Báo cáo y học: "Identification of candidate predictive and surrogate molecular markers for dasatinib in prostate cancer: rationale for patient selection and efficacy monitoring" doc
... targets, including Abl, c-kit and
PDGFR kinases, showed minimal efficacy in early clinical
testing with a small number of patients [19,20]. Identification
of these preclinical candidate markers and ... R255
Research
Identification of candidate predictive and surrogate molecular
markers for dasatinib in prostate cancer: rationale for patient
selec...
... liverF
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... Culture and Stem cell culture
Primary mixed glial cultures were prepared from the
brains of newborn rats > 3 days old by dissociation of
whole cortex in trypsin, then cultured in poly-D-lysine
coated ... specificity,
cotranslational packaging and competition for limiting
Gag polyprotein [13]. These differences in the location of
the major packaging determinants may contri...
... prescription of
ChEIs has not yet been studied systematically. Therefore the main question of this
study is:
Do geriatric comorbidity and polypharmacy influence the prescription of ChEIs in
patients ... galantamine) in the incidence year.
Our main independent variables were polypharmacy and measures of geriatric
comorbidity. The concurrent use of multiple drugs is ofte...
... (IC50) of full-length DNA synthesis.
Determination of steady-state kinetic parameters
The Km for dATP and the Ki for TFV-DP were determined
by filter binding assays as described previously [36]. In
brief, ... resolved in 6% polyacrylamide-7M urea gel and ana-
lyzed by using the Molecular Dynamics Typhoon Phos-
phorimager system (GE Healthcare). To study the effect of
mutat...
... a candidate
citrullinated protein by immunoblotting lysates of monocytic and
granulocytic HL-60 cells treated with peptidylarginine
deiminase. In an initial screen of serum samples from four
patients ... that stained
positively for enolase, although the intensity of the staining
indicated that levels of citrullination were relatively low. Immu-
noblotting of synovial cell ly...
... Robert Haynes for the countless hours spent in caring for and
maintaining precise records of these RI lines and Sung Kim for his help
in analyzing the function and pathway associations of selected ... Paraffin-embedded sections
were de-paraffinized by immersing in xylene, followed by dehy-
drating in ethanol. The tissue sections were prepared and
stained with hemato...
... of up-
per/lower endoscopy in outpatients with iron defi-
ciency anemia. The aim of our study was to investi-
gate the incidence of GI pathological findings in
symptomatic and asymptomatic patients ... deficiency.
All patients were interrogated and examined
according to Form-1 in Figure 1. This form developed
by us for this study. The presence of dyspeptic com-
plaint...
... use of yeast two hybrid
system, which is a genetic assay for in vivo detection of
interactions of proteins, enables identification of protein-
protein interactions between a soluble bait and ... and its
interacting prey [5]. However, such a screening system is
not suitable for the analysis of interaction between
membrane bound proteins.
The split-ubiquitin yeast two...
... 2
Flow cytometric analysis of combinations of progenitor markers on freshly isolated and culture expanded chondrocytes from osteoarthritic cartilageFlow cytometric analysis of combinations of progenitor ... penicillin, 100 µg/ml streptomycin; Bio-
chrom, Berlin, Germany); fine mincing and digestion with
0.2% pronase (Roche, Mannheim, Germany) for 45 min at
37°C; and two furt...