... catheter.Amifostine was infused via the Peripheral DilatationCatheter line intra-aortically and proximally to the occluded segment, 15 min prior to the release of aortaocclusion by deflation of the balloon. ... related to DNA structure and synthe-sis [33]. Indeed, Amifostine induces the DNA- bindingactivity of wild-type p53, with its most important bio-chemical function being the activation of genes involved in ... polymorphonuclearleukocyte and macrophage influx, and) activation of the calcium-activated cysteine protease calpain which ismediating axonal damage in SCI.One of the consequences of mitochondrial dysfunction,COX...