Báo cáo y học: "A plague on five of your houses – statistical reassessment of three pneumonic plague outbreaks that occurred in Suffolk, England, between 1906 and 1918" pdf
Báo cáo y học: "A plague on five of your houses – statistical reassessment of three pneumonic plague outbreaks that occurred in Suffolk, England, between 1906 and 1918" pdf
... AccessA plague on five of your houses – statistical re-assessment of three pneumonic plague outbreaks that occurred in Suffolk, England, between 1906 and 1918Joseph R EganCorrespondence: joseph.egan@hpa.org.ukMicrobial ... previously analysed historical outbreaks of pneumonic plague to better understand the dynamics of infection,transmission and control. This study examines 3 relatively unknown outbreaks of pneumonic plague ... statistical re-assessment of three pneumonic plague outbreaks that occurred in Suffolk, England, between 1906 and 1918. Theoretical Biology and Medical Modelling2010 7:39.Submit your next manuscript...
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Báo cáo Y học: A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor potx
... phosphorylation of tyrosine Y5 81 creating a more favourable conformation of thesequence surrounding the tyrosines Y5 79 and Y5 81, therebyincreasing binding affinity. Interestingly, the EpoR containsa similar ... compared to the binding mode of pY429pY431 withpY431 binding into the classical pY-binding pocket and F429 (position Y) 2) filling the gap created by G53 of theSH2 domain. In the context of the activated ... domain of SOCS-3 involving R94. A conforma-tional change induced by the phosphorylation of tyrosine Y4 31 may also contribute to the increase in binding affinitycompared to the single phosphorylated...
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Báo cáo y học: " A QTL on mouse chromosome 12 for the genetic variance in free-running circadian period between inbred strains of mice" potx
... promoterregion of mPer1 contains targets for zinc finger proteinbinding and is essential in NG10 8–1 5 cells for CaMkinase II-induced gene-activation [44]. Furthermore,mouse LARK protein not only contains ... following: non-synonymous codingSNPs: gene expression differences between B6 and D2 in whole brain; cis- and trans-regulation of expression; and circadian gene expression. Several studies integrate ... (arylhydrocarbon receptor) and Zfp277 (zinc finger protein 277) both containnon-synonymous SNPs. Zfp277 also showed differential expression in whole brain and was cis-regulated. Three genes and one predicted...
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Báo cáo y học: " A predictive model for respiratory syncytial virus (RSV) hospitalisation of premature infants born at 33–35 weeks of gestational age, based on data from the Spanish FLIP study" pdf
... Study Group:Case-control study of the risk factors linked to respiratorysyncytial virus infection requiring hospitalisation in prema-ture infants born at a gestational age of 3 3–3 5 weeks in Spain. ... improve standards of care by better identifying highrisk infants and, thus, optimising prophylaxis. It may alsobe used to inform guidance and to help clarify the justifi-cation of funding and reimbursement ... Bacheyie GS, Onyett H, Michaliszyn A, Manzi P, Parison D: Thepediatric investigators collaborative network on infections in Canada study of predictors of hospitalization for respiratorysyncytial...
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Báo cáo y học: " A reflection on HIV/AIDS research after 25 years" pot
... 25 yearsRobert C Gallo*Address: Institute of Human Virology, University of Maryland Biotechnology Institute and Department of Microbiology and Immunology, University of Maryland School of ... unknowinglysent us a very different strain of HIV that grows well in celllines. This strain contaminated his culture of LAV before itcontaminated one of ours.Then, from all sides and in big ... theseadvances in understanding and in conscience will con-tinue to evolve and grow so that there will be no need foranyone to reflect on AIDS in its 50th birthday year.Retrovirology 2006, 3:72...
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Tài liệu Báo cáo Y học: A novel, inducible, citral lyase purified from spores of Penicillium digitatum docx
... determined bymeasuring acetaldehyde during the conversion of differentconcentrations of citral (0.02 2–0 .556 mM). The initialactivities of the conversions were plotted in a Lineweaver–Burk ... best of ourknowledge, the induction of an enzymatic activity in nongerminating spores has so far only been described in spores of Aspergillus oryzae,i.e.a-amylase, invertase and glucose dehydrogenase ... dependence of the conversion was determined byvarying the pH form 5.6 6–1 0.19 (by adding 0.8 mL of 0.1Mbuffer to 0.2 mL of purified enzyme). The exact pH duringFig. 1. Reaction catalysed by citral lyase,...
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Báo cáo Y học: A single charged surface residue modifies the activity of ikitoxin, a beta-type Na+ channel toxin from Parabuthus transvaalicus doc
... Na+channels of central neurons. It is our conclusion that the N-terminal loop preceding the a-helix in scorpiontoxins is one of the determinative domains in the interaction of toxins with the target ion ... analysis, matrix solutions consisting of sinapinic acid, 3,5-dimethoxy-4-hydroxycinnaminic acid,or a-cyano-4-hydroxycinnamic acid, were mixed in a 1 : 1ratiowithsamples,spottedonthetargetandallowedtodry.MASSLYNX(Micromass ... determinants of high affinity binding of a-scor-pion toxin and sea anemone toxin in the S3–S4 extracellular loop in domain IV of the Na+channel a subunit. J. Biol. Chem. 271,1595 0–1 5962.15. Jones,...
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Báo cáo y học: "A mouse embryonic stem cell bank for inducible overexpression of human chromosome 21 genes." ppsx
... overexpressed in an inducible manner. Each clone was transcriptionally profiled in inducing versus non-inducing conditions. Analysis of the transcriptional response yielded results that were consistent ... modified, in the region between XhoI and NotI restriction sites, by adding a mul-tiple-cloning site that contains sequences recognized by three restriction enzymes (I-SceI, AscI and PacI) and byadding ... deficit in tumour angiogenesis arising fromsuppression of the calcineurin pathway [12]. Overexpres-sion of a number of HSA21 genes, including Dyrk1a,Synj1 and Sim2, results in learning and memory...
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Báo cáo y học: "A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens" pptx
... Thus Hsp70 in addition to chaperon-ing peptides into the antigen processing pathway of iDC,may also trigger IFN-γ production in a similar way to that of LPS [46-49]. These findings are in agreement ... sameprocedure.Isolation of monocytes and lymphocytes and generation of immature DCsBuffy coat packs from healthy female donors wereobtained from the Irish Blood Transfusion Service.PBMCs were prepared by Lymphoprep ... and Ursula Bond*†1Address: 1Moyne Institute for Preventive Medicine, Department of Microbiology, University of Dublin, Trinity College, Dublin 2, Ireland, 2Institute of Immunology & Department...
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Báo cáo y học: " A highly attenuated recombinant human respiratory syncytial virus lacking the G protein induces long-lasting protection in cotton rats" pot
... Pulmonary lesions in primary respiratory syncytial virus infection, reinfection, and vaccine-enhanced disease in the cotton rat (Sigmodon hispidus). Lab Invest 1999, 79:1385-1392.17. Jin H, ... Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactivated virus. J Virol 1986, 57:721-728.16. Prince GA, Prieels ... Variations in intergenic region sequences of Human respiratory syncytial virus clinical isolates: analysis of effects on transcriptional regulation. Virology 2004, 327:121-133.19. Karron RA, Buonagurio...
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