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Báo cáo y học: "The role of emergency medicine physicians in trauma care in North America: evolution of a specialty" pps

Báo cáo y học:

Báo cáo y học: "The role of emergency medicine physicians in trauma care in North America: evolution of a specialty" pps

... trauma care thanthose whose training allows exposure to trauma only aspart of their general EM training, particularly if a separate trauma team responds for trauma activations. In smaller North ... for citation purposes)Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine Open AccessReviewThe role of emergency medicine physicians in trauma care in North America: evolution ... the patient to a trauma center. EMP's therefore may play a significant role in theinitial phase of trauma care as part of their overall workflow in many US hospitals that are not trauma centers.The...
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Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf

Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf

... GACTTGReverse TCCGGGACCACTTTTGAATACTTTCAAGTGCATATATTTATTP74G Forward CAAAAGTCTTGGCGGACAAAATGAGGACTTGGTACReverse CATTTTGTCCGCCAAGACTTTTGAATACTT TCAAGTGCQ76G Forward CTTCCCGGAGGAAATGAGGACTTGGTACTTACTGReverse ... loop of cystatin A fulfils thesame function as the second binding loops of cystatin B andfamily 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction.To ... representing thethird family, are glycosylated proteins of about 50–90 kDa.The single polypeptide chain of a kininogen contains threedomains resembling family 2 cystatins.Cystatins competitively inhibit...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf

Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf

... ThebF24rv mutagenic primer was 5¢-ATAAGTATACGCAGGCGCATACCAGCCAAACTGCGGGCCATTTAC-3¢and the bF57rv mutagenic primer was 5¢-GGAAATCACACCATTATGACCAAAAACCAGCCCGGGATAGGC-3¢. The underlined codons ... acylation by PGA in a similar way as theacylation by NIPAB. A notable exception was the twofoldincreased activity for PGA of the aF14 6Y mutant. Itappeared that this mutant had a kcatvalue ... using the methyl ester or the amide asacyl donor.It appeared that 6-APA and 7-ADCA were able toefficiently deacylate the phenylglycyl- and p-hydroxyphe-nylglycyl-enzyme of bF2 4A, as indicated...
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Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc

Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc

... (antisense); in the second mutant, Cys239was exchanged for Ala using the primers 5ÂCGTGACTGTACTCCACATCgcTGGTAAGGTTAACGC (sense) and5ÂGCGTTAACCTTACCAgcGATGTGGAGTACAGTCACG (antisense). The mutated bases ... Ferguson, D.J., Krzycki, J .A. & Grahame, D .A. (1996) Specificroles of methylcobamide:coenzyme M methyltransferase isozymes in metabolism of methanol and methylamines in Methanosarcinabarkeri. J. ... are proposed to be involved in ligating zinc, resulted in an over 90% loss in enzyme activityand in distinct changes in the zinc ligands. In theHis237 fi Ala and Cys239 fi Ala mutants, coenzyme...
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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

... Taiwan;3Department of Pharmacy and Pharmacology, The University of Bath, UKDeacetoxycephalosporin C synthase (DAOCS) catalyses theoxidative ring expansion of penicillin N, the committed step in the ... deacetoxycephalosporin C (DAOC 2 )in Streptomyces clavuligerus [1–7]. The subsequent hydroxyla-tion of DAOC to give deacetylcephalosporin C (DAC 3)iscatalysed by a closely related oxygenase, deacetylcephalo-sporin ... Fax: + 44 1225 386114, E-mail: M.D.Lloyd@bath.ac.ukAbbreviations: DAC, deacetylcephalosporin C; DACS, deacetylcephalosporin C synthase; DAOC, deacetoxycephalosporin C; DAOCS,deacetoxycephalosporin...
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Báo cáo y học: "The role of Probiotics in allergic diseases" pptx

... improvement of scores, the use of heat-inactivated Lactobacillus GG was associated withadverse gastrointestinal symptoms and further studyenrollment was thus halted.Another study by Kirjavainen et al ... composition of gut microbiota of allergic infants. a target of bifidobacterial therapy at wean-ing? Gut 2002, 51(1):51-5.8. Kirjavainen PV, et al.: Characterizing the composition of intes-tinal microflora ... withoutLactobacillus acidophilus to adolescents and adults withasthma who were sensitized to inhalant allergens. Therewas no difference in clinical parameters of asthma or lab-oratory markers of inflammation[53]....
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Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc

... func-tional activity of a glucocorticoid-regulated inflammatorycyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892.7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam-matory ... post-operative pain in patients requiring bone healing, I wouldadvise that physicians and their patients be familiar withthe information and make decisions accordingly. I wouldadvise that if ... animal data to our management of patients. However,before doing this, certain points must be considered.Most of the studies in animals have evaluated healing atfairly early time points. Because...
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Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt

... of α-subunits, and two transactivating domains, namely theamino-terminal transactivating domain and the carboxyl-terminal transactivating domain (C-TAD). The C-TAD hasbeen shown to interact with co-activators ... expression of which isdramatically upregulated by hypoxia in many cells types, includingRA synovial membrane cells. This leads to an apparent paradox,with the abundant synovial vasculature (which ... Ley SC, PughCW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ: Post-translational hydroxylation of ankyrin repeats in IkappaB pro-teins by the hypoxia-inducible factor (HIF) asparaginylhydroxylase,...
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Báo cáo y học: "The role of osteoprotegerin in arthritis" ppsx

... Weichselbaum in the Archives forPathology, Anatomy, Physiology and Clinical Medicine in 1878. (c)Title of the manuscript, meaning “The finer changes of joint cartilage in fungous synovitis and caries ... have also linked such characteris-tics with synovial fibroblast-like cells of RA patients, whichhave intrinsic invasive properties and thus facilitate thespreading of inflammatory synovial ... und Karies der Gelenk-enden. Archiv Pathol Anat Physiol Klin Med 1878, 73:461-475.5. Sugiyama M, Tsukazaki T, Yonekura A, Matsuzaki S, Yamashita S,Iwasaki K: Localization of apoptosis and expression...
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Báo cáo y học: "The role of statins as potential targets for bone formation" pptx

... 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reduc-tase enzyme. These include naturally occurring lovastatin,chemically modified simvastatin and pravastatin [1–3] andthe synthetically derived atorvastatin, ... vivoeffectsInitial in vivo experiments have shown that statins injectedlocally over the calvaria of normal mice result in a 30–50%increase in calvarial width. This indicates that statins have a direct ... effects of thesedrugs. Mevalonate, farnesyl pyrophosphate and geranyl-Figure 1Cultures of murine neonatal calvaria incubated for either 4 or 7 days in the presence of simvastatin at 1 µM. Small amounts...
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