Báo cáo y học: "Inhaled activated protein C: a novel therapy for acute lung injury" pot
Báo cáo y học: "Inhaled activated protein C: a novel therapy for acute lung injury" pot
... Waerhaug andcolleagues [1] test the hypothesis that inhaled activated protein C (APC), a novel therapy approved for the treatmentof severe sepsis [2], may be an effective treatment for acute lung ... demonstrate for the firsttime that APC administered by the inhaled route may havebenefit in ALI by improving gas exchange. Given the increaseCommentaryInhaled activated protein C: a novel therapy for ... coagulation and inflammation. Therefore, Waerhaugand colleagues hypothesized that administration of activated protein C (APC) via the inhaled route would be a novel andeffective treatment for ALI....
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Báo cáo y học: "Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury" docx
... 1667.doi:10.1186/cc8977Cite this article as: Abraham E: Inhaled activated protein C: a new therapy for the prevention of ventilator-induced lung injury? Critical Care 2010, 14:144.Abraham Critical Care 2010, 14:144 ... 204:2439-2448.6. Bae JS, Yang L, Rezaie AR: Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci U S A 2007, ... inhaled APC can prevent or minimize primary or secondary lung damage when low tidal volumes are used for mechanical ventilation.AbbreviationsAPC, activated protein C; ERK, extracellular-regulated...
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Báo cáo y học: " APCAP - activated protein C in acute pancreatitis: a double-blind randomized human pilot trial" ppsx
... 9:321-322.17. Bradley EL: A clinically based classification system for acute pancreatitis.Summary of the international symposium on acute pancreatitis, Atlanta,Ga, September 11 through 13, 1992. Arch ... ther-apy-free days, va sopressor-free days), days alive outsidehospital in 60 days, and changes in other laboratoryvalues during the first five days.Radiologic assessmentAn abdominal CT-scan ... acute pancreatitis. Arch Surg 2006,141:670-676.8. Chen P, Zhang Y, Qiao M, Yuan Y: Activated protein C, an anticoagulantpolypeptide, ameliorates severe acute pancreatitis via regulation ofmitogen-activated...
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Báo cáo y học: "Mathematical modelling to centre low tidal volumes following acute lung injury: A study with biologically variable ventilation" doc
... BT, Schoenfeld D, Anzueto A, Matthay MA:Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome.Am J Respir Crit Care Med 2002, 165:978-982.29. ... Industrial Mathematical Sciences, University of Manitoba, Winnipeg, Manitoba, Canada and 3Department of Pathology and Laboratory Medicine, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary ... periods.Mean Peak and Mean Airway Pressure for the Two GroupsFigure 6Mean Peak and Mean Airway Pressure for the Two Groups. Mean values for peak and mean Paw for Control (diamond) and Experimental...
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Báo cáo y học: "Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury" potx
... drugconcentration is necessary, particularly with changes in drugdose and clinical status.Second, metabolites may accumulate with AKI. Be aware ofpotential pharmacologically active metabolite accumulationwith ... even hepatically eliminateddrugs and formed drug metabolites may accumulate during AKI,and renal replacement therapy may affect nonrenal clearance aswell as drug metabolite clearance.IntroductionThe ... signifi-cantly lower PAH clearance.Although the role played by OATs in nonrenal drug clearancehas not been characterized, decreased OAT1 and OAT3activity as a result of AKI could decrease the renal...
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Báo cáo Y học: Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression pdf
... luminometer (EG &G Berthold, Bad Wildbad, Germany), and expressed inarbitrary units.Statistical analysisOne- or two-way analysis of variance, as appropriate, andTukey's test were performed ... acetylcholine (ACh)from choline and acetyl coenzyme A is catalyzed by theenzyme choline acetyltransferase (ChAT, acetyl-CoA:cho-line O-acetylotransfe rase, EC 2.3.1.6) [1]. Following syn-thesis, ACh ... Mitogen -activated protein kinase kinase negatively modulatesciliary neurotrophic factor -activated choline acetyltransferasegene expressionTiffany Mellott1, Ignacio Lopez-Coviella2, Jan Krzysztof...
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Báo cáo y học: " Mitogen-activated protein kinases and NFκB are involved in SP-A-enhanced responses of macrophages to " pdf
... 4°C for immedi-ate use or -20°C for long-term storage. The SP -A was ana-lyzed for purity by SDS-PAGE and for endotoxincontamination using the Limulus amebocyte lysate assay(Associates of Cape ... intracellular kinases. Studies with Leishmaniahave shown that entry of organisms into non -activated macrophages is accompanied by activation of protein tyrosine phosphatases that inactivate MAP kinasesthrough ... these pathways are activated by BCG alone and that opsonization of BCG with SP -A leads to enhanced activation of both pathways, contribut-ing to increased intracellular BCG killing.Materials and...
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Báo cáo khoa học: "Recombinant activated protein C: the key is clinical assessment of risk of death, not subset analysis" potx
... as anAPACHE [Acute Physiology and Chronic Health Evaluation] IIof ≥ 25’. APACHE II ≥ 25 was used as one marker of high riskof death because a subset data analysis demonstrated thatthe treatment ... Page 1 of 2(page number not for citation purposes)ADDRESS = Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis; APACHE = Acute Physiology and Chronic Health Evalu-ation; ... trial waspredominantly in this group of patients. The Europeanregulatory body approved rhAPC for multiple organ failure(again based on subset data analysis from the PROWESStrial demonstrating...
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Báo cáo khoa học: " Recombinant activated protein C in sepsis: endothelium protection or endothelium therapy" docx
... beenidentified as participating in the anticoagulant activity but notin cellular effects. Hence, variants have been designed withgreater anti-apoptotic activity and reduced anticoagulantactivity relative ... endothelium therapy Clearly, in cellular and animal models, rAPC has been giveneither as a pre-treatment or concurrent with septic challenge.This mode of administration favours the anti-inflammatoryeffects ... Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF,Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, ElyEW, Fisher CJ Jr: Efficacy and safety of recombinant human activated protein C for severe...
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Báo cáo y học: "High-Resolution Flow Cytometry: a Suitable Tool for Monitoring Aneuploid Prostate Cancer Cells after TMZ and TMZ-BioShuttle Treatment"
... permanent radioactive implants (brachytherapy) [7]. iv) The standard initial systemic therapy for locally advanced or metastatic disease is hormonal or androgen depri-vation therapy (ADT) that ... Nagahara S, Makita N, Tarumi Y, Kadomatsu K, and Takei Y. Systemic delivery of siRNA specific to tumor mediated by atelocollagen: Combined therapy using siRNA targeting Bcl-xL and cisplatin against ... Suyama T, Sakamoto S, and Ichikawa T. Bisphosphonate and low-dose dexamethasone treatment for patients with hormone-refractory prostate cancer. Hinyokika Kiyo 2006; 52: 515-521 16. Abratt...
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