysis ofhybridomas generated from splenic B cells. The aims ofthe present study were to identify the immunoglobulinV genes used by ... min, followed by one cycleat 72°C for 15 min. The Taq polymerase used was of high-fidelity quality (Expand Easy; Roche, Mannheim, Germany),which has a very low error rate. Secondary amplificationused ... T15 heavychain gives rise to an antibody with autoantibody specificity.Proc Natl Acad Sci USA 1984, 81:5841-5844.5. Stott DI: Lessons about autoantibody specificity in systemiclupus erythematosus...
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Báo cáo y học: "Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population" docx

... present study shows that ER-α gene haplotype may be associated with primary knee OA, andgenetic variations in the ER-α gene may be involved in OA.Keywords: estrogen receptor, haplotype, knee ... threepolymorphisms in the ER-α gene (intron 1 T/C, intron 1 A/G andexon 8 G/A) and primary knee OA. Genotypes of the ER-α gene polymorphism were determined by PCR followed by restrictionenzyme digestion (PvuII ... receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean populationSheng-Yu Jin*1, Seung-Jae Hong*2, Hyung In Yang3, Sang-do Park3, Myung-Chul Yoo4, Hee...
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Báo cáo y học: "Novel IL10 gene family associations with systemic juvenile idiopathic arthritis" ppt

... Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE:Interleukin 10(IL-10) inhibits cytokine synthesis by humanmonocytes: an autoregulatory role of IL-10 produced bymonocytes. J Exp ... 2 (TH2) IL4 cytokine gene cluster, recent evi-dence from the mouse IL10 gene family cluster suggests thatthere is coordinate regulation of these cytokines by distal reg-ulatory elements spanning ... this disease.Two recently described members of the IL10 family are IL19and IL20. The genes encoding these cytokines are locatedwithin a highly conserved cytokine gene cluster in 1q32. Likethe...
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Báo cáo y học: "TXTGate: profiling gene groups with text-based information" ppsx

... glyceraldehyde-3-phosphate* glyceraldehyd_3_phosphat_dehydrogenasGPM1 TKL1 glyceraldehyde-3-phosphate dehydrogenase* glycolytPGK1 CDC19 phosphoglycerate kinase* glucosTDH3 HXK2 phosphoglycerate* enzymTDH2 TYE7 mutase* ... gene symbols that aremapped to different primary gene symbols; the second doesnot take synonyms into account, as only true occurrences of asymbol were counted. As a consequence, frequently ... informationGenome Biology 2004, 5:R43and one without alternative gene symbols; the former wasconstructed by mapping all synonymous symbols to the pri-mary gene symbol. The first table has...
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Báo cáo y học: "Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle" doc

... Gene Ontology) database [82] and to theKyoto Encyclopedia of Genes and Genomes (KEGG) path-ways database [83]. After the analyses were done with Gene- Codis, the redundancy on the list of genes ... used tosynthesize cRNA probes for hybridization to AffymetrixMGU74Av2 GeneChip high-density oligonucleotide microar-rays. Microarray hybridization was carried out as described inthe Gene Expression ... Wuerzburg: Physica-Verlag; 1985:131. 81. Genecodis 2.0, UCM access, Madrid [http://genecodis.dacya.ucm.es/]82. The Gene Ontology Database [http://www.geneontology.org/]83. KEGG Pathway Database...
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Báo cáo y học: "A fuzzy gene expression-based computational approach improves breast cancer prognostication" doc

... P(ER-/HER2-), P(HER2+) and P(ER+/HER2-) by P(1), P(2) and P(3), respectively.Fuzzy subtype cationcation of prognostic genessubtypesignaturesubtypesignaturesubtypesignatureModel buildingModel ... statistically com-pared the performance of the risk score and risk group pre-dictions through C-index by using a paired Student t-test[26,50]. Gene ontology and functional analysis Gene ontology analyses ... low-riskpatients, especially when there was discordance betweensubtypes identified by immunohistochemistry and by gene expression.Although the GENIUS methodology was used for prog-nostication...
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