... and drafted the manuscript. TH, RG, HK, GRB, and AS partici-pated in the coordination of the study and in drafting the man-uscript. TD participated in the design and coordination of the study, and ... 50:1117-1121.11. Barton A, Bowes J, Eyre S, Symmons D, Worthington J, Silman A:Investigation of polymorphisms in the PADI4 gene in deter-mining severity of inflammatory polyarthritis. Ann Rheum ... deimination of protein-boundarginine to citrulline [1]. Five different types of peptidylargininedeiminases encoded by the genes PADI1–PADI4 and PADI6are currently known [1]. The presence of...