Báo cáo y học: "CpG Immunotherapy in Chenopodium album sensitized mice: The comparison of IFN-gamma, IL-10 and IgE responses in intranasal and subcutaneous administrations" docx
Báo cáo y học: "CpG Immunotherapy in Chenopodium album sensitized mice: The comparison of IFN-gamma, IL-10 and IgE responses in intranasal and subcutaneous administrations" docx
... prevent the inflammatory responses in mouse. In this study we used CpG/Ch.a for immunotherapy of Ch.a-induced asthma and compared the intranasal (I.N) and S.C routes of administration concerning ... Ch.a sensitized mice. This result could indicate the advantage of I.N route of administration in CpG/Ch.a therapy of asthmatic mice.On the other hand, we found the significant increases in IL-10 ... administration of CpG/Ch.a. in sensitized mice.Regarding TH2 responses, our study indicated a decrease in total serum IgE following the CpG immunotherapy. In contrast to Mo JH [17] we and...
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Báo cáo y học: "Passive immunotherapy for influenza A H5N1 virus infection with equine hyperimmune globulin F(ab'''')2 in mice" pdf
... that digestion within 36 h completelyeliminated the high molecular weight material (e g. albu-min and transferrin bands and the intact IgG), and onlyF(ab')2 band (~100 kDa) and very low ... after intranasal challenge with the influenza Guangdong H5N1 virus strainFigure 4Efficacy of passive immunotherapy of influenza H5N1 virus infection by i.p. injection of F(ab')2 at dose of ... Ouyang1 and Xinbing Yu1Address: 1Sun Yat-sen University, Guangzhou 510080, China, 2Kunming General Hospital of Chengdu Military Area, Kunming, 650000, China and 3Haerbin Veterinary...
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Báo cáo y học: " West Sweden Asthma Study: Prevalence trends over the last 18 years argues no recent increase in asthma" pdf
... regarding other respiratory symptoms, whichmay in part be explained by some differences in the ques-tionnaires [32]. The decrease in prevalence of respiratory symptoms in the area of Hisingen in ... the region of West Gothia. The first study, the Gothenburg part of the European Community Respira-tory Health Survey (ECRHS), was performed on the island of Hisingen in the city of Gothenburg. ... true increase in prevalence. In contrast to the decrease in prevalence of respiratorysymptoms, our study demonstrated a clear increase in the prevalence of allergic rhinitis in the area of Hisingen...
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Báo cáo y học: "Bispectral index versus COMFORT score to determine the level of sedation in paediatric intensive care unit patients: a prospective study" docx
... Spies31Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Charité University Hospital Berlin, Berlin, Germany2Professor of Cardiac Surgery, Department of Pediatrics, ... Benjamin Franklin, Charité University Hospital Berlin, Berlin, Germany3Professor of Anesthesiology, Department of Medical Statistics and Clinical Epidemiology, Campus Benjamin Franklin, Charité ... With this in mind, data obtained continuously using nonstimulating methods such as bispectral index (BIS) mayhave benefits in comparison with clinical monitoring of sedation. The aim of this prospectiveobservational...
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Báo cáo y học: "A steady state analysis indicates that negative feedback regulation of PTP1B by Akt elicits bistability in insulin-stimulated GLUT4 translocation" potx
... increasing the concen-tration of proteins that amplify the insulin action and decreasing the concentration of proteins that attenuateinsulin-signaling pathway. This indicates that the bistabil-ity and ... experiments and hypotheses. Ear-lier mathematical modeling studies of insulin signalingpathways have focused on subsystems of the pathway, likeinsulin receptor binding kinetics [20,21], receptor recy-cling ... action of insulin is initiated by binding to the tyrosine kinase recep-tor and its subsequent activation. The activated tyrosinekinase receptor undergoes autophosphorylation and cata-lyzes the phosphorylation...
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Báo cáo y học: " Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study" pptx
... elevated hepcidin and Hb decrease in sep-tic patients. However, the causal relation of the induction of hepcidin by IL-6 and the development of anemia by sustaining elevated hepc idin levels has ... Consider-ing the fact that the lifespan of erythrocytes of approxi-mately 120 days might be shortened due toinflammation and the fact that hepcidin suppresses ery-thropoiesis itself, we hypothesized ... revised the manuscript and participated in the design of the study and was responsiblefor hepcidin measurements. PP conceived of the study, participated in itsdesign and coordination and helped...
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Báo cáo y học: " Using Geographic Information Systems (GIS) to assess the role of the built environment in influencing obesity: a glossary" pptx
... areaunitirrespectiveofwheretheyliveinthatunit ,the amount of time that they spend in the area, and theirability to travel within and beyond the boundary of the administrative unit. GIS has impr oved measurements of accessibility by enabling the ... study design and the redrafting of the paper. All authors read and approved the final version of the final paper.Competing interests The authors declare that they have no competing interests.Received: ... e of the intensity of exposure to fea-tures of the built environment and may be an importantdeterminant of health behaviours as it relates to the accessibility of potentially health promoting...
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Báo cáo Y học: A single charged surface residue modifies the activity of ikitoxin, a beta-type Na+ channel toxin from Parabuthus transvaalicus doc
... Gly23 of birtoxin (Fig. 4). In ikitoxin the presence of Glu23 chargepreceding the a-helix modifies the activity of this toxin in aunique way to result in reduced potency in mice. The C-termini of ... previ-ously for birtoxin [6]. Brie y, the cysteine residues of the peptide were reduced and carboxymethylated by incubating in 6Mguanidine hydrochloride, 0.1MTris/HCl (pH 8.3),1mMEDTA and 20 ... moni-tored continuously up to 24 h, after which the symptomsfaded and the mice completely recovered. Ikitoxin did notshow lethality during the course of the observation period in the range of injected...
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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
... fitness in contexts of differential IL-2 levels in contexts of homeostasis and inflammation. Therefore, the waning of Treg cells, and ensuing breakdown in the self tolerance, could dependon the in ... frequent therapy in the treat-ment of solid tumors, mainly melanoma and renal can-cer. In such cases, high doses of IL-2 are injectedfrequently leading to tumour regression in only about10% of ... understanding of the fundamental role of these cells in the pathophysiology of many human dis-eases. Moreover, we have no reason to assume that the primary immune dysfunction is identical among indivi-duals....
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Báo cáo y học: "Computerized two-lead resting ECG analysis for the detection of coronary artery stenosis" pps
... determine the level of disease or quantifying the patient’s myocardial ischemic burden at the time of the testing. Resting ECG analysis, including that of the 12-lead ECG, typically has significantly ... modeling is used in the analysis of complex systems and the interactions of internal and external environments with those systems. In the case of the heart, analysis is performed on the signals ... provide very high sensitivity and specificity for the prediction of hemodynamically relevant CAD as diagnosed with coronary angiography. In the present study and in the previous study by Weiss...
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