... from Genzyme (Cam-bridge, MA, USA), and recombinant human TNF-α and recom-binant human IL-17 were from R&D Systems (Minneapolis,MN, USA). Prostaglandin E2 (PGE2) was from Cayman Chem-ical ... to inhibitthe expression of several inflammatory and catabolic genes in cultured chondrocytes [4,11,12] and to exhibit anti-inflamma-tory and chondroprotective effects in an experimental animalmodel ... protein kinases and tyrosine kinases on IL-1-induced NF-κB activation and iNOS expression in bovinearticular chondrocytes. Nitric Oxide 2002, 6:35-44.40. Liacini A, Sylvester J, Li WQ, Huang...