Báo cáo y học: " Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and disease" ppsx
Báo cáo y học: " Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and disease" ppsx
... R213Research Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and diseaseGriet Vanpoucke¤*, Brigid Orr¤*, O Cathal Grace*, Ray Chan*, George R Ashley*, ... Smoothened and androgen receptor (AR),indicating an adequate sequencing depth to identify knownregulators of prostate organogenesis.VMP-VSU SAGE library comparison to identify inductive mesenchyme ... Neal D, Wasylyk B, et al.: Integrated DNA/RNA micro-array profiling of hormone-refractory clinical prostate can-cers and metastases indicates deregulation of severalpathways, including androgen/AR,...
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Báo cáo y học: "Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes" pdf
... (synaptosomal-associated protein, 25 kDa (SNAP25), cy-tokeratin (KRT) 8, KRT18, KRT19, N-cadherin (CDH2), sclerostin domain containing 1 (SOSTDC1) and integrin-binding sialoprotein (IBSP)), and ... cytoplasm of cells. KRT19 isalso a type I cytokeratin but unlike its related family mem-bers is not paired with a basic cytokeratin [40]. Members of the cytokeratin family are typically expressed by ... (synaptosomal-associated protein, 25 kDa (SNAP25), cy-tokeratin (KRT) 8, KRT18, KRT19, N-cadherin (CDH2) and integrin-bind-ing sialoprotein (IBSP)) and the notochord (NC) marker gene (T), and...
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Báo cáo y học: "Transcriptional profiling of the nucleus pulposus: say yes to notochord" pptx
... gene brachyury, which is required for diff erentiation and survival of the notochord [9]. Similarly to profi ling studies of rodents and canines, the study by Minogue and colleagues [1] indicated ... erapy, Minogue and colleagues [1] used transcriptional profi ling to examine the phenotypic characteristics of bovine intervertebral disc cells and provided some novel insights into the ... the cell loss and replacement by non-notochordal cells.© 2010 BioMed Central Ltd Transcriptional pro ling of the nucleus pulposus: say yes to notochordIrving M Shapiro* and Makarand V Risbud*See...
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Báo cáo y học: " Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes" pot
... body and is involved in sugartransport to peripheral tissues and energy storage [85]. Thisnon-reducing sugar is thought to increase desiccation toler-ance by preventing protein aggregation, and ... over-expression during development and adulthoodMnSOD males of the indicated lines were mated to rtTA(3)E2virgins and their progeny allowed to develop in bottles con-taining food plus and minus DOX. ... resulting in oxidative environments in the mitochondria and subsequently in the cytoplasm [103].It is also of interest to note that hydrogen peroxide and theantifungal para-hydroxymethyl-benzoic...
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Báo cáo y học: "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factor" ppt
... JA, Benbow U, Vincenti MP, Sporn MB, Brinck-erhoff CE: A synthetic triterpenoid selectively inhibits theinduction of matrix metalloproteinases 1 and 13 by inflamma-tory cytokines. Arthritis ... signal-regulated kinase;Ets = erythroblastosis twenty-six; GR = glucocorticoid receptor; IκB = inhibitor of κB; IKK = inhibitor of κB kinase; IL = interleukin; JNK = c-Jun N-terminal kinase; MAPK = mitogen-activated ... phosphorylates and activates NF-κB-inducing kinase (NIK). In turn, NIK activatesthe inhibitor of κB kinase (IKK) complex, which is responsible for phosphorylation of inhibitor of κB (IκB) and NF-κB1...
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Báo cáo y học: "Proteomic profiling of the mesenteric lymph after hemorrhagic shock: Differential gel electrophoresis and mass spectrometry analysis" pdf
... of PSML, possibly implicating proteins in the inflammatory processesleading to organ failure, and suggesting that characterizing the protein component of the lymph may provide key insights into ... spectrometry analysis. Here, wemeasured the proteomic profile of mesenteric lymph to identify underlying processes involved in the disease physiology of shock.ResultsDifferential comparison of pre and ... fundamentalmechanisms of MODS. Mass spectrometry based proteomic analysis of proteins in mesenteric lymph can effectively be used to identify candidate mediators and loss of protective agents in shock models.IntroductionMultiple...
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Báo cáo khoa học: Nuclear localization of human spermine oxidase isoforms – possible implications in drug response and disease etiology pptx
... cytoplasmic lysate were dansylated and analyzed byHPLC for localized quantitation of polyamine levels [42].Statistical significance of changes in individual polyaminepools was analyzed using ... reactive oxygen species(ROS), and has been linked to the cytotoxicityobserved in specific tumor cell types following treat-ment with antitumor, polyamine catabolism-inducingpolyamine analogues ... determination of dansylderivatives of unconjugated and acetylated polyaminesby reversed-phase liquid chromatography: improvedseparation systems for polyamines in cerebrospinalfluid, urine and tissue....
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Báo cáo y học: " Research ChIP-PaM: an algorithm to identify protein-DNA interaction using ChIP-Seq data" ppsx
... modeling and pattern matching of a specific tag count distribution of forward and reverse strands generated by protein-DNA binding, followed by de novo motif find-ing and searching within the ... asmuch as 90% of their time non-specifically bound to and diffusing along DNAs [15]. Likethe ability to bind to specific targets, non-specific binding to DNA is a bona fide TF abil-ity and therefore, ... potential binding regions. We show that our algorithm cangreatly reduce false positive findings while maintaining or improving accuracy and sta-tistical power for binding site discovery.Wu et...
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Báo cáo y học: "Respiratory pulse pressure variation fails to predict fluid responsiveness in acute respiratory distress syndrome" ppsx
... over threeconsecutive respiratory cycles, of the minimal value of systolic bloodpressure during a respiratory cycle and the value of systolic blood pressureduring apnea; HR: heart rate; LR+: ... driving pressure, airway plateau pressure minus total end-expiratory pressure; ΔPAOP:respiratory changes in pulmonary artery occlusion pressure; ΔPAP, respiratory changes in pulmonary artery pressure; ... pulmonary artery cathe-ter was ascertained by visualization of concordant wave-forms and calculation of the respiratory c hanges in PAOP (ΔPAOP) -to- respiratory changes in pulmonaryartery pressure...
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Báo cáo Y học: Transcriptional regulation of erythropoiesis Fine tuning of combinatorial multi-domain elements ppt
... played by specific domains in the corresponding transcription factors during in vivoerythroid and megakaryocyte development. Erythroid Kruppel-like factor (EKLF)This zinc finger protein plays ... (1999) Development of erythroid and myeloid progenitors in the yolk sacandembryoproperofthemouse .Development 126, 5073–5084.5. Orkin, S.H. (1996) Development of the hematopoietic system.Curr. Opin. ... that factor binding at HS3 initiates the process,allowing the spreading of open chromatin, binding of othertrans-acting factors throughout the LCR, and looping outintervening DNA to establish...
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