... 2002 Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin Jae-Hoon Kim1,*, Kazuki Saito1,2 and Shigeyuki ... N- and C-terminal parts of the ligand are cross-linked to domainsI and III, respectively, of the receptor [19,22]. The b sheet of EGF may bind to domain I of ErbB-1, and the other surface of the ... contributions of the domains of ErbB-1 to the EGFsignaling and those of ErbB-4 to the NRG signaling. Analyses using chimeric receptors are very useful toelucidate the relative contributions among the...