Báo cáo y học: " The Basic Immune Simulator: An agent-based model to study the interactions between innate and adaptive immunity" doc
Báo cáo y học: " The Basic Immune Simulator: An agent-based model to study the interactions between innate and adaptive immunity" doc
... purposes)Theoretical Biology and Medical ModellingOpen AccessSoftware The Basic Immune Simulator: An agent-based model to study the interactions between innate and adaptive immunityVirginia ... contributorsAbstractBackground: We introduce the Basic Immune Simulator (BIS), an agent-based model created to study the interactions between the cells of the innate and adaptive immune system. Innate immunity, ... Lymphocytes, ADAPTIVE, humoral immunity, makes antibodies(Antibody 1) Ab1 Cytotoxic and neutralizing antibody(Antibody 2) Ab2 Targeting and neutralizing antibodyComplement Bound antibody...
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Báo cáo Y học: Biosynthesis of vitamin B2 An essential zinc ion at the catalytic site of GTP cyclohydrolase II ppt
... biosyn-thetic pathways of tetrahydrofolate and tetrahydrobiopterin[3,4]. GTP cyclohydrolase II catalyzes the hydrolytic releaseof C8 of GTP accompanied by the release of pyrophosphatefrom the ... Germany;2Lehrstuhl fu¨rAnorganische und Analytische Chemie, Technische Universita¨tMu¨nchen, Garching, GermanyGTP cyclohydrolase II catalyzes the hydrolytic releaseof formate and pyrophosphate ... retained the capacity to releasepyrophosphate from GTP and from the formamide-typeintermediate analog. The data suggest that the enzymecatalyzes an ordered reaction in which the hydrolytic releaseof...
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Báo cáo Y học: Calcium-binding by p26olf, an S100-like protein in the frog olfactory epithelium pot
... solution.In order to determine the affinity for Ca21 and the cooperativity of Ca21-binding to p26olf, we next analyzed the stoichiometry of Ca21-binding to p26olf by flow dialysisin the Tris buffer. ... sequentially, and has a total of four Ca21-bindingsites (known as EF-hands). In this study, to elucidate the mechanism of Ca21-binding to each EF-hand (named EF-A,-B, -C and -D from the N-terminus ... suggested that the orderof Ca21-binding to p26olf is EF-B, EF-A, EF-C and EF-D.In these EF-hands, EF-B and -D are the p26olf-specificEF-hands and probably show high affinity for Ca21-binding,while...
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Báo cáo y học: "A randomized, double-blind, placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic stress disorder" pot
... therapy (TFCBT), stress management, other ther-apies (supportive therapy, nondirective counseling, psy-chodynamic therapy, and hypnotherapy), group cognitivebehavioral therapy and eye movement ... prognosis [2]. The development of treatments for PTSD is challengingdue to the complexity of the symptoms and psychiatriccomorbidities. Psychotherapy and pharmacotherapy are the two main classes ... compare the efficacy of topiramate with pla-cebo in the treatment of PTSD, and will study its tolerabil-ity through the drop out rate in each group. The primaryhypothesis is that topiramate...
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Báo cáo y học: "Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma" pps
... the extent and nature of disease heterogeneity; the frequency of the high-risk allele and the concomitant attributable risk; the pene-trance of a specific allele; and the ability to define a ... likely to be offset by the need forvery large sample sizes and a substantial penalty neces-sary to correct for multiple comparisons. Further limita-tions come from the cost of typing the very ... asthma and atopy. The most investigated candidate location for atopy and asthma susceptibility loci has been the 5q31–33 region[88–90], because it contains a large number of importantcandidate...
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Báo cáo y học: " Identification of restriction endonuclease with potential ability to cleave the HSV-2 genome: inherent potential for biosynthetic versus live recombinant microbicides" pdf
... example, the T-evencoliphage DNA contains not cytosine but 5-hydroxymeth-ylcytosine, and most of the hydroxymethylcytosine resi-dues in these DNAs are glycosylated as well [20]. The genome of the ... and hydroxyl ions in the glycolic and lactic acids monomers of PLGA towards the hydroxyl and hydrogen ions in the N-9 and the REase nanoparti-cles model. The underlined dots signify that it ... of both humans and animals such as1.0% Savvy (C31G) [28]; and plant derivative like Pra-neem polyherbal suppository and gossypol may serve the purpose. Note that meta-analysis of randomized...
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Báo cáo y học: "Tiling microarray analysis of rice chromosome 10 to identify the transcriptome and relate its expression to chromosomal architecture" pptx
... Comparison of the S Arrays and the N Arrays using the BGI japonica annotation. Log2 (S/N) of the hybridization intensity was calculated for individual models (top) and the mean intensity of all models ... TE models was not assessed. The nonredundant models were further divided into CG, EG and UG models based on their alignment to rice full-length cDNAs and ESTs and their expression assessed by ... page)Comparison and integration of chromosome 10 gene models. (a) Number of annotated and array-detected high homology (HH) and low homology (LH) models in the BGI indica, BGI japonica, and TIGR japonica annotations....
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Báo cáo y học: ": Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility" docx
... mice and tumor samples and KKL performed arrayanalysis for the confirmation study. Taqman assays were performed by JS.Array CGH data were provided by DGA. The paper was written by DAQ and AB.Received: ... (FIS)/FEDER,MICIIN/plan-E 2009, JCyL (’Biomedicina y Educación’) and CSIC. The fundershad no role in study design, data collection and analysis, decision to publish,or preparation of the manuscript. We thank ... 37007-Salamanca, Spain.Authors’ contributions The study was conceived and supervised by AB. Bioinformatics analysis wasperformed by DAQ. RNA and DNA extraction was performed by IK, KKL, and MDT....
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Báo cáo y học: "Coronary artery bypass surgery in a patient with Kartagener syndrome: a case report and literature review" doc
... proximal stenosis of90% in the circumflex artery and a stenosis of 99% between the proximal and middle part of the right cor-onary artery. The ejection fraction w as normal and the aortic valve was ... University Hospital Alexandroupolis, 68100,Greece.2Dpt of Cardiovascular and Thoracic Surgery, University HospitalGoettingen, Germany.3Dpt. of Anesthesiology. University HospitalAlexandroupolis, ... was the author. LL, BD and DM contributed to literature research. VD was the surgeon and supervisor. SE was the anesthetist. GB made corrections and consultation. All authors read and approved the...
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Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx
... be due to apartial and temporally-limited inactivation of JAK/STATpathway by PTPH1 deletion. Further biochemical analy-sis are necessary to confirm this hypothesis and to under-stand the possible ... contributions The study was devised by CP and VM and carried out by CP. DL performed the behavioral tests (Von Frey, Hargreaves and Catwalk) on PTPH1-WT and KO ani-mals. VM, BG and RH have been deeply involved ... randomized between KO and WT animals, and all apparatus were thoroughly cleaned between twoconsecutive test sections.Cytometric beads Array (CBA)At the end of both inflammatory models, a panel...
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