...
Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary
Corresponding address: Andrew E. Czeizel Foundation for the Community Control of Hereditary Diseases, 1148 Budapest, ... characteristics of the
study population, etc. In Hungary the total prevalence of
congenital abnormalities was 66.83 per 1000 informative
offspring in...
... Germline Gene Therapy
An ideal gene transfer system in the context of human germline gene therapy would have the
following features: (a) the ability to deliver transgenes in a highly efficient ... applied to humans. The purpose of this paper is to consider the potential for applying the
available genetic modification (GM) technologies to the goal of...
... the sequences of 1CEV and 1RLA and pasted into the
structural alignment. The alignment was then corrected by
hand. Since the sequences of the two arginases and
agmatinase greately differ in the ... in the case of E. coli
agmatinase, of the loop indicated by the letter a.
Fig. 5. Scheme of the binuclear manganese cluster and the localization...
... J. Biochem. 268) q FEBS 2001
Studies on the nonmevalonate pathway of terpene biosynthesis
The role of 2
C
-methyl-D-erythritol 2,4-cyclodiphosphate in plants
Monika Fellermeier
1
, Maja Raschke
1
, ... (2000) Studies on the nonmevalonate pathway: conversion
of 4-(cytidine 5
0
-diphospho)-2-C-methyl-D-erythritol to its 2-phos-
pho derivative by 4-(cytidi...
... raises the possibility that any one or a
combination of these properties may in uence the binding
of apolipoproteins to lipoprotein particles. The capacity to
fractionate lipid emulsions into relatively ... apolipoprotein E3 and E4 to emulsions (Eur. J. Biochem. 269) 5941
Differences in the binding capacity of human apolipoprotein
E3 and...
... technology has been,
theoretically, to increase the safety and com-
pleteness of surgery in addition to increasing the
confidence of the surgeon. This accounts for the
increasing numbers of health ... state of the art in endoscopic sinus
surgery includes many recent innovations. Prob-
ably the most fundamental change in sinus surgery
has been the adaptation of ri...
... the
synovium, in ligaments especially near their insertions, in bone,
in muscle, and in the outer third of the meniscus in the knee. In
an unusual study in which the lead investigator became the
study subject ... provided
new insights into how OA may be successfully managed.
The symptoms of osteoarthritis: pain and
instability
The pain of OA is activity-rel...
... consequence of the activation of many cell populations
and, ultimately, of the upregulation of proinflammatory cyto-
kines [19,20]. By whichever means they themselves become
activated, they induce ... activity. The degree of disease activity
at the start of a disease-modifying therapy is a
major determinant of the disease activity
attainable in treatment.
Background...
... increased the sen-
sitivity of detection of antibodies in serum against NCII from
Figure 2
Purification of CB peptides of type II collagen (CII)Purification of CB peptides of type II collagen (CII). ... CIICorrelation of antibodies against bovine type II collagen (CII) and
human CII. Scatter plot of the levels of IgG antibodies against human
C...
... responses. Furthermore, immune complexes of ANAs
can drive the production of proinflammatory cytokines, inducing the
‘interferon signature’, and intensifying disease. Together, these
findings point to ... entirety of the immune system. Some of these may
be genetically determined, whereas others arise secondarily
in response to events such as infection. Not surprisingly,
deline...
... or
inhibitors of inflammatory cytokines.
Degeneration of articular cartilage in osteoarthritis:
inflammation
The role played by inflammatory cytokines and mediators
produced by joint tissues in ... hypertrophy and hyperplasia, with
an increased number of lining cells, often accompanied by
infiltration of the sublining tissue with scattered foci of
lymphocytes [68]. Synovitis...
... system and the method to detect the
early stage of degeneration of human articular cartilage. The
signal intensity, considering tissue histology [4] and
estimation of the mechanical property of ... charac-
teristics of human cartilage in vivo is developed, we believe
Letter
Ultrasound has the potential to detect degeneration of articular
cartila...
... recent attention, the
potential benefits of these therapeutics for improving
therapeutic protocols, patient compliance, and broader
administration of immunotherapy is equally attractive. At
the ... moment, the potential benefits of biotechnology in
the field of allergy treatment can only be envisioned, and
whether these benefits will indeed manifest still requires...
... emotionality. They selectively
incorporate scientific findings that support their “major
premise” while shunning or ignoring scientific findings
incongruent with their way of thinking”.
A recent ... In that year Edwin Webb and his colleague s
compiled and pub lished the “Report of the Committee of
Inquiry into Chiropractic, Osteopathy, Homoeopathy and
Naturopathy”, commonly called The...
... DNA replication, they may become distrib-
uted among daughter strands in the same semiconservative
way as newly synthesized DNA [17]. In addition, modifica-
tions such as methylated lysine 4 of ... interaction
was further confirmed by the finding that these RNAs also
co-precipitate with chromatin-bound ASH1, and that the
association of ASH1 with the bxd PRE/TRE is abolished by
removin...