Báo cáo y học: "Gene expression-based screening for inhibitors of PDGFR signaling" potx
Báo cáo y học: "Gene expression-based screening for inhibitors of PDGFR signaling" potx
... increasingly of interest to modulate the activity of particular signal transduc-tion pathways, but the components of such pathways are inmany cases only partially known. It would therefore be of interest ... proof -of- concept efforts toapproach the discovery of inhibitors of signal transductionusing a novel chemical genomic approach. We discovered apreviously unknown property of the triphenylmethane ... inhibitory potency of ATA. Thepositions and number of carboxyl and hydroxyl groups wereessential for PDGFR inhibition, as indicated by the fact thatno compounds in the second group inhibited PDGFR...
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Báo cáo y học: "Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells" potx
... FC, Verweij CL: Discovery of distinctive geneexpression profiles in rheumatoid synovium using cDNAmicroarray technology: evidence for the existence of multiplepathways of tissue destruction ... reasonably obtained.Surprisingly, information about the amount of bloodneeded to produce an analyzable sample has not beenuniformly reported; one group used lymphocytopheresis,suggesting a need for ... activity as measured by theSLEDAI, reinforcing the hypothesis that the IFN signatureis a measure of disease activity or severity [16].Inspection of gene expression data generated in our studyof...
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Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... geneticsynovectomy, and it is the latest development in thetradition of synovectomy, as performed surgically,chemically or by radiation therapy. In RA the fibroblast-liketype B synoviocyte is ... the synovium can transforminto an invasive tissue (pannus) that destroys cartilage andbone. Synovectomy of a joint, performed surgically,chemically or by radiation therapy, immediately stops ... these cyclin-dependent kinase inhibitors mayhave a much broader therapeutic spectrum.The therapeutic efficacy of genetic synovectomy can beimproved by cell-specific targeting of transformed synovio-cytes....
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Báo cáo y học: "Gene ontology analysis for RNA-seq: accounting for selection bias" pdf
... cate-gory testing on GO analysis. The techniques developedhere apply more generally, however, to any analysis thatlooks for over-representation of some category of interestamongst differentially ... analysis for microarray data, the null proba-bility distribution does not conform to a standard distri-bution, precluding an analytical solution for determiningthe probability of a category ... category have the same probability of being chosen, butthis probability is different from the probability of choos-ing genes outside this category. The mean of the probabil-ity weightings for...
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Báo cáo y học: "Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression" pptx
... calculated by analysis of variance of thelog-transformed, normalized expression. In the interests of speed, age and sex of animals were not included as cofactorsin the analysis of variance. ... implyanything about their suitability for other purposes. In addi-tion, modifications of any of those methods might make themmore suitable for QTL mapping.It is not clear why probes of a ... interval for the median.Number and types of QTLs in the three tissues defined by four methods of data summaryFigure 6Number and types of QTLs in the three tissues defined by four methods of data...
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Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
... overall efficiency of transgenesis (taking into account embryo loss in vitro and in vivo) is typically ca. 2% [9, 10, 11]. This level of efficiency is perfectly practicable for animal transgenesis, ... simply by the physical injection of a solution of cloned DNA into zygote pronulei [4]. Subsequently, Int. J. Med. Sci. 2004 1(2): 76-91 79 pronuclear microinjection is simply not known for ... manipulated to carry exogenous DNA. Retroviral vectors (RVVs) are one of the most frequently employed forms of gene delivery in somatic gene therapy [15, 16, 17]. Additionally, RVVs are able...
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Báo cáo y học: " laboratory driving simulation for assessment of driving behavior in adults with ADHD: a controlled study" docx
... Impact of remission definition and symptom type. Am J Psychiatry 2000,157:816-818.25. Biederman J, Petty C, Fried R, Fontanella J, Doyle AE, Seidman L,Faraone SV: Impact of Psychometrically-Defined ... diagnosis of adult ADHD, thesubject must have (1) met full DSM-IV criteria (at least 6 of 9 symptoms) for inattentive or hyperactive/impulsivesubtypes, with the onset of multiple symptoms by age 7years; ... start of any sudden move-ment of the steering wheel or depression of the brakepedal and rate of stopping before a traffic light or stop signwas also designed to be a proxy of hyperactivity.Statistical...
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Báo cáo y học: " Monocytes are essential for inhibition of synovial T-cell glucocorticoid-mediated apoptosis in rheumatoid arthritis" docx
... In vitro data wereanalyzed by one-way analysis of variance followed by Tukeypost hoc analysis or nonparametric Wilcoxon for paired sam-ples when appropriate. P values of less than 0.05 were ... hGR may vary considerablybetween different types of cells [20]. Thus, the local proinflam-matory milieu in an inflamed joint might contribute to the celltype-specific effect of locally administrated ... BergischGladbach, Germany) that resulted in a cell purity of more than90% as tested by flow cytometry with a phycoerythrin-conju-gated IgG1 mouse anti-human CD3 antibody (HIT3a; BD Bio-sciences)....
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Báo cáo y học: "Monocytes are essential for inhibition of synovial T-cell glucocorticoid-mediated apoptosis in rheumatoid arthritis" pdf
... Apoptosis and cell phenotype were evaluated byimmunohistochemistry and dual-immunofluorescence insynovial biopsy sections from 12 RA patients before and after amean of 11 days of an intra-articular ... In vitro data wereanalyzed by one-way analysis of variance followed by Tukeypost hoc analysis or nonparametric Wilcoxon for paired sam-ples when appropriate. P values of less than 0.05 were ... of hGR may vary considerablybetween different types of cells [20]. Thus, the local proinflam-matory milieu in an inflamed joint might contribute to the celltype-specific effect of locally...
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Báo cáo y học: "Rapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts" pps
... of PLGA, thus thefunction of the intracellular drug delivery system can bemodified. Therefore, this NPs-mediated drug deliverysystem works as an excellent ex vivo delivery of rapamy-cin for ... morphology were determined by dynamic light scatteringmethodology and electron microscopy. In vitro cytotoxicity of blank, rapamycin-loaded PLGA (RPLGA) NPs wasstudied using MTT Assay. Excised ... analysis of the in vitro drug release kinetics fromrapamycin loaded PLGA nanoparticles showed an earlyburst of drug release, approximately 27% of the totalamount of drug, was observed on day...
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Từ khóa: chuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát hiện xâm nhập dựa trên thuật toán k meansThơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ