Báo cáo y học: "Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools" ppsx
Báo cáo y học: "Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools" ppsx
... 10, Article R225ResearchPhylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment toolsWeichun Huang*†, ... exception of YY1E2F, a composite of YY1 and E2F and chosen on purpose for this study, the TFBS sites used herewere arbitrarily selected among those satisfying three crite-ria: binding site of a ... turnover simulations varying the binding site strength and GC content of the background sequences, and infor-mation on the E2F promoter data setAdditional results of turnover simulations varying...
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Báo cáo Y học: The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor pptx
... A.B. (1998) Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamicpeptide, hypocretin/orexin. J. Neurosci. 18, 7 962–7971.9. Date, Y. , Mondal, M.S., ... neuropeptides,NPY and orexins, are involved in the regulation of foodintake. Sensitivity of orexin A binding to NPY has beendescribed earlier by studying125I-labelled orexin A binding [30]. Interestingly ... trifluoroethanol-contain ing samples.Analysis of the spectra by a secondary structure estimation program (JASCO, J-700 for Windows) based on the method of Yang et al. [ 28] revealed a slightlyincreasing...
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Báo cáo y học: "Common interleukin-6 promoter variants associate with the more severe forms of distal interphalangeal osteoarthritis" pot
... testing.DiscussionThe present study showed an association between certain promoter genotypes of IL-6 and the more severe outcomes of DIP OA, namely symmetrical and symptomatic DIP OA. IL-6 isone of the ... thereports, a common guanine/cytosine polymorphism at position-174 in the promoter region of the IL-6 gene seems to have arole in a variety of diseases and conditions [14]. This variationregulates ... transcription of the IL-6 gene and is associatedwith plasma levels of IL-6 [15]. The activity of the promoter isalso affected by the nearby polymorphic sites at -597 and -572, which seem to control...
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Báo cáo y học: "Phylogenetic assessment of alignments reveals neglected tree signal in gaps" docx
... assessment of gap region accuracywere typically performed on simulated data only (forexample, [40]). Using simulation, Löytynoja and Gold-man, the authors of Prank, have recently argued thatother alignment ... (iii) What is the impact of align-ment uncertainty on tree inference?Phylogeny-based tests of alignment accuracyThe principle of the phylogeny-based tests of alignment accuracy is simple: the ... the common practice of trying morethan one alignment program on a given dataset. This lat-ter result, as well as the analysis on the impact of guidetree specification, rely exclusively on the...
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Báo cáo y học: "Phylogenetic detection of numerous gene duplications shared by animals, fungi and plants" ppsx
... M, Koonin EV: Analysis of rare genomicchanges does not support the unikont-bikont phylogeny and suggestscyanobacterial symbiosis as the point of primary radiation of eukaryotes.Genome Biol ... exceed-ingly unlikely that any synteny can still be detected.Another approach to the detection of large-scale dupli-cation is to analyze the rate of synonymous base sub-stitutions (dS) between ... probably represent only asmall fraction of the real number of duplications inearly eukaryotes, which could be i n the thousands. Ourresults could be most parsim oniously interpreted byone or...
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Báo cáo y học: " Phylogenetic history demonstrates two different lineages of dengue type 1 virus in Colombia" pot
... recovery and confirmationSeventy four viruses obtained from symptomaticpatients were isolated in mosquito cell culture and sub-sequently identified as DENV-1 serotype by monoclonalantibodies and ... Investigations. Transactions of the Royal Society of Tropical Medicine and Hygiene 1984, 78:239-241.9. Trent DW, Grant JA, Monath TP, Manske CL, Corina M, Fox GE: Geneticvariation and microevolution of ... washed with PBS and incubated again with afluorescent conjugated antibody. Additionally, DENV-1serotype confirmation was done by reverse transcriptionpolymerase chain r eaction (RT-PCR) using...
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Báo cáo y học: " Phylogenetic analyses of the polyprotein coding sequences of serotype O foot-and-mouth disease viruses in East Africa: evidence for interserotypic recombination" pps
... 2 Phylogenetic relationships of the VP1 coding region of type O East African viruses in comparison to other FMD virusserotypes. Evolutionary relationships of the VP1 coding region of FMD type ... coding region of serotype OFMD viruses from Kenya and Uganda has been undertaken to infer evolutionary relationships and processesresponsible for the generation and maintenance of diversity within ... Similarityplot with the Y- axis showing proportion of nucleotide identity and the X-axis showing the nucleotide positions along the alignment. Figure 7 Detec tion of recombinati on between serotypes...
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Báo cáo y học: " Phylogenetic analysis consistent with a clinical history of sexual transmission of HIV-1 from a single donor reveals transmission of highly distinct variants" docx
... first 249 days of infection. The plasma viral load for P1 was consistentlylower than P2 after day 96, with the exception of a sec-ondpeakreadinginP1takenonday249,afterthedetection of HIV-1 super-infection ... for random transmission of genetic variability [9].If transmission of viral variability is not random, thentransmission may occur by natural selection [17,18].However, transmissibility has ... donor maybe potentially transmissible at any one time, consistentwith the hypoth esis that transmission of viral variants isa random process.To demonstrate that this lack of predictability...
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Báo cáo y học: "Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition" docx
... Understanding and Control of Life's Function via Systems Biology), and in part by a grant from New Energy and Industrial Technology Devel-opment and Organization (NEDO) of the Ministry of Economy, ... upon exposure to medications and foods that cause hemolysis. Computer simulations foranalyzing this deficiency have been reported [17-19], butthese simulation models consisted only of glycolysis ... simulate any condi-tion. However, dynamic simulation based on kineticequations requires a large variety of rate equations and kinetic parameters, and unfortunately, such data are rarelyavailable...
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Báo cáo y học: " Computer simulation analysis of normal and abnormal development of the mammalian diaphragm" doc
... question of what type of data would be most useful and how simulation modeling can suggest avenues of experimental investigation. Embryogenesis is a period of profound growth. We believe that one of ... Children's Hospital of New York-Presbyterian and Department of Surgery, College of Physicians and Surgeons, Columbia University, 3959 Broadway, 216B, New York, NY 10032, USA and 2Olana Technologies, ... capable of 3D modeling, we favor first trying to construct a 2D model of any system. Two-dimensional simulations generally areeasier to construct from experimental data, are computa-tionally less...
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