... diseasesHirofumi Shoda1, Keishi Fujio1, Yumi Yamaguchi1, Akiko Okamoto1, Tetsuji Sawada1, Yuta Kochi2 and Kazuhiko Yamamoto11Department of Allergy and Rheumatology, Graduate School of ... relationship with the proinflammatorycytokines, especially TNFα, and this relationship may be one of the main mechanisms by which IL-32 promotes inflamma-tion. Indeed, the proinflammatory effects of ... inflammatory cytokines and promotes osteoclastogenesis to destroy the bones. TNFαtransgenic mice develop inflammatory arthritis spontaneously[1]. Moreover, TNFα inhibition decreases the severity of...