... typical findings of lung injury, such as intra-alveolar exudates, hyaline membrane formation, inflammatory cell infiltration, intra-alveolar hemorrhage, and interstitial edema. These findings ... has beendetermined by preliminary studies using various MV settings.Histopathologic examination of the lung tissues every 30 min-utes allowed determination of the time and setting that yieldedtypical ... activity and inflammatory cytokine concentra-tions, which were correlated with PARP activity. These resultssuggest the transcriptional modulation of PARP in inflamma-tory lung injury during VILI....