Báo cáo y học: "A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose" pptx
Báo cáo y học: "A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose" pptx
... indicates that DNA repair pathwaysare a key determinant of cell survival after radiation, andthat targeting the molecular components of these path-ways offers therapeutic potential [1-3].When assessing ... modifiers on radiation sensitivity assume a constant effect independent of the radiation dose received. The aim of this study was todevelop and evaluate a modelling strategy by which radiation dose ... indicator whichassumes the value zero for the control case, i.e. radiation alone, and one for the drug-treated case; and δx – where"x" is any of the parameters above – is the variation...
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Báo cáo y học: "An optimization framework for unsupervised identification of rare copy number variation from SNP array data." doc
... Circular binarysegmentation for the analysis of array-based DNA copynumber data. Biostatistics 2004, 5:557-572.20. Venkatraman ES, Olshen AB: A faster circular binary segmenta-tion algorithm for ... assign a classvalue from C to each marker on a genome based on the Ri val-ues such that the class assignment of consecutive markersand their raw copy number estimates are as consistent as ... Affymetrixplatform, Illumina arrays, or array comparative genomichybridization. Any platform that produces a measure of rawcopy number at markers across the genome would be suita-ble. As SNP arrays continue...
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Báo cáo y học: " Research Mathematical framework for human SLE Nephritis: disease dynamics and urine biomarkers" pdf
... orimmunosuppressants can trigger these salutary effects. Lastly, the anti-inflammatorytherapy is simulated as any drug/event leading to an increase of anti-inflammatory medi-ators, modeled here by the ... si, for instance, may vary greatly during the flare cycle (changes in therapy, therapy failure orsuccess), and can also vary greatly from patient to patient (stages of disease, general patient ... anti-inflammatory drugs. The anti-inflammatory therapy is mathematically modeled here byadding a source term s a in the equation for A. There is also intrarenal production of anti-inflammatory mediators,...
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Báo cáo y học: "Maternal Smoking in Pregnancy: Do the Effects on Innate (Toll-Like Receptor) Function Have Implications for Subsequent Allergic Disease" pps
... Tan A, Iasvovskaia S, et al. Ras and mitogen-activatedprotein kinase kinase kinase-1 coregulate activator protein-1- andnuclear factor-kappaB-mediated gene expression in airway epithe-lial ... these effects may not only contribute to the increased risk of infection2but may also be implicatedin the increased rates of other forms of chronicinflammatory respiratory disease seen in these ... components. Activation of APCs through the TLR also has implications for adaptiveimmune function as these cells play a critical role inprogramming effector responses. Once activated via thesepathways,...
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Báo cáo y học: " Does respiratory health contribute to the effects of long-term air pollution exposure on cardiovascular mortality?" pot
... co-investigator of the repeated cross-sectional studies, performed the Geograph-ical Information System analysis, performed the statisticalanalysis and was responsible for the data management.UK was ... ratios (RRc) demonstrate that cardio-vascular death was associated with impaired respiratoryhealth and unfavourable lung function values. The associ-ation between cardiovascular mortality ... risk ratio at the age of 67 years declined near the null value (table 3).Respiratory health indicators as additional covariates for the association between air pollution exposure and cardiovascular...
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Báo cáo y học: " Individual mRNA expression profiles reveal the effects of specific microRNAs Amit Arora and David AC Simpson" pot
... Rauhut R, Meyer J, Borkhardt A, Tuschl T: NewmicroRNAs from mouse and human. RNA 2003, 9:175-179.52. Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tom-ida S, Yatabe Y, Kawahara ... conceived the study. AA collected the data and per-formed the data analyses. DACS and AA interpreted the results. DACS drafted the manuscript with assistance fromAA. Both authors read and approved the ... Parkinson H, Kapushesky M, Shojatalab M, Abeygunawardena N,Coulson R, Farne A, Holloway E, Kolesnykov N, Lilja P, Lukk M, ManiR, Rayner T, Sharma A, William E, Sarkans U, Brazma A: ArrayEx-press...
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Báo cáo y học: "Endoscopic Facet Debridement for the treatment of facet arthritic pain – a novel new technique
... Length of fol-low-up was at least 3 years with a maximum of 6 years. Location of facet pain was cervical in 45, tho-racic in 15, and lumbar in 114 patients. Surgical times varied based on the ... outcome measure was percent change in facet-related pain as measured by Visual Analog Scale (VAS) score at final follow-up visit. Secondary outcome was change in OSWESTRY disability index from ... durable for at least 3 years. Larger scale trials with a control group are warranted to further evaluate the relative efficacy of this surgical treatment in patients with facet joint disease....
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Báo cáo y học: " Off-label indications for atypical antipsychotics: A systematic review" doc
... data to warrant the use of these agents in a broad spectrum of psychiatric disorders, either as monotherapy, or as anaugmentation strategy.IntroductionNewer antipsychotic agents exhibit a ... sufficient hard data to warrant the use of these agents in a broad spectrum of psychiatricdisorders, either as monotherapy, or as an augmentationstrategy.Conflict of interestNone declared.References1. ... apply low doses of antipsychot-ics to a variety of refractory non-psychotic patients,already during the pre-atypical era.Published: 18 February 2004Annals of General Hospital Psychiatry 2004,...
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Báo cáo y học: " laboratory driving simulation for assessment of driving behavior in adults with ADHD: a controlled study" docx
... aspect of driving behavior was measured as a proxy of hyperactivity. Lane position was measured as the variabil-ity of the driver's position within lane. Reaction time wasmeasured as the ... Biederman had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.References1. Faraone S, Biederman J, ... Had full access to all the data in the study and takeresponsibility for the integrity of the data and the accuracy of the data analysis. I am also responsible for editing the final draft.RF:...
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Báo cáo y học: "Self-help interventions for depressive disorders and depressive symptoms: a systematic review" pdf
... included in the meta-analysis of lighttherapy for depression, eight for light therapy for SAD,and five for dawn simulation for SAD. The meta-analysesrevealed a large effect of light therapy (d = ... lookedexclusively at light therapy for non-seasonal depressionand applied broader inclusion criteria for trials [163]. A total of 18 RCTs were analysed, however only 2 used lighttherapy as the only treatment. ... exercise, yoga/meditation, massage, and relaxation were rated highlyand as strongly as professionally recommended strategiessuch as CBT and SSRIs. Another approach is to developconsensus of experts...
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