Báo cáo y học: "Making the most of high-throughput protein-interaction data" ppsx

... grouping of objects. They have two distinct types of nodes, and edges only connect a node of one type to a node of the other. For example, the proteins of a biological systemcould be the nodes of ... are the yeast two-hybrid (Y2 H) system [23] and affinity purification followedby mass spectrometry (AP-MS) [24]. The Y2 H system assayswhether proteins can physically interact with each other.Large-scale ... matrixtransposition. The one-mode graph of the proteins is the complex membership graph: two nodes are connected if theyare members of the same complex. Similarly, the one-mode graph of the complexes is the...

Báo cáo y học: "Making the most of high-throughput protein-interaction data" potx

... Boston, USA)presented the results of a thorough benchmarking of the yeast two-hybrid system. He convincingly showed thatinteractions discovered in high-throughput yeast two-hybridscreens were ... much about the abstract properties of biological networks, often with little application to day-to-daybiology, and the achievement of amazing milestones such as the first drafts of human interactomes ... report. These guidelines are supported by most of the maindata producers, which guarantees their wide acceptance, andwill hopefully result in publications of increased clarity and arapid, systematic...

Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"

... anticipated. These factors significantly reduced the power of the study. Based on their findings, the authors estimate that more than 100 hospitals would be needed to show the 30% difference they sought. ... goal of identifying and treating patients early in the course of their illness is preferable to waiting until more serious signs and symptoms have developed. Certainly, at the University of ... benefit for MET may take longer than the 6-month period of this study. Contamination of control hospitals also may have been an issue. Though they did not receive the study-based educational...

Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf

... although the HGGG loop was acritical structural element for the catalytic efﬁciency of the enzyme, the cold adaptation of the enzyme could not beattributed to the presence of the Gly cluster ... than the native cold adapted enzyme (Table 1). The mutantG261A /Y2 69A exhibits an Eaalmost the same as in the caseofthenativeenzyme(Table1).Thermal inactivation of mutant and wild-type enzymesIn ... replacement of Gly261 by Ala in mutantG261A resulted in an enzyme with slightly lower stability.On the other hand, in the double mutant G261A /Y2 69A the additional replacement of Tyr269 by Ala restores...

Tài liệu Báo cáo Y học: Dissecting the effect of triﬂuoroethanol on ribonuclease A Subtle structural changes detected by nonspeciﬁc proteases ppt

... the content of secondary structure only after the disruption of the native tertiary structure of RNase A(Figs 2–4). Interestingly, the preservation of the tertiarystructure coincides with the ... hydro-chloride (GdnHCl), urea or elevated temperatures, theydestroy the tertiary structure of proteins which results in the loss of enzymatic activity. Regarding the secondary struc-ture of ... signiﬁcantchanges of the spectroscopic properties of the enzyme couldbe detected. Therefore, the decrease of the proteolyticsusceptibility has to be attributed to a decreased (local)ﬂexibility of the RNase...

Báo cáo Y học: Probing the role of glutamic acid 139 of Anabaena ferredoxin-NADP+ reductase in the interaction with substrates pptx

... when studying the catalyticefficiency for these mutants in the diaphorase reaction, all of them yield values very close to those of the wild-typeenzyme at the different ionic strengths assayed (within ... FNR the side-chain of E139 might influence the properties of the flavin, assuming some of the functionscarried out by E301 in the wild-type enzyme [22]. In thiscontext, a special reactivity of the ... fitting of the kinetic traces shows only slightlyslower kobsvalues for the process ascribed to the formation of the initial charge-transfer complex with regard to that of the wild-type (Table...

Báo cáo Y học: Beyond the ABCs of CKC and SCC Do centromeres orchestrate sister chromatid cohesion or vice versa? potx

... complement of chromosomes. The ﬁdelity of chromosome transmission is enhanced notonly by the geometry of stable centromere–MT interac-tions, but also by the action of a centromere-basedregulatory system ... way, the critical connections that hold sisterstogether from S phase through early mitosis are literally cutby Ômolecular scissorsÕ in the form of Esp1/separase at the onset of anaphase. The ... redundancy between these two complexes, they arelikely to play distinct roles in meiosis. The most fascinatingproperty of Rec8 is its persistence at sister centromeres untilanaphase of meiosis...

Báo cáo y học: "Evaluating the Safety of Intranasal Steroids in the Treatment of Allergic Rhinitis" docx

... allergies are ‘ the most commonchronic condition in Canadians 12 years of age andolder.’’1In one study, 42% of children were diagnosedwith AR by the age of 6 years. The prevalence of AR hasincreased ... for the clinician to be comfortable with the side-effect profile and be able to discuss potential safety concerns regarding these therapies.Among the safety concerns with the use of INCs are the ... for the clinician to be comfortablewith the- side effect profile and be able to discuss potentialsafety concerns regarding these therapies. Among the safety concerns with the use of INCs are the...

Báo cáo y học: "Dissecting the determinants of depressive disorders outcome: an in depth analysis of two clinical cases" pot

... 1Institute of Psychiatry, University of Bologna, Italy, 2Department of Psychology, Catholic University, Milan, Italy and 3Department of Psychiatry, San Raffaele Scientific Institute, Milan, ItalyEmail: ... bipolardisorder of Mr. A daughter strengthen the genetic hypoth-esis. On the contrary, only Mrs. B mother aunt wasaffected by depression and anxiety, pharmacologicallytreated. Therefore, the genetic ... higher eveningnessin subjects carrying at least one copy of the C allele [80].In another study the possible role of the same polymor-phism in the regulation of diurnal mood fluctuations dur-ing...

Báo cáo y học: "Comparing the prevalence of rheumatic diseases in China with the rest of the world" pptx

... forankylosing spondylitis and rheumatoid arthritis, an absence of fibromyalgia, and a temporal increase in the prevalence of gout. What should we make of all of these estimates and whyare they important ... regardingrheumatic disease etiology.Zeng and colleagues reviewed diverse studies, many of themusing the Community Oriented Program for the Control of Rheumatic Diseases (COPCORD) protocol. The COPCORDhas been ... for rheumatoidarthritis, many of these studies only detected a few cases in acommunity, so the estimate of prevalence is accompanied bywide confidence bounds, and there was substantial variationin...

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