Báo cáo y học: "Reduced selection leads to accelerated gene loss in Shigella" potx

... in purifying selection may lead to other gene loss events that may be adaptive. For example, loss of flagellargenes may occur in Shigella due to a pathway-specific reduc-tion in purifying selection, ... finding that thegenes that are lost more readily are those that are less con-strained in the organisms in which they are maintained pointstowards reduced purifying selection playing a prominent ... changes in the efficacy of purifying selection, changes in the patterns of positive selection may also play arole in determining gene loss. Specifically, the products ofsome genes may be detrimental...

Báo cáo y học: "Hedgehog overexpression leads to the formation of prostate cancer stem cells with metastatic property irrespective of androgen receptor expression in the mouse model" pps

... detected in the cytoplasmof cells in the HGPIN (high grade PIN) lesions (Figure 3A;arrow-indicated in (c)) and CaP (Figure 3A; arrow-indicated in (d)). Interestingly, P63 was expressed in some ... evidence sofar to support this hypothesis.Hedgehog (Hh) signalling plays a key role in stem cellplasticity and in many developmental, physiological, andpathogenetic processes [15]. Binding of the ... (Figure 2H to 2J and 2M to 2O).Moreover, Hh signal ing proteins were expressed hetero-geneously, i.e. only in some cell lineages of the PINlesions (Figure 2F to 2J; indicated by arrowheads)...

Báo cáo y học: "Chronic arthritis leads to disturbances in the bone collagen network" pps

... strongly affected by theinflammatory process and ultimately this interferes withbone mechanical performance. In addition, scanningelectron microscopy findings showed that SKG miceexhibit thinner ... the loss of boneorganic matrix. It was therefore of interest to use thenewly discovered potential of multiphoton microscopy to analyze this issue in more detail. Multiphoton micros-copy in ... Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan, 8University of Helsinki, Department of Medicine; ORTON Orthopaedic Hospital of the Invalid Foundation,...

Báo cáo y học: "Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics" pdf

... BMP-7 to healthy FLSs in vitro had no effect on α-smaFigure 1Haematoxylin and eosin staining on healthy and arthritic synovial tissueHaematoxylin and eosin staining on healthy and arthritic synovial ... previously described, staining of human synovial tissue withhaematoxylin and eosin showed an increase in the number ofcell layers of the synovial lining of RA patients (Figure 1). E-cadherin staining ... The finding that E-cadherin andcollagen type IV are expressed in the lining layer of healthy andarthritic synovium indicates that these lining cells display anepithelial-like phenotype. In addition,...

Báo cáo y học: "Acute myopathy secondary to oral steroid therapy in a 49-year-old man: a case report" docx

... myopathy occurringafter two doses of methylprednisolone. Typically, acute steroid myopathy occurs with therapy using intravenouscorticosteroids at high doses. Acute myopathy developing very ... on day 2 of therapy.Initially, he ignored the symptoms, but his conditioncontinued to escalate in a generalized fashion. On day 3of the rapy, myalgia and muscle weakness progressed to involve ... did find increased urinary creati-nineexcretiontobemoreconsistentlyabnormalthanelevated CPK [10].EMG may be normal, but abnormal EMG findingsclassically include normal sensory and motor conductionvelocities...

Báo cáo y học: "Functional impairment related to painful physical symptoms in patients with generalized anxiety disorder with or without comorbid major depressive disorder: post hoc analysis of a crosssectional study" docx

... be desirable to pay special attention not only to the typical symptoms of the disease but also to thesePPS. Therefore, clinicians may routinely evaluate theextent to which symptoms impact patients’ ... DN:Efficacy of duloxetine in the treatment of generalized anxiety disorder in patients with clinically significant pain symptoms. Depress Anxiety 2008,25:E1-11.31. Demyttenaere K, Bonnewyn A, Bruffaerts ... was carried out in a primary care setting cover-ing 87 sites in Spain during April-June, 2007. The studyhad 3 stages in its design, including a consecutive screen-ing to identify high-ris k patients...

Báo cáo y học: " Perception of urge-to-cough and dyspnea in healthy smokers with decreased cough reflex sensitivity" potx

... airways [12]. Somepulmonary and airway sensory receptors and afferentpathways may be co mmon to both the urge -to- coughand dyspnea [11]. In addition, brain imaging studiesshowed the brain cortical ... respiratory defense mechanism, bluntedcough reflex sensitivity may contribute to the risk ofrespiratory tract infection in cigarette smokers. More-over, since dyspnea is usually a symptom at ... cough reflex sen-sitivity in healthy smoke rs might be explained solely bythe supramedually mechanism.Cigarettesmokingappearstobeamajorriskfactorfor respiratory tract infe ctions [4]. As cough...

Báo cáo y học: "Bedside diagnostic laparoscopy to diagnose intraabdominal pathology in the intensive care unit" pot

... pathology in the intensive care unit (ICU) increases rates of morbidity andmortality. Intraabdominal pathologies are usually identifiedthrough presenting symptoms, clinical signs, and laboratory ... delay diagnosisbecause of inconclusive laboratory tests or imaging results, orthe inability to safely transfer a patient to the radiology room. In the current study we evaluated the safety and ... pro-posed in post-traumatic intraabdominal injuries, to facilitate afaster diagnosis in the emergency room. Its use in this settinghas been extensively analysed by Stefanidis and colleagues in a...

Báo cáo y học: "A novel scheme to assess factors involved in the reproducibility of DNA-microarray data" pdf

... only slide 1 contains a self-hybridization. The VSG interaction contains variances due to hybridization and sampling. Some factors are confounded Due to the fact that in our DNA-microarray ... handle a gene factor of 2108 levels (genes) and additional interactions in model (1). To reduce data dimensions, we chose to randomly select genes instead of other methods (e.g. grouping of genes ... bleaching. The main contributing factors identified in this study are in agreement with a number of studies involving cDNA derived from eukaryotic tissue cultures [18,19,24]. In contrast to these...

Báo cáo y học: "A novel approach to identifying regulatory motifs in distantly related genomes" pps

... successful in the identification of regulatory motifs, phylogenetic footprintingmethods still show some shortcomings. To assess these difficulties, most apparent when applyingphylogenetic footprinting ... to anyset of organisms and genes for which one wants to comparethe intergenic sequences.ResultsA two-step procedure for phylogenetic footprinting In this study, we aimed to detect regulatory ... Discovery of regulatory elements by acomputational method for phylogenetic footprinting.Genome Res 2002, 12:739-748.27. Blanchette M, Tompa M: FootPrinter: A program designed forphylogenetic...

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