... of α-subunits, and two transactivating domains, namely theamino-terminal transactivating domain and the carboxyl-terminal transactivating domain (C-TAD). The C-TAD hasbeen shown to interact with co-activators ... expression of which isdramatically upregulated by hypoxia in many cells types, includingRA synovial membrane cells. This leads to an apparent paradox,with the abundant synovial vasculature (which ... Ley SC, PughCW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ: Post-translational hydroxylation of ankyrin repeats in IkappaB pro-teins by the hypoxia-inducible factor (HIF) asparaginylhydroxylase,...