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Báo cáo y học: "A simpler method of preprocessing MALDI-TOF MS data for differential biomarker analysis: stem cell and melanoma cancer studies" pptx

Báo cáo y học:

Báo cáo y học: "A simpler method of preprocessing MALDI-TOF MS data for differential biomarker analysis: stem cell and melanoma cancer studies" pptx

... AccessA simpler method of preprocessing MALDI-TOF MS data for differential biomarker analysis: stem cell and melanoma cancer studiesDong L Tong1*, David J Boocock1, Clare Coveney1, Jaimy Saif1, ... Tong et al.: A simpler method of preprocessing MALDI-TOF MS data for differential biomarker analysis: stem cell and melanoma cancer studies. Clinical Proteomics 2011 8:14.Submit your next manuscript ... SELDI MS or LC -MS use, rather than for MALDI-TOF MS use.Consequently, very limited functions of these tools can be used in MALDI-TOF MS data analysis. Thus, we have developed an in-house data preprocessing...
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Báo cáo y học:

Báo cáo y học: " The National Institute of Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for Leicestershire, Northamptonshire and Rutland (LNR): a programme protocol" pdf

... defined by the Canadian Insti-tutes of Health Research as 'the exchange, synthesis, and ethically-sound application of knowledge within a com-plex system of interactions among researchers and ... JB, Kizer KW, Dudley RA: Effect of the transforma-tion of the Veterans Affairs Health Care System on the qual-ity of care. NEJM 2003, 348:2218-2227.12. Yano EM: The role of organizational research ... Steiner6, Martin Williams7 and Paul Sinfield7Address: 1Department of Health Sciences, University of Leicester, Leicester, UK, 2School of Psychology, University of Leicester, Leicester,...
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Báo cáo y học: "A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens" pptx

... Dublin 2, Ireland, 2Institute of Immunology & Department of Biology, National University of Ireland, Maynooth, Co. Kildare, Ireland and 3Centre for Clinical Vaccinology and Tropical Medicine, ... immuno-stimulatoryassays. ST and DD contributed to the design and supervi-sion of the immuno-stimulatory assays. TCJ and UB con-ceived and designed the methods for the isolation of thepeptide mimics of ... IL-12.Therefore, we can conclude that (a) the activation of lym-phocytes must be dependent upon the uptake of the pep-tide by iDCs and its representation to lymphocytes and (b) it is not the result of...
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Báo cáo y học: " A rapid method to screen putative mRNA targets of any known microRNA" pdf

... argetsby Bioinformatics. Hybrid-PCR has much more flexibil-ityandcanbeusedtoidentifytargetmRNAsforamiRNA from any kind of cells at different developmentstages or from different tissues. Hybrid-PCR ... Expr ession of mature miR-UL112-1was measured by TaqMan®microRNA assays on 7300Fast Real-Time PCR System (Applied Biosystems) (data not shown).Luciferase reporter assaysAssays were conducted ... products of hybrid-PCR werepurified, cloned into T-vector and sequenced. Fifty-foursequences were obtained successfully in our study.Hybrid-primer sequ ences and polyA structure were con-firmed for...
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Báo cáo y học: "A statistical method for predicting splice variants between two groups of samples using GeneChip® expression array data" pps

... decreased for a dataset that containedonly three tissue types compared to a dataset that con-sisted of ten tissue types. The robustness of their method depended on the number of the tissue types ... gene expression array data with GeneChip® technology. Our method employs the extensive repositories of gene expression array data available and generatesalternative splicing hypotheses, which ... GeneChip®expression array data on ten tissue types [5]. For eachprobe, they calculated the difference in the fold changebetween each tissue type and the average of the remainingtissue types for the corresponding...
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Báo cáo y học: "A simplified method for power-law modelling of metabolic pathways from time-course data and steady-state flux profiles" pps

... novel method involving power-law modelling of metabolic pathways from the Jacobian of the targetedsystem and the steady-state flux profiles by linearization of S-systems.Results: The results of ... for representing enzyme-catalyzed reactions, known as Biochemical Systems The-ory, is an effective approach for understanding metabolicsystems [2,3]. Generalized Mass Action (GMA) and S-sys-tems ... of large-scale S-system models of metabolic pathways, realizing a practical application of reverse engineering of dynamic simulation models from the Jacobian of the targeted system and steady-state...
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Báo cáo y học: "A severe coarctation of aorta in a 52-year-old male: a case report"

... discomfort, fatigue and dyspnea in his fifth decade of life. Conflict of interest None declared. References 1. Grech V. Diagnostic and surgical trends, and epidemiology of coarctation of the ... compensatory mechanisms in a 76-year-old man with a coarctation of the aorta. Cardiology 1999, 92:284-286. 8. Bauer M, Alexi-Meskishvili V, Bauer U. Benefits of surgical repair of coarctation of the ... Diagnosis is usually based on clinical suspicion and physical findings3. The latter include blood pressure differenc e between the upper and lower extremities, pulse delay and systolic murmur...
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Báo cáo y học:

Báo cáo y học: "A pilot study of rizatriptan and visually-induced motion sickness in migraineu"

... closed. Severity of ab-normalities in each category are rated by the subject and technician, with a range of scores for nausea of 0 to 16, for skin color of 0 to 8, for cold sweating of 0 to 8, ... Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, USA 2. Department of Anesthesiology & Critical Care Medicine, University of Pittsburgh School of Medicine, ... Limitations of this study include the small number of subjects and the inclusion of only females. The gender inequality may have been less important given the finding by Park and Hu 39 that...
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Báo cáo y học: "A Randomized Study of Epithelial Ovarian Cancer: Is Chemotherapy Useful after Complete Remission"

... adenocarcinoma, one case of small cell lung cancer, one case of hypernephroma, and one case of head and neck cancer. Six of these patients were in the nihil arm. Only one patient (head and neck cancer) was ... Biochemistry at New York University, is presently in his final year of medical studies at the University of Padua and will pursue resident training in Oncology. His current interests include cancer cell ... it is limited by the lack of stratification by stage, and by previous type of chemotherapy (table 2) as well as by the limited number of patients randomized (122 pts). The lack of stratification...
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Báo cáo Y học: A novel gain-of-function mutation of the integrin a2 VWFA domain docx

Báo cáo Y học: A novel gain-of-function mutation of the integrin a2 VWFA domain docx

... affecting the way i n whichthe t ertiary complex of VWFA domain, c ation and ligandare formed. This was accomplished without any a lterationin the specificity of t he interaction. The differential ... withwild-type a2. (A) JA203 binds with lower affinity to a2-E318 W (s)than to wild-type a2 VWFA domain (d); (B) B inding of JA202 isidentical for a2-E318W ( s) and wild-type (d), and is shown for comparison. ... shown by unaltered binding of a range of antibodies to the mutant domain compared to t he wild-type.Residue E318 differs substantially in its position betweenthe open and closed forms of a2....
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