Báo cáo y học: "TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells" potx
Báo cáo y học: "TGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells" potx
... 1 of 12(page number not for citation purposes)Comparative HepatologyOpen AccessResearchTGF-β dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate ... conse-quence of the aerobic lifestyle caused by the photosyn-thetic activity of herbal organisms, which in turn dependson the capability of oxygen reduction occurring during respiration. Reactive oxygen ... AB: Source of oxygen free radicals produced by rat hepatocytes during postanoxicreoxygenation. Biochim Biophys Acta 1995, 1268:249-254.3. Adachi T, Togashi H, Suzuki A, Kasai S, Ito J, Sugahara...
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Tài liệu Báo cáo Y học: Characterization and regulation of yeast Ca2+-dependent phosphatidylethanolamine-phospholipase D activity docx
... it may, the ability of PtdEtn-PLD to bind to immobilized PtdEtn may facilitate the future use of aPtdEtn-affinity matrix for purification of PtdEtn-PLD byphospholipid-affinity chromatography.In ... regardless of whetherthe yeast cultures are initiated in YPD, YPG or YPA.Interestingly, further analysis has shown that PtdEtn-PLDactivity is also stimulated upon exit of yeast cells fromstationary ... Size-exclusion chromatography of membrane (A), cytosolic (B)and partially purified cytosolic (C) PtdEtn-PLD activities on Superdex-75. Salt-extracted membrane, crude cytosolic, and cytosolic PtdEtn-PLD...
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Báo cáo y học: "DHEA-dependent and organ-specific regulation of TNF-α mRNA expression in a murine polymicrobial sepsis and trauma model" pps
... type [14,18,28]. It has already beenobserved by several authors that secretion of a number of cytokines was at least partly restored by DHEA treatment[14,18,21,22,28]. Our results are partly ... normalizes mRNA cytokine levels timedependently, with regard to the immunologic tissue context.As initially mentioned, pro- and anti-inflammatory cytokinesinfluence the expression levels of each other. ... be interfered by IGF-I, and thata variety of cytokines and growth factors play a role in the mod-ulation of hormone secretion [37,38]. This could result in time-dependently varying reactions...
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Báo cáo y học: "HLA-DR regulation and the influence of GM-CSF on transcription, surface expression and shedding
... capability of monocytes and macrophages to phagocytose invading pathogens [16]. GM-CSF treatment of septic patients’ lymphocytes ex vivo has been shown to restore function in anergic monocytes ... in plasma and synovial fluid in hyperinflammatory states [9] and in vitro experiments have shown that the inflammatory cytokine IFN-γ induced shedding of HLA-DR by human monocytes [10]. However ... percentage of cells expressing HLA-DR on monocytes and the density of HLA-DR was measured. Immuno-fluorescent microscopy of HLA-DR in PBMC Cytospins of PBMC obtained from healthy controls...
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Báo cáo y học: "Allele dependent silencing of COL1A2 using small interfering RNAs"
... previously by Millington-Ward (14) who reported allele-preferential silencing of COL1A1 in COS7 cells and in primary human mesenchymal progenitor cells. The results reported by Milling-ton-Ward ... can be used to silence predominately one allele of COL1A2 in primary bone cells. The next step is to scan the full range of polymorphisms in the COL1A2 and COL1A1 and to design highly allele-specific ... heavily dependent on the base composition of target sites in mRNA as well as on the siRNA sequences themselves. It will be necessary to analyze allele specificity and off-target effects of a...
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Tài liệu Báo cáo Y học: Presence and regulation of the endocannabinoid system in human dendritic cells potx
... 2-arachidonoylglycerol (2-AG), the cannabinoid CB1and CB2receptors, and one of the enzymes mostlyresponsible for endocannabinoid hydrolysis, the fatty acidamide hydrolase (FAAH). By using a very ... Uni-versity of Rome-Tor Vergata, Italy), was elicited against theconserved FAAH sequence VGYYETDNYTMPSPAMR[26].Isolation of human monocytes and differentiationinto dendritic cells Dendritic cells ... reduction of the cytolytic activity of naturalkiller cells and of antigen presentation was also observed,again in vitro [9].The endocannabinoid system, comprising membranereceptors for THC,...
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Báo cáo Y học: Autophosphorylation-dependent inactivation of plant chimeric calcium/calmodulin-dependent protein kinase docx
... Ca2+-stimulated autophosphory-lation of CCaMK results in time -dependent loss of enzymeactivity. This time -dependent loss of activity or self-inacti-vation due to autophosphorylation is also dependent ... chimericcalcium/calmodulin -dependent protein kinaseP. V. Sathyanarayanan and B. W. Poovaiah1Laboratory of Plant Molecular Biology and Physiology, Department of Horticulture, Washington State University,Pullman, ... at80 kV.RESULTSAutophosphorylation and kinase activity of CCaMKAutophosphorylation of CCaMK was associated with atime dependent loss of the Ca2+/CaM -dependent enzymeactivity at pH 6.5, 7.5...
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Báo cáo Y học: Concentration-dependent reversible activation-inhibition of human butyrylcholinesterase by tetraethylammonium ion pptx
... reversibleinhibitors of cholinesterases. However, at concentrationsaround 10 mM, they have been found to activate thehydrolysis of positively charged substrates, catalyzed bywild-type human butyrylcholinesterase ... curve analysis of BTC hydrolysisby recombinant wild-type human BuChE, by four selectedmutants (Y3 32A/D70G, Y3 32D/D7 0Y, W82A, A32 8Y) and by commercial horse serum BuChE in the presence of TEA. ... secondly, enhance thestability of the acylated enzyme.In order to find out whether the extremely poor activity of the W82A mutant is due to low affinity for the substrateand/or to the slow acylation-deacylation,...
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Báo cáo y học: " TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7" pps
... fact that notall cells in the synovial lining will be targeted. By optimizingthis, we might be able to target every single one of the synoviallining cells and thereby fully block the TGF-β-induced ... cartilage of the OA model. TGFβ-induced synovialfibrosis was strongly diminished by simultaneous synovialoverexpression of Smad7 in the synovial lining. Of great interest,overexpression of Smad7 ... fashion, we could potentially target themesenchymal stem cells that eventually form the osteophytesafter TGF-β exposure. This could be an option when key play-ers of osteophyte formation are identified...
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Báo cáo y học: "Expression and regulation of CCL18 in synovial fluid neutrophils of patients with rheumatoid arthritis" potx
... mononuclear cells was approximately1:10.Flow cytometryThe purity of PMN was routinely analyzed by flow cytometrywith FACSCalibur (BD Biosciences, Heidelberg, Germany). Inbrief, to prevent ... Man-nheim, Germany) and labeled by use of the Dyomics DY-648-S-NHS/DY-548-S-NHS dye system (Dyomics, Jena, Ger-many). Dyomics DY-648-S-NHS-labeled cDNA was cohybrid-ized with DY-548-S-NHS-labeled ... 3Microarray analysis of chemokine receptor gene expression in synovial fluid polymorphonuclear neutrophilsMicroarray analysis of chemokine receptor gene expression in synovial fluid polymorphonuclear...
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