Báo cáo y học: "Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity" potx
Báo cáo y học: "Toxicogenomic analysis of Caenorhabditis elegans reveals novel genes and pathways involved in the resistance to cadmium toxicity" potx
... 5).Protein interaction analysis reveals a novel pathway involved in the response to cadmium In order to further define the molecular mechanisms of the cadmium defense response, the program Cytoscape ... when the expression of only one of the redundant genes is affected.By integrating the RNAi assay results into the protein interac-tion network, a novel signal pathway involved in cadmium resistance ... functions may be disrupted by cad-mium toxicity.Discovery of novel genes and pathways involved in cadmium resistance In C. elegans, mtl-1, mtl-2, cdr-1 and ttm-1 (Toxin-regulatedtarget of p38...
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Báo cáo y học: "Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells" ppt
... upon activation of the insulin and wingless pathways in S2 cellsBinding of insulin-like peptides to the insulin receptor in Drosophila cells leads to the activation of dPI3 kinase, whichhttp://genomebiology.com/2009/10/1/R11 ... crosstalk with other signaling pathways. For example, patterning of the wing imaginal disc is achievedmainly through the interplay of the transforming growth fac-tor (TGF), Wingless, Notch and Hedgehog ... induction of the insulin (top) and wingless (bottom) sig-naling pathways. It also includes the sequence of the probes.Additional data file 3 is a table listing the results from the GOanalyses...
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Báo cáo y học: " Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression"
... thymocytes when compared to the young by real-time RT-PCR (Figure 5). These genes thus may be a contrib-uting factor to the increase in B cells, both in total number and in maturity, within the ... group of genes warranting further scrutiny. In order to obtain an expression profile of the genes which changed the most with age, we uploaded all of our array data into the array analysis ... this group of pathways may be vital to thymocyte survival or death during thymic involution. Both the PI3/Akt and ubiquinone synthesis pathways contained a relatively large number of genes which...
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Báo cáo y học: "Detailed analysis of 15q11-q14 sequence corrects errors and gaps in the public access sequence to fully reveal large segmental duplications at breakpoints for Prader-Willi, Angelman, and inv dup(15) syndromes" pdf
... is indicated by the four rows of segments at the top. The first row, continuing to the third row, represents the upper RP11 haplotigs in Figure 5 and the second row, continuing to the fourth row, ... results close gap 3 and clearly show that the beginning of NT_078094 is directlyconnected to the beginning of NT_026446 (Figure 4c). One of these contigs is therefore in the wrong orientation, ... frequent in a regionextending from the centromere to the beginning of segment J. In a similar study conducted in the same sample, Sharp and coworkers [34] also found a very high frequency of CNVs in this...
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Báo cáo y học: "Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu''''s unique role in shaping the human transcriptom" pptx
... potentially contribute to proteome diversity? The majority of exonizations in our dataset inserted an in- frame stop codon within the CDS (in 61% to 84% of the cases); in 9% to 24% of the cases they ... new introns [20]. In only two cases is the origin of the intron known: a SINE insertion that gave rise to a new intron in the coding region of the catalase A gene of rice, and two midge globin genes ... cases in which the exonizationswere constitutive and not symmetric, they were introducedwithin hypothetical proteins. In these cases, these are eithernot bona fide protein coding genes, or they...
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Báo cáo y học: " GeneChip analysis of human embryonic stem cell differentiation into hemangioblasts: an in silico dissection of mixed phenotypes" docx
... T-brachyury, MESP1). Further examination of the data set identified multiple genes involved in the BMPsignaling pathway in the differentiation of blood and endothelial cells. These genes include ... 1). To summarize,comparing BCs to leukocytes identified genes involved in vas-culogenesis, to endothelial cells identified genes involved in hematopoiesis, and to stromal cells identified genes ... EBs,orange; and BCs, red. GenMapp analysis of pathways involved in whole blood, bone marrow, coagulation and com-plement, heme and porphyrin synthesis are indicative of hematopoietic cell types (Figure...
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Báo cáo y học: "A compendium of Caenorhabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory network" ppsx
... types of components, or nodes: the genes involved in the system and the TFs that regulate their expression. Protein-protein interactions between TFs and protein-DNA interactions between TFs and their ... in DNA-binding, includ-ing SAND [28], and THAP zinc-finger [29] domains. For sev-eral of the domains unique to wTF2.0 (CP2, WH-DAC, IPT/TIG, TEA/ATTS, WT1, YL1), the genes encoding them werenot ... between 2 and 10. Interestingly, 30 TFvariants, corresponding to 25 TF genes, no longer contain aDNA binding domain. Rather than binding DNA and regulat-ing target gene expression directly, these...
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Báo cáo y học: " Diagnostic value of anti-human citrullinated fibrinogen ELISA and comparison with four other anti-citrullinated protein assays" potx
... presence of citrullinated fibrin in the synovial membrane of RA patients [17] and the use of cit-rullinated fibrinogen to assay the serum antibodies to deimi-nated fibrinogen (anti-human citrullinated ... cyclic citrullinated peptide.Figure 3Dendrogram of the cluster analysis of the different ACPA assays in population 2Dendrogram of the cluster analysis of the different ACPA assays in population ... using ELISA, and anti-PepA and anti-PepB antibodies using line immunoassay.Applying previously proposed cut-offs for AhFibA, we obtaineda sensitivity of 60.9% and a specificity of 98.7% in...
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Báo cáo y học: "Partial pressure of end-tidal carbon dioxide successful predicts cardiopulmonary resuscitation in the field: a prospective observational study" potx
... participated in designing the study, collection and analysis of data, and helped to draft the manuscript. MK participated in designing the study, and collection and statistical analysis of data. ... arrest was induced by asphyxia. In thisstudy the PetCO2 values during CPR were initially high, thendecreasing to subnormal levels and then increasing again to near-normal levels in patients ... in designing the study and helped to draft the manuscript. ŠG participated in designing the study,collection and analysis of data, revised the manuscript forimportant intellectual content and...
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Báo cáo y học: "Partial pressure of end-tidal carbon dioxide predicts successful cardiopulmonary resuscitation in the field" docx
... promptly signals the return of spontaneouscirculation [2]. PetCO2 is likely to promptly identify asphyxia, in contrast to primary cardiac causes of arrest as previouslyreported by one of the ... doubling of the responsetime of professional rescuers, presumably in the absence of bystander utilization of automated external defibrillators,especially since a majority of survivors had shockableventricular ... disproportionate airway injury. The alternatives of a laryngeal mask airway or even a facial mask incorporatinga mainstream carbon dioxide sensor may be utilized. Becauseinjection of bolus epinephrine produces...
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