... secondary structure of 3'-UTR of cofilin mRNA. The arrow indicates the U-rich signal sequence that could be involved in
the localization of the messenger.
Signal Sequence
Theoretical Biology ... of U-rich mRNAs that could be trans-
ported to the axon. The results show that the secondary
structures of synuclein and cofilin mRNAs are very...
... in models might be the cause of
difference in the results.
In the present study, the abnormal stress on cartilage tissues induced by
joint instability was the main cause of degeneration. The ... point to an important role in
inflammation[9]. Pro-inflammatory signaling mediators such as IL-1 and TNF-α
induce the synthesis of PGE2 by promoting the expression...
... overlapping the active site of the
enzyme, suggesting that this site represents the binding site for Env. Analysis of synonymous and
non-synonymous nucleotide substitutions in the coding sequences of ... affecting the receptor activity of human Hyal2
[5]. To determine if portions of the amino terminus
beyond the signal sequence could be deleted without
affect...
...
that bind to the SH2 domains. The tandem SH2
domains bind to Tyr-627 and Tyr-659 simultaneously
in a specific orientation, in which Tyr-627 binds to the
N-SH2 domain and Tyr-659 binds to the ... biologically plausible
observation would stimulate interest in the study of
the molecular mechanisms of action of this
polymorphism. Because these results were based on...
... As
both the E
a
of inactivation and the temperature at which the
enzyme starts inactivating at a measurable rate increase
from the apoenzyme to the Mn
2þ
-containing enzyme, loss
of the metal cofactor ... cofactor could be the limiting step in BLXI
inactivation. Higher E
a
values of inactivation for the Co
2þ
–
enzyme and the Mn
2þ
–enzyme reflect the higher the...
... machinery, the
common feature being that they cause dephosphorylation
of 4E-BP1 and thus inhibition of eIF4E. In addition to
providing further information on the regulation of a
number of components involved ... consider their effects
on protein synthesis when studying the effects of these
stress conditions on cell physiology. Other agents that
inhibit protein synthesi...
... and bradykinin synthesis, since HA
inhibited their synthesis in a MW-dependent manner [16].
Further, HA has been shown to induce analgesia in a
bradykinin-induced model of joint pain in rats ... may be involved
in cartilage catabolism by inhibiting the synthesis of colla-
gen and PG, enhancing MMP activity, reducing the synthe-
sis of an IL-1 receptor antagonist by chond...
... autoimmune
exocrinopathy of unknown origin. Therefore the diagnosis
of SjS, in the absence of a gold standard, is based on cri-
teria containing a number of subjective and objective
signs and symptoms. In the ... present in SjS sera and that the
majority of these antibodies are of the IgG and IgA class,
but that their frequency in SjS sera is not higher than...
... decision-making process leading to the use
of the specific therapy remains daunting. The issue of the
relative risk for a therapeutic in the context of its relative
benefit should nonetheless continue ... probably the most misunderstood
component in determining therapeutic intervention; however, it is
probably the most relevant issue to consider in the context of...
... application may
be impossible in certain areas of the joint because of
anatomic factors, and the fixation of the periosteal flap or
collagen sheets covering the chondrocyte suspension may
Commentary
A ... It is noteworthy that the histologic
analysis was derived from 18% of the patients who under-
went second-look arthroscopy as a result of grinding,
catching, pain...