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Báo cáo y học: " Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection" ppt

Báo cáo y học:

Báo cáo y học: " Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection" ppt

... Franks NP: Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection. Critical Care 2010, 14:229.Dickinson and Franks Critical Care 2010, ... an interesting possibility.Conclusions e present review summarizes studies on the pharmacology and clinical uses of the inert gases as anesthetics and neuroprotectants. Xenon is the only inert ... protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo. Anesth Analg 2007, 105:562-569.14. Yarin YM, Amarjargal...
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Báo cáo y học:

Báo cáo y học: " Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency" pptx

... for monitoring emphysema in clinical studies of alpha 1-antitrypsin deficiency(AATD) [7,8]. In recent years, there has been greaterunderstanding and acceptance of this relatively noveltechnique, ... and January 2007. Two of the authors of the manuscript (MW and CD) are employees of Talecris and participated in the design of the study, in the col-lection, analysis and interpretation of ... the design of the study, in the analysis and interpretation of data, and drafting of the manuscript.AD was responsible for the Danish arm of EXACTLE and reviewing/contributing to writing the manuscript....
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Báo cáo Y học: Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant doc

Báo cáo Y học: Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant doc

... Efavirenz.Furthermore, wing2 composed of the heterocyclic ringstructure of MSC194 and the substituted pyrimidinefunctionality of PNU142721 occupy the same part of theNNIBP as the benzoaxine-2-one ring of Efavirenz. ... Efavirenz. In asimilar manner, the position of wing1 composed of thesubstituted phenyl ring of MSC194 and the fused ring-structure of PNU142721 overlap the less bulky cyclopropylgroup of Efavirenz.The ... the binding modes of the three inhibitors aresuperimposed in the mutant NNIBP. The cyclopropyl-group of MSC194 and the methyl group of PNU142721partly overlap the trifluoromethyl group of Efavirenz.Furthermore,...
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Báo cáo y học: "A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting" pptx

... week of treatment, 29.0% of subjectswere receiving aripiprazole at doses of ≤5 mg/day; 67.4%were receiving > 5 mg/day and ≤15 mg/day, 3.3% werereceiving >15 mg/day and ≤20 mg/day, and ... effectiveness.Antipsychoticdrugsaretheprimarytreatmentoption for schizophrenia [3] and are increasingly stu-died in real-world settings. Although typical antipsy-chotic agents have a long history of use and ... worsening of metabolic para-meters in this study and, indeed, resulted in improve-ments in cholesterol, triglyceride and fasting plasmaglucose levels at study endpoint compared to baseline....
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Báo cáo y học: "A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis" pptx

... stoichiometric binding of protease inhibitors tothe catalytic site of the activated forms of the enzymes. In thepresent work, we have measured by flow cytometry the netproteolytic activity in synovial ... gelatinase activity of SF was determined as previouslydescribed [15]. The gelatinolytic activity was measured in arbi-trary units by quantitative analysis of a negatively stained bandusing computerized ... the type of arthritis and the level of proteolytic activity. This suggests that, in thecase of arthritis with involvement of several joints, systemicfactors play a dominant role in controlling...
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Báo cáo y học: "Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis" docx

... predictor of CVD [20].Hypertension may be another strong potential link betweenUA and renal dysfunction: induced hyperuricaemia in healthyrats causes hypertension and salt sensitivity [52], ... healthyrats in which mild hyperuricaemia, without crystal deposition,was induced with the use of the uricase inhibitor oxonic acid.This resulted in the development of interstitial renal injury and hypertension, ... estimations included fast-ing lipids, complete serum biochemistry (including UA), fastingglucose, fasting insulin and C-reactive protein (CRP). Refer-ence ranges for UA were established in our Clinical...
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Báo cáo y học:

Báo cáo y học: "The challenge to verify ceramide’s role of apoptosis induction in human cardiomyocytes a pilot study" doc

... outsi de the body before being mounted and tested in the chamber system for a maximum of 30 min, butduring this period the oxygen supply was maintainedcontinuously by bubble-oxygenating the Krebs-Henseleitbuffer ... of ischemia in isolatedcardiomyocyte models can provide important insights intothe pathophysiology of myocardial ischemic injury and itsunderlying molecular mechanisms as was the subject in previous ... Interaction of cera-mide with protein kinase-c can inhibit translocation of the kinase to the plasma membrane and t herefore inhi-bits its catalytic acti vity. Finally the intrinsic and extrin-sic...
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Báo cáo y học: "Severe leukocytoclastic vasculitis secondary to the use of a naproxen and requiring amputation: a case report" ppt

... biopsy pathology high power. Leuko-cytoclastic vasculitis high power view of hemotoxylin and eosin stained skin biopsy. Sections examined in multiple layers show vessels in the upper dermis in ... Leukocy-toclastic vasculitis low power view of hemotoxylin and eosin stained skin biopsy. Sections examined in multiple layers show vessels in the upper dermis in which there is destruction of ... neutrophils secondary toType III hypersensitivity can be augmented through the use of dapsone [19].Bacteremia caused by E. coli secondary to a urinarytract infection delayed the initiation of chemotherapeuticpharmaceuticals...
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Báo cáo y học: " Does psychopathology at admission predict the length of inpatient stay in psychiatry? Implications for financing psychiatric services" ppsx

... basis of daily rates. Thequestion thus arises whether other clinical measurescould better predict LOS in inpatient psychiatry to findways of modifying this cost-determining factor. In view of ... syndrome, psycho-organicsyndrome, manic syndrome, hostility syndrome, vegeta-tive syndrome, apathy, compulsory syndrome, neurologi-cal syndrome. In total, those syndromes consist of 78symptoms ... 0 = nosymptom/mild symptom severity, and 1 = moderate tostrong symptom severity. The severity rating depends onthe intensity and duration of symptoms [14]. In our sta-tistical analyses, we...
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Báo cáo y học:

Báo cáo y học: " Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis B to interferon alfa" ppt

... role of cytokines and the cellular immuneresponse in the pathogenesis and eradication of chronicHBV has been investigated. Several proinflammatorycytokines such as Th1 cytokines (including ... y of the candidate gene in patients with HBV emerges as a probable biomarker fordetermining the disease phenotypes. In HCV infection, the influence of IL-10 genotypeseither on different clinical ... promoter of IL-10 polymorphisms and HBV patients initial response of chronic hepatitis B to IFN- a therapy in Caucasianspatients. In summary, Our findings indicate that heterogeneity in the promoter...
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