... 20) and interday (n = 200) coefficients ofvariance for each biomarker were, respectively: for C2C, 10 – 17 % and 14 %; for C1,2C, 5 14 % and 13 %; for CS 846 -epitope, 4 12 % and 12 %; and for CPII, 11 18 % ... differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosisSMM Verstappen 1 , AR Poole2, M Ionescu2, LE King3, M Abrahamowicz 4 , ... destruction can occur within a few years after dis-ease onset [4] . Radiographs only reveal gross anatomicalchanges. It usually takes at least one year before significantchanges in joint damage can be...