... phosphorylation of tyrosine Y5 81 creating a more favourable conformation of thesequence surrounding the tyrosines Y5 79 and Y5 81, therebyincreasing binding affinity. Interestingly, the EpoR contains a ... providing an additional contact withthe SH2 domain of SOCS-3 involving R94. A conforma-tional change induced by the phosphorylation of tyrosine Y4 31 may also contribute to the increase in binding affinitycompared ... domain that inhibits JAK kinases. Nature 387,921–924.7. Naka,T.,Narazaki,M.,Hirata,M.,Matsumoto,T.,Minamoto,S., Aono, A. , Nishimoto, N., Kajita, T., Taga, T., Yoshizaki, K.,Akira, S. &...