... gastrointestinal adverse events, we included an overallmeasure of gastrointestinal tolerability as well as individualgastrointestinal adverse events of nausea, vomiting, abdominalpain, dyspepsia, ... paracetamol,rofecoxib, and NSAIDs, because each comparator had a dif-ferent mechanism of action from any other. In addition, analysis of celecoxib against all active comparators combined was ... effective, safe, and well tolerated.NSAIDs have provided the mainstay of pain therapy, particu-larly in the early stages of disease, but are often associatedwith clinically relevant adverse events.Common...