Báo cáo y học: "Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease" potx
Báo cáo y học: "Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease" potx
... by macrophages and other cell types [99,100]. Therefore, one of the functions of MAP kinase signaling pathway may beto regulate the levels of cytokines or interleukines, therebycontrolling cell mitosis in ... AccessReviewAdvances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and diseaseEric ... protein, and the fatty acid translocase [53]. Recently, the idea of a link between PPARγ and the insulin signalinghas been reinforced by the finding that the c-Cbl-associat-ed protein, a signaling...
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Báo cáo y học: "T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFκB: implications for rheumatoid arthritis" docx
... Elutriation was performed in culture medium containing1% heat-inactivated FCS. The monocyte purity and lym-phocyte purity were assessed by flow cytometry, and fractionswere typically >80% and 90% ... lymphocytes were then added to the wells to give a final T cell:monocyte ratio of 7:1 and a finalassay volume of 200 μl. Cultures containing monocytes alone and cultures containing lymphocytes ... translocation and DNA bindinginduced by LPS.We then examined whether IκBα overexpression inhibitsmonocyte chemokine production induced by Ttcr cells. Wefound that AdIκBα inhibits the production of CC...
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Báo cáo y học: "Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages" pdf
... group of ROS (direct effect) or stim-ulating the synthesis of the cellular GSH levels and therefore protecting the cells against oxidants (indirecteffect) by modulating the redox signaling pathways[22,23]. ... study, and partici-pated in the design of the study and performed immu-noassays, FACS analysis, statistical analysis, and wrote the first draft and final version of the manuscript. KK, AK IR and ... in designing the experiments and took part in critical revision of the manuscript. FN partic-ipated in the design and coordination of the study. GFconceived of the study, and participated in...
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Báo cáo y học: "Is it time for implementation of tight glycaemia control by intensive insulin therapy in every ICU" pdf
... tight glycaemia control by intensive insulintherapy (IIT) confirmed in medical intensive care unit patients the decrease in hospital mortality reported by the same team in the firstIIT trial in ... (ICU and 28-day mortality, requirement for dialysis, incidence of bacteraemia, requirement for prolongedantibiotic therapy, incidence of hyperbilirubinaemia and ‘hyper-inflammation’) were not influenced ... mortality was.As already underlined [7], the mortality rate of the medicalpatients was high. Other local factors could also haveinfluenced the results, thereby questioning the applicability of the...
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Báo cáo y học: "Infra-red thermometry: the reliability of tympanic and temporal artery readings for predicting brain temperature after severe traumatic brain injur" pot
... temporal arteryreadings during local (forehead) sweating. This finding mightbe explained by the fact that during the 'sweep' across the forehead (followed by the 'behind the ear' ... captures infra-red heat energy from the skin overlying the course of the temporal artery [11]. The tech-nique is quick; the instrument is easy to clean and is relativelyinexpensive. The aim of the ... 3ResearchInfra-red thermometry: the reliability of tympanic and temporal artery readings for predicting brain temperature after severe traumatic brain injuryDanielle Kirk1, Timothy Rainey1, Andy...
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Báo cáo y học: "Baseline values from the electrocardiograms of children and adolescents with ADHD" docx
... offset of the T wave, then the offset of the QT interval was defined as the intersection of the tan-gent to the midpoint of the downslope of the T wave and the isoelectric baseline. Cardiologists ... [11].We therefore used all 3 correction methods for the QTinterval. In the Bazett method, the QT interval was divided by the square root of the R-R interval (defined as the length of the entire ... cycle). In the Fridericia for- mula, the QT interval was divided by the cube root of the R-R interval [10]. For the data-derived correction factor,we used the value that was determined in the...
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Báo cáo y học: "Users' guides to the medical literature: how to use an article about mortality in a humanitarian emergency"
... keep in mind when reading amortality survey to determine the validity of the study and the applicability of the findings to theirsettings.Public health scenarioYou are a physician working for ... into two strata along the 2001 line of military con-trol: an east stratum of territory formerly held by rebelgroups and a west stratum of territory formerly held by government forces. Within ... benchmark the severity of the crisis, by referring the study's mortality rate to internationally agreed-uponthresholds for defining states of emergency (Table 1).While several definitions for...
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Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx
... drafting and editing of the manuscript, and preparation of the figures. SMB was involved with the design and coordination of the study. AL was involved with the design and coordination of the ... extracellular space determined that many of the protein products of these genes were involved in a variety of activities, including chemokine/cytokine activity – includingmacrophage Csf-1 – and various protease ... DMSO-soluble inhibitors, suchas U0124, U0126 and PD153035, reduced TNF -activated NFB-DNA binding activity. The regulation of NFB-DNAbinding in primary cells can therefore be explained by the non-specific...
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Báo cáo y học: " An association between the acute phase response and patterns of antigen induced T cell proliferation in juvenile idiopathic arthritis" ppt
... may assist in T cell retention within the mucosal site [28,29]. The results of our studiessupport a similar process of ‘integrin switching’ in the joint.Our findings are in agreement with the ... www.millennium.com) for the kind gift of the Act-1 anti-body. We are grateful to Professor Mike Salmon and Professor ChrisBuckley for critical reading of the manuscript. We acknowledge the financial support of ... of Rheumatology, Division of Immunity and Infection, University of Birmingham, Birmingham, UK2Current address: MRC Human Immunology Unit, Institute of Molecular Medicine, Oxford, UK3Birmingham...
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