Báo cáo y học: "Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain" pptx

... Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the ... administration in both SAMP8groups. These findings raise the possibility that agingreduces the function of the PDGF/PDGFR signalingsystem and that recovery of this system may play arole in the ... likely inducea decrease in angiogenesis and neuronal signaling in the brain and are implicated in aging-induced cognitive defi-cits in SAMP8. Considering a role of the VEGF-VEGFR2 signaling systems...

Báo cáo y học: "A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy" pps

... organs.9 The purpose of this study was to evaluate the safety and efficacy of oral Apatone administered throughout the day in prostate cancer in patients who failed standard therapy. Int. J. ... months and 11 continued for at least 1 year with one patient continuing for more than 2 years. Therapy was not discontinued in any patient due to vitamin toxicity or for other safety reasons. The ... failed standard therapy were enrolled at William Beaumont, Royal Oak, MI and Summa Health Systems, Akron, OH. Standard therapy was defined to include radical prostatectomy, radiotherapy and hormonal...

Báo cáo y học: "Oesophageal Perforation: A diagnostic and therapeutic challenge in a resource limited setting. A report of three cases." ppsx

... caused by; attempted foreign bodyremoval either by a poorly trained endoscopist, or byone who tries to push the foreign body a head of the endoscope in to the stomach too vigorously[2] or byusing ... institute and very effec-tive without the side effects of the expensive and una-vailable intravenous nutrition. The insertion of the feeding gastrostomy tube in our setting was by the tech-nique ... used initially, as it maycause further injury at the site of perforation [3]. In oursetting enteral nutrition, through a feeding gastrostomyis preferred, because it is easy to institute and...

Báo cáo y học: " A novel duplex real-time reverse transcriptase-polymerase chain reaction assay for the detection of hepatitis C viral RNA with armored RNA as internal control" docx

... assay.Intrinsic performance of the duplex real-time RT-PCR assayLinearityLinearity of the duplex real-time RT-PCR assay wasdetermined using serial 10-fold dilutions of a clinicalsample at the ... primer/probe assays in the testing of the same serum sample. Obviously, the fluores-cence value of the 2 sets of primers/probes is higher thanthat of the single set of primers/probes, and cycle thresh-old ... confidence interval, 29.4-83.55 IU/ml).Specificity The specificity of the duplex real-time RT-PCR assay was100% in the testing of the HCV-negative serum samples.Reproducibility The intra-assay variation...

Báo cáo y học: "Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment" pot

... chains in these tissues are connected by 3-hydroxypyridinium crosslinks, which become discharged and excreted as pyridinoline upon disintegration of collagen [19].Levels of urinary pyridinoline ... reduction of urinary pyridinoline,indicating an inhibition of the ongoing, inflammation-mediatedbreakdown of collagen. If translated into clinical practice, sucha feature would offer a window ... reduction of pyridinoline, a marker for bone and cartilage degradation.Such reduction of pyridinoline provides additional proof of the strong therapeutic activity of liposomal DXM-P and correlatesto...

Báo cáo y học: " Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered" pptx

... proteolysis in cultured L6myotubes. Shock 1998, 10:298-306.39. Yin HN, Chai JK, Yu YM, Shen CA, Wu YQ, Yao YM, et al: Regulation of signaling pathways downstream of IGF-I/insulin by androgen in ... are among the most widely used drugs in the world and are effective in the treatment of manyinflammatory and immune diseases. However, one of the main side-effects of systemically administered ... an increase in muscle mass probably mediated by inhibition of muscleproteolysis rather than by stimulation of muscle proteinsynthesis [27]. Inhibition of muscle proteolysis, in parti-cular the...

Báo cáo y học: "Mast cell tumours and other skin neoplasia in Danish dogs - data from the Danish Veterinary Cancer Registry" potx

... current study surgery was per-formed in 73% of the MCT cases in the DVCR suggest-ing that cases of MCT are treated according to the recommendations at the participating veterinary clinics.Treatment ... veterinary studies the majority of the skinneoplasms were benign as in the current study[1,2,4,10]. In the Norwegian study [1], the most common malig-nant neoplasia types wer e MCT (45.4% of ... management and statistical analysis, participated in designing the study, evaluating results, researching background literature and drafting the manuscript. TE participated in designing the study,evaluating...

Báo cáo y học: "Does intensive insulin therapy really reduce mortality in critically ill surgical patients? A reanalysis of meta-analytic data." pdf

... IntroductionTwo recent systematic reviews that evaluated intensive insulin therapy (IIT) in critically ill patients grouped the included randomized controlled trials (RCTs) by type of intensive ... deci-sions. In particular, the decision to group trials by type of ICU rather than by type of patient may not be intuitive for clinicians, for whom the important question is whether IIT saves lives in ... trials.Categorizing surgical and medical subgroups by type of patient rather than type of ICUWe considered all trials of IIT included in the two recent systematic reviews [1,2]. Our primary analysis...

Báo cáo y học: "A first city-wide early defibrillation project in a German city: 5-year results of the Bochum against sudden cardiac arrest study" potx

... programme in Bochum, including the precedingtraining and an estimation of the costs of the project in relation to the number of lives saved.MethodsBochum is a city of 380,000 inhabitants in the ... dynamic improvement and enable the incorpo-ration of findings emerging in the course of the project. It involves a combination of the principles of "public access" and "first-responder ... reflects an authentic situation of a sys-tem mainly initiated and supported by public institutions and volunteers and implemented with the support of the local EMS. In addition to the main outcome...

Báo cáo y học: "Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Diseas"

... CAD and 20 pa-tients having normal coronary arteries attending car-diology clinic at Yuzuncu Yil University Hospital. The study was approved by the local ethics committee according to the ... stems from a cohort study of eastern Finnish men, in which high levels of serum ferritin and dietary Fe intake were positively associated with the incidence of myocardial infarction. Ascherio ... vitamins and the prevention of coronary heart disease. Am Fam Physi-cian. 1999; 60: 895-904. 7. Yavuz B, Ertugrul DT, Cil H, et al. Increased Levels of 25 Hy-droxyvitamin D and 1,25-Dihydroxyvitamin...

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