... 1667.
doi:10.1186/cc8977
Cite this article as: Abraham E: Inhaled activated protein C: a new therapy
for the prevention of ventilator-induced lung injury? Critical Care 2010,
14:144.
Abraham Critical Care 2010, 14:144 ... 204:2439-2448.
6. Bae JS, Yang L, Rezaie AR: Receptors of the protein C activation and
activated protein C signaling pathways are colocali...
... demonstrate for the first
time that APC administered by the inhaled route may have
benefit in ALI by improving gas exchange. Given the increase
Commentary
Inhaled activated protein C: a novel therapy ... injury (ALI). The benefits of APC therapy in sepsis are
likely due to its anti-coagulant and anti-inflammatory
properties, along with its roles as an anti-apoptotic fa...
... or too
early or late in the course of their disease to have any
advantageofAPC.Comparedtoarecentstudyof55
patients with acute pancreatitis (with a 30-day morta lity
of 27%) [37], the patients ... Organ-failure-free days
alive (ventilator-free days [22], renal replacement ther-
apy-free days, va sopressor-free days), days alive outside
hospital in 60 days, and changes in other labora...
... hyaluronan (hyaluronic acid) and hylans for the
treatment of osteoarthritis: mechanisms of action
Larry W Moreland
University of Alabama at Birmingham, Birmingham, AL, USA
Corresponding author: Larry W ... sources.
Pathophysiology of osteoarthritis
OA is characterized by a slow degradation of cartilage
over several years. In normal cartilage, a delicate balance
exists betwee...
... Care 2007, 13:126-128.
42. Saisana M, Saltelli A, Tarantola S: Uncertainty and sensitivity analysis
techniques as tools for the quality assessment of composite indicators.
Journal of the Royal ... missing value imputation must pro ceed
via a carefully selected strategy appropriate for the data-
set under analysi s. An inappropriate imputati on strategy
may itself introduce bi...
... study.
Statistical analysis
The change of paw withdrawal latency (PWL) for vehicle
and drug treatment groups in the Hargraeve's assay was
calculated. Statistical comparisons between treatment
groups ... in a kinase assay by measuring the amount of phosphorylated
substrate ATF2 using a phosphoATF2 (Thr
71
) specific primary antibody and an alkaline phosphate coupled
second...
... guided
by the clinical response, especially haemodynamic parameters:
the goal should be haemodynamic stability after the
withdrawal of vasoactive agents. Such rational recommen-
dations have already ... not accompanied by an
increase in myocardial oxygen consumption. Myocardial
uptake of glucose increased significantly, whereas uptake of
lactate and free fatty acids was unchanged....
... effector
functions
Clarify the importance of ADCVI activity as a means of
antibody-mediated control of HIV infection; and Define the
key characteristics of antibodies that induce strong ADCVI
activity (e.g. isotype, ... strategy to complement traditional approaches to HIV prophylaxis
and therapy. Importantly, there is increasing evidence to suggest that many arms of the inn...
... primer for the APOPEC3G-UBA2
fusion was 5'-ATCGTACTCGAAGCTTCTAACTCAGGAG-
GAAGTTGGCAG-3'; and the 3' primer for the
APOPEC3G-UBA2* fusion was 5'-ATCGTACTCGAAGCT-
TCTAACTCAGagcGAAGTTGGCAG-3'. ... 5'-ATCCAAGACG-
GAATTCGTTTTCCTGATTCTGGAG-3'. The UBA2 gene
fragment was amplified from plasmid pcDNA3.1-
HHR2 3A by PCR. The 5' primer used was 5&a...
... indicate that axial
wall stress may considerably augment in the segment
immediately proximal to the bridge entrance in the course
of each cardiac cycle. Due to the variability of the many
parameters ... attached to the myocardium, axial forces
of hemodynamic origin cannot induce appreciable cyclic
variations of its length. If the axial forces generated by the
deformati...