... TFs, we examined whether they regulate the same genes as their duplicates. For the HGT
regulators, we examined whether they were co-transferred with nearby genes and whether they underwent repeated ... may
drive the evolution of gene clusters. Genetics 1996,
143:1843-1860.
36. Lawrence JG: Selfish operons: the evolutionary impact of gene
clustering in prokaryotes and...
... occlusion and left ventri-
cular aneurysm is more likely in FVL and PT G20210A
carriers. The findings of a recent study regarding the
increased frequencies of FVL or prothrombin variant
G20210A in patients ... However, none of the genotypes investigated were independently associated
with mortality.
Background
Clinical significance of gene polymorphisms involved in
ha...
... mucous
membranes, the gastrointestinal tract, and the throat,
the latter leading to potentially life-threat ening laryngeal
edema. Manifestation of acute edema in hereditary
angioedema is characterized by interindividual ... in hereditary angioedema (HAE) is characterized by interindividual and
intraindividual variability in symptom expression over time. Flexible therapy opt...
... contributions
CX and GYM were involved in patient management and
writing of the manuscript. CYH and ZYL were involved in
the writing of the manuscript. BZL and ZX were involved
in patient management. ... on any part of the body with
the trunk and extremities being the most common sites
of involvement where the incidence is 47% and
38% respectively [3]....
... flexibility so the therapy may be tuned to patient
body size and severity of illness. This process begins with
recognition of key features of the inflammatory response. The
network of IM, acting as ... 1466-609X)
Abstract
Circulating inflammatory mediators spilling into the circulation from sites of active inflammation are
considered the source of remote tissue injury...
...
rhabdomyolysis-induced kidney injury [26], in the outer
stripe of the outer medulla following ischemia and reper-
fusion [27,28], or in the inner stripe and inner medulla
following the induction of ... pathways,
associated with the regulation of the HIF signal, including
the control of HIF synthesis, HIF controlling PHD syn-
thesis, putative competing/inter...
... necessity - in the synthesis of the pepti-
doglycan of bacterial cell walls, for example. Our results show
the importance of including functional constraints to improve
models of the origin and evolution ... metabolite similarity
and binding versus catalytic enzyme properties, as well as
massive gene duplications and horizontal gene transfer, could
enhance our...
... rate
of change of VL and the presence of mutation.
Testing the hypothesis
The preliminary work relating to testing this hypothesis
requires longitudinal data that includes VL and sequence
data from ... recent analysis showed
that life expectancy at age 20 years had increased by over
13 years since the introduction of combination antiretro-
viral therapy and currently lif...
... purposes)
infliximab in ankylosing spondylitis [18] and inflammatory
bowel disease [19], but the determining factor in the concen-
tration-effect relation of infliximab is infliximab itself.
Only one ... months. Her infliximab dosage was increased
during the study, but she eventually discontinued the treat-
ment after V4.
Difference between preliminary and final therapeutic...