... five-coordinated hemes in nitrosylhemoglobin: interpretation of electron spin resonance spectra. Biochemistry 15, 4427–4428.30. Perutz, M.F. (1979) Regulation of oxygen affinity of hemoglobin: in uence ... Fasano31Department of Chemistry ‘IFM’, University of Torino, Italy;2Department of Biology, University ‘Roma Tre’, Rome, Italy;3Department of Structural and Functional Biology, University of Insubria, ItalyHaem ... hexa-coordinated,possibly being bonded to His105 and Tyr148 as suggestedby docking simulations [7]. Upon drug binding, neither achange in the haem-iron atom coordination number, nor in the spin state...