Báo cáo y học: "Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury" pdf
Báo cáo y học: "Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury" pdf
... traumatic brain injury and stroke arewidespread and generate an enormous economic and socialburden, we investigated the possible neuroprotective effect in in vitro models of traumatic brain injury and ... effect in both in vitro models of oxygen-glucose deprivation and traumatic brain injury. Our promising results justify further in vivo animalresearch.IntroductionThe first biological effects of ... 1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo[1.1.1] pentyl)-glycine, twomGlu1 receptor-preferring antagonists, reduce neuronaldeath in in vitro and in vivo models of cerebral ischaemia....
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Báo cáo y học: "Vestibulo-ocular monitoring as a predictor of outcome after severe traumatic brain injury" pot
... to the difficulty in detecting diffuse axonal injury[34,35] and lesions of the brainstem [2].Recently, research into the value of imaging for prognosis hasfocussed on the brainstem. Here, Magnetic ... mortality and severe morbidity in young adults in industrialized countries, for example, in Germany 30,000 peo-ple suffer from severe brain trauma each year. A total of 10,000 result in death, and ... GOS 3 and GOS 4 to 5 was made possible by com-bining metabolic (spectroscopy) and anatomic (imaging)brainstem data.It remains, however, that MRI scanning in TBI patient involvesa number of technical...
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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
... Bal1,21Faculty of Chemistry, University of Wroclaw, Poland;2Institute of Biochemistry and Biophysics, Polish Academy of Sciences,Warsaw, PolandA comparative study of thermodynamic and kinetic aspects of ... aspects of Cu(II) and Ni(II) binding at the N-terminal b inding site of human and bovine serum albumins (HSA and BSA,respectively) and short peptide analogues was performedusing potentiometry and ... (1979) So lid phase synthesiswithout repetitive hydrolysis. Preparation o f leucylalanyl-glycyl-valine using 9-fluorenylmethyloxy- carbonylamino acids. Int.J. Peptide Protein Res. 13, 35–42.27....
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Báo cáo y học: " Protocol for a randomised controlled trial of risk screening and early intervention comparing childand family-focused cognitive-behavioural therapy for PTSD in children following accidental injury" pot
... early intervention will assist in reducing symptoms of traumatic stress as well aspreventing chronic disorder and disability in children experiencing acute PTSD following accidental injury.Trial ... emotionalnumbing or avoidance of reminders of that event and physiological hyperarousal. Children and adolescentsmay experience PTSD following exposure to a wide vari-ety of traumatic events, including ... questions remain unanswered,including the importance of parental involvement in treat-ment and optimal timing of interventions.The role of parents in the treatment of PTSD in children and adolescentsThe...
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Báo cáo y học: " Protocol for a randomised controlled trial of risk screening and early intervention comparing childand family-focused cognitive-behavioural therapy for PTSD in children following accidental injury" pptx
... details1Centre of National Research on Disability and Rehabilitation Medicine,School of Medicine, University of Queensland, Herston QLD 4029, Australia.2School of Psychology, University of Queensland, ... controlledtrial of risk screening and early intervention comparing child- and family-focused cognitive-behavioural therapy for PTSD in childrenfollowing accidental injury. BMC Psychiatry 2011 11:15.Submit ... affecting thediagnosis and prediction of PTSD symptomatology in children and adolescents. American Journal of Psychiatry 2006, 163:644-651.3. Scheeringa MS, Zeanah CH, Myers L, Putnam FW: New findings...
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Báo cáo y học: "Argon neuroprotection" potx
... to easily partition into the brain and are able to fi t snugly into amphiphilic binding cavities within proteins [9]. Depending on the properties of the surrounding electrons, some of the noble ... argon may have therapeutic properties for neuronal toxicity by demonstrating protection against both traumatic and oxygen-glucose deprivation injury of organotypic hippocampal cultures in vitro. ... data are of interest as argon is more abundant, and therefore cheaper, than xenon (the latter of which is currently in clinical trials for perinatal hypoxic-ischemic brain injury; TOBYXe; NCT00934700)....
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Báo cáo y học: "Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis"
... Chemical Biology Division, Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland 5. Division of Rheumatology, Department of Medicine, Pennsylvania State ... ecdysone recep -tor plasmid pVGRXR (Invitrogen) into the cells using Lipofectamine (Invitrogen) and PLUS reagent (Invi-trogen). Expression of GFP/NS1 or GFP was induced by the addition of ... Christensen J, Rommelaere J. Initiation of minute virus of mice DNA replication is regulated at the level of origin unwinding by atypical protein kinase C phosphorylation of NS1. J Virol 2001;75(13):5730-9....
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Báo cáo Y học: Ascidian arrestin (Ci-arr), the origin of the visual and nonvisual arrestins of vertebrate pdf
... specificarginine residues (R394 and R396 for b-arrestin2) in b-arrestin that mediate its binding to AP2 were identified[23]. The presence of the clathrin-binding domain and AP2binding site in Ci-Arr ... specifically phosphorylated by G protein-coupled receptor kinases (GRKs) and then bind to arrestinsto preclude the receptor/G protein interaction, resulting in quenching of the following signal ... types of arrestin; visual arrestin expressedexclusively in photoreceptor cells in retinae and pinealorgans, and b-arrestin, which is expressed ubiquitously.Unlike visual arrestin, b-arrestin...
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Báo cáo y học: "eening the human exome: a comparison of whole genome and whole transcriptome sequencing" pot
... homozygous in gDNA and yet heterozygous in cDNA, and the median coverage for these SNVs in gDNAwas only 12×, compared to 28× for SNVs that matchedfor zygosity. It is likely that many of the ... SNVs in pro-tein-coding exons in gDNA and 64,128 in cDNA. Of these, 48,740 in gDNA and 40,605 in cDNA passed qual-ity control filters, and 19,054 of these overlapped betweenthe two datasets in ... be of some use. For example, data from Heinzen et al. [6]revealed an r2 of 0.23 between transcript expression in PBMCs and in brain, and that 63% of the transcriptshighly expressed in brain...
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Báo cáo y học: "Celiac disease as a potential cause of idiopathic portal hypertension: a case report" pdf
... immunity is impor-tant, with increased CD8 T lymphocytes and inflamma-tory cytokines (notably INFγ and IL-10) found in involvedtissues [13,14]. IPH may represent aberrant immuneactivity, triggered ... coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in child-hood celiac disease. Gastroenterology 2002, 123:667-678.14. Alaedini A, Green PH: Autoantibodies in celiac ... image of the duodenal mucosal biopsyFigure 1Microscopic image of the duodenal mucosal biopsy. Duodenal mucosal biopsy showing subtotal villous atrophy, lymphocyte infiltration and crypt hyperplasia.Publish...
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