Báo cáo y học: " Interactions Between Estrogen- and Ah-Receptor Signalling Pathways in Primary Culture of Salmon Hepatocytes Exposed to Nonylphenol and 3,3'''''''',4,4''''''''-Tetrachlorobiphenyl (Congener 77)" ppsx
... expression patterns of ERα (A), ERβ (B), Vtg (C) and Zr-protein (D) mRNA in primary cul-
ture of salmon hepatocytes exposed to 5 μM NP and 1 μM PCB-77, both singly and in combination. Hepatocytes
were ... 1 of 14
(page number not for citation purposes)
Comparative Hepatology
Open Access
Research
Interactions Between Estrogen- and Ah-Receptor Signalling...
... orientation, and specificity of this
domain, with residues Tyr91 and Tyr137 forming
interaction pocket 1; Tyr93, Tyr137 and Trp119 form-
ing pocket 2, and the valley between n-Src and RT
loops included by ... the interaction is highly dependent
on phosphorylation performed by the Src family kinase Fyn, which docks
onto PAG using a dual-domain binding mode involving both SH3- and...
... is a potent proinflammatory cytokine related to the
pathogenesis of inflammatory diseases such as RA and IBDs
[5,6,11]. The precise mechanism of TNFα induction in the
inflammatory diseases, however, ... proinflamma-
tory cytokines participate in promoting the inflammation of the
joints. TNFα facilitates arthritis and the destruction of bone [1-
4]. TNFα is secreted by severa...
... analysis of
gene–environment interactions to date is hypothesis
driven. The difficulties in quantifying and characterizing
environmental risk factors for atopy (including onset and
length of period ... pheno-
copy, incomplete penetrance, and genetic heterogeneity
[9]. The complexity of the genetics of asthma and other
atopy-associated phenotypes is reflected by an increa...
... diversity in brain and blood
Previous studies indicated both Vpr-encoding transcripts
and proteins were present in the brains of HIV-infected
persons [20,33], chiefly in cells of monocytoid lineage in
keeping ... (without cytosine arabinoside) and
ready for HIV transfection or infection in two days.
Neuronal toxicity assay
Neurotoxicity assays were performed by methods
des...
... [14,68]. In support of these findings, a
recent study found that SIV Nef not only augments the
incorporation of many retroviral glycoproteins onto Gag
of SIV by increasing their co-localization in ... proof for interactions between viral proteins and
the ESCRT machinery [27,33]. We also confirmed the spe-
cificity of binding for AIP1 by deletions and mutations of
the con...
... ethynylestradiol acted as a non-competitive
inhibitor of CYP1A activity and as an uncompetitive inhibitor of CYP3A activity.
Conclusions: Ketoconazole, nonylphenol and ethynylestradiol all interacted ... effects of the model imida-
zole ketoconazole and of two types of xenoestrogens
(nonylphenol and ethynylestradiol), as well as of a mixed
exposure to ketoconazole a...
... arthritis. It remains to be determined whether
circulating IL-1F8 can contribute to joint inflammation in
rheumatoid arthritis.
Introduction
Until recently, the IL-1 family of cytokines included four ... Internal Medicine, University Hospital and Department of Pathology and Immunology, University of Geneva
School of Medicine, Geneva, Switzerland
2
Division of Genomic Medi...
... The cost and availa bility of
medicines and providers is a factor driving the use of
alternative providers, including self-treatment using eth-
noveterinary practices and purchasing medicines from
human ... and Township Veterinary Stations of Gongshan County
for helping us to identify the Nu communities to interview. I wish thank Dr.
Ronnie Vernooy and Dr. Wilkes Andreas,...