Báo cáo y học: "Dividing intensive care specialists according to their backgrounds is not useful to improve quality in intensive care" ppt
Báo cáo y học: "Dividing intensive care specialists according to their backgrounds is not useful to improve quality in intensive care" ppt
... of the optimisation of patient safety.© 2010 BioMed Central LtdDividing intensive care specialists according to their backgrounds is not useful to improve quality in intensive care Jan-Peter ... all physicians in modern-day intensive care medicine: defi n ing, training, maintaining and improving physician compe ten cies, implementation of quality assurance practices and, ultimately, our ... out-come in critical care patients. We caution against propa-gat ing the concept of dividing intensive care specialists according to their backgrounds. Some methodological weaknesses in the paper...
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Báo cáo y học: " Assessing medically unexplained symptoms: evaluation of a shortened version of the SOMS for use in primary care" doc
... underesti-mation of somatoform symptoms [10] has been rein-forced in our study. Although stability of single symptomsor disorders is not satisfactory [17,26], stability of somati-zation seems to be less ... symptoms were only present in somatizers, painful breathing and paralysis/weakness,indicating a high discriminative power, followed by nau-sea (30.8), difficulty in swallowing (28.9), bringing ... ascertained in a clinical interview and by contacting the patient's physicians and examining medical records, attaining a final clinical symptom evaluation (FCSE). An interview yielded...
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Báo cáo Y học: The Emery–Dreifuss muscular dystrophy associated-protein emerin is phosphorylated on serine 49 by protein kinase A pptx
... emerin). This domain is involved in binding to a dsDNA bridging proteintermed BAF (barrier -to- autointegration factor), whichfunctions in higher-order chromatin organization andnuclear assembly ... andpoint towards possible signalling pathways involved in regulating emerin’sfunctions.AbbreviationsAD-EDMD, autosomal dominant Emery–Dreifuss muscular dystrophy; BAF, barrier -to- autointegration ... phosphorylation at resi-due S49 is unlikely to directly regulate emerin-laminA ⁄ C interaction in vivo.Protein kinase A-dependent phosphorylation ofserine 49Computer prediction analysis using...
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Báo cáo y học: "Enhanced expression of interferon-inducible protein 10 associated with Th1 profiles of chemokine receptor in autoimmune pulmonary" pptx
... hematoxylin and eosin; IFN = interferon; IL = interleukin; IP-10 = interferon-γ-inducible protein 10; MIP =macrophage inflammatory protein; PBS = phosphate-buffered saline; PCR = polymerase chain ... mice spontaneously developsystemic lupus erythematosus (SLE)-like disease. The naturalhistory of the pulmonary involvement and the underlyingmechanism of leukocyte infiltration into the lungs ... lupus-like syndrome in myeloproliferativedisease was induced by treatment with IFN-γ [42,43].Similar to the findings of the present study, in sarcoidosis,a disease characterized by a typical cell-mediated...
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Báo cáo y học: "Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis" pptx
... therelease of proinflammatory cytokines and leads to a higherexpression of TLR2. In ankylosing spondylitis (AS), as in other immune-mediateddiseases, an unusual proinflammatory and cytotoxic CD4+ ... diagnosed according to the cri-teria of the American College of Rheumatology [29]. Probandsdid not show any history, clinical or laboratory sign for infec-tions nor malignant diseases. Healthy controls ... hoursat 37°C to allow adherence of contaminating monocytes.Purity of isolated fractions was determined by flow cytometryas already described.Reverse transcription-polymerase chain reactionTotal...
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Báo cáo y học: " A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population" pps
... dis-orders including oligoarthritis, polyarthritis, systemic arthritis,secondary arthritis, and other arthritis types. According to theInternational League of Associations for Rheumatology (ILAR)classification ... oligoarthritis is further subdivided intopersistent and extended oligoarthritis, and polyarthritis is fur-ther subdivided into rheumatoid factor-positive and negativepolyarthritis. Thus, JIA is categorized ... reported by other investigators and estimated the carry-ing rate of each haplotype in the disease populations. Interest-ingly, we found differently genetically skewed haplotypes in each disorder....
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Báo cáo y học: " A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients" doc
... intra-individual variations.Markers that directly reflect the inflammatory activity in the jointwould be useful clinical tools. Cytokines are local proteinmediators known to be involved in almost ... reproduction in any medium, provided the original work is properly cited.AbstractIntroduction Prognosis in rheumatoid arthritis (RA) is difficult to assess. The aim of this study was to examine whether ... Diag-nostics Inc, San Diego, USA), IgM rheumatoid factors by an in- house ELISA and high sensitivity C-reactive protein (hsCRP)was measured by nephelometry (Dade Behring, USA).Cytokine analyses were...
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Báo cáo y học: " T cell receptor transgenic lymphocytes inflitrating murine tumors are not induced to express foxp3" potx
... higher affinity for CCL17 and CCL22 than effector T cells in vitro as determined by a migration assay. Expression of the regulatory cytokine TGFβ is abundant in many tumors, particularly in advanced ... R., et al., Inhibition of cytolytic T lymphocyte proliferation by autologous CD4+/CD25+ regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-beta. Cancer ... (Mouse/Rat/Porcine/Canine TGFβ 1 Quantikine ELISA Kit; R&D Systems) according to the manufacturer's recommendation. Statistical analysis. Statistical analysis and P-value determinations...
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Báo cáo y học: "The self-reported Montgomery-Åsberg depression rating scale is a useful evaluative tool in major depressive disorder" potx
... MADRS-S total score did not discriminate as to whether a patient was suffering from their first episodeof MDD, nor if they had a history of psychiatric hospital-isation, but did discriminate as to ... the improved integration of health-related quality of life assessment in the drug regulatory proc-ess. Drug Inf J 2002, 36:1-10.Pre-publication historyThe pre-publication history for this ... computed. According to Cohen [27], an effect size of at least 0.2 is recommended as the standard for supporting sensitivity to change.Finally, the evaluative ability of the MADRS-S to discrim-inate...
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Báo cáo y học: " Differentiated transplant derived airway epithelial cell cytokine secretion is not regulated by cyclosporine" pdf
... func-tion in a manner similar to that seen in lymphocytes.The ability of AEC to respond to appropriate stimuliwith production of inflammatory mediators despitecyclosporine administration suggests ... pathogenesis of BOS. Our data suggest the possibi-lity that airw ay epithelium may be more than just a tar-getofinjuryinBOSbutmayparticipateincreatingorperpetuating an inflammatory milieu at the interfacebetween ... actual cytokine a ndgrowth factor levels were not assayed [9]. Another limit -ing factor in our observations is that TGF-b1hasashort half-life in acidic environments and thus may not maintain structural...
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