... them concomitantly receiving tenofovir.Five of the 6 cases of lypodystrophy were patients from the “simplification” group and 1 from the “ART-restart”López-Cortés et al. AIDS Research and Therapy ... Research and Therapy 2010, 7:5http://www.aidsrestherapy.com/content/7/1/5Page 6 of 9RESEARC H Open AccessEfficacy, safety and pharmacokinetic of once-dailyboosted saquinavir (1500/100 mg) together ... M, Jupimai T, Ubolyam S, Schutz M, Hirschel B,Staccato Thailand Study Group: Long-term efficacy and safety of first-linetherapy with once-daily saquinavir/ritonavir. Antivir Ther 2008, 13:375-380.8....