Báo cáo y học: "Bench-to-bedside review: Metabolism and nutrition" ppsx
Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... of hyperoxia (relativelyearly events). Following 24 hours of hyperoxia, however,NF-κB activation and increased levels of TNF-α mRNA werepresent in pulmonary lymphocytes. By 48 hours of hyperoxia,the ... activation. Reactive oxygen species (ROS) are keycomponents of the pathways leading to the activation of NF-κB, whose binding activity is obliterated by N-acetyl-L-cysteine (NAC) and pyrrolidinedithiocarbamate ... significantly affectingits phosphorylation.Anti-inflammatory cytokine-mediated oxidant injuryAnother anti-inflammatory cytokine that is involved as a reg-ulatory element in lung injury is IL-11....
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... by hypoxia and bycytokines. To identify the cellular mechanisms in control oftubular VEGF production, the effects of hypoxia and IL-1β onVEGF mRNA levels, on VEGF secretion and on activity ... injury, ischemia-reperfusion and transplantation, compromised host defense and inflammatory stimuli, and hypoxemia and the crucial role of hypoxia-inducible factor in mediating lunginjury. Changes ... transcription in physiology and pathophysiology. Reactive oxygen species and reactive nitrogen species serve as signalingmessengers for the evolution and perpetuation of the inflammatory process that...
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Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology" doc
... [8–12]. These supraphysiologic levels causeReviewScience Review: Vasopressin and the cardiovascular systempart 1 – receptor physiologyCheryl L Holmes1, Donald W Landry2 and John T Granton31Staff ... University, New York, New York, USA3Assistant Professor of Medicine, Faculty of Medicine, and Program Director, Critical Care Medicine, University of Toronto, and Consultant inPulmonary and Critical ... which binds toall types of V1R and V2R, certain OTRs, and neurophysins.When selective V1R and V2R radioligands with in vitro auto-radiography were used to study V1R and V2R binding...
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Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 2 – clinical physiology" pps
... phosphoinositidehydrolysis and intracellular calcium mobilization [49]. Adenylylcyclases present a focal point for signal integration in vascu-lar smooth muscle, and type III adenylyl cyclase has ... activates a kinase, which phosphorylates theregulatory light chain of myosin. Phosphorylated myosin acti-vates myosin ATPase by actin and the cycling of myosincross-bridges along actin filaments, ... vasodilatory shock states by bluntingthe increase in cGMP that is induced by NO [28] and ANP[29], and by decreasing the synthesis of inducible nitric oxidesynthase (NOS) that is stimulated by lipopolysaccharide...
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Báo cáo y học: "Clinical review: Vasopressin and terlipressin in septic shock patient" pps
... Oz MC, Landry DW: Vasopressin deficiency and pressorhypersensitivity in hemodynamically unstable organ donors.Circulation 1999, Suppl:II244-II246.15. Tsuneyoshi I, Yamada H, Kakihana Y, Nakamura ... effect on oxygen metabolism (oxygen consumption being measured independent fromoxygen delivery) and the oxygen delivery–consumptionrelationship; gastric mucosal perfusion and splanchnic and hepatic ... index and oxygen delivery. Oxygenconsumption decreased whereas oxygen extractionincreased. These modifications may carry a risk for tissuehypoxia, expecially in septic states in which oxygen...
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Báo cáo y học: "clinical review: Devices and drugs for cardiopulmonary resuscitation – opportunities and restraints" pot
... early response by bystanders who initiateCPR or by minimally trained rescuers, including fire and police personnel, and in which there is early response by aneffective professional emergency ... ability of lay rescuers to identify cardiac arrestpromptly, the availability of additional measurements, and expanded intelligence provided by expanded AEDs with which tomore effectively prompt ... monophasic waveforms and allow lowerenergy defibrillation, which minimizes myocardial injury and the severity of the newly identified condition ‘post-resuscitation myocardial dysfunction’ [13,14].Postresuscitation...
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Báo cáo y học: " Clinical review: Timing and dose of continuous renal replacement therapy in acute kidney injury" ppsx
... at 14 days and 28 days in thisgroup (0.75 and 0.59, respectively) were slightly lower thanin the ‘early’ (BUN ≤ 76 mg/dl) group (0.8 and 0.65,respectively). After adjustment for age and clinical ... stable and eitherCVVHDF or sustained low-efficiency dialysis (SLED) whenthey were hemodynamically unstable. In the intensive therapyarm, IHD and SLED were provided six-times per week and CVVHDF ... multi-centre randomised trial. Lancet 2006, 368:379-385.18. Kellum J, Palevsky PM: Renal support in acute kidney injury.Lancet 2006, 368:344-345.19. Palevsky PM: Dialysis modality and dosing strategy...
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Báo cáo y học: "Clinical review: RIFLE and AKIN – time for reappraisal" pdf
... reanalysis ofthe Australia and New Zealand Intensive Care Societydatabase [16], which compared RIFLE and AKIN on the firstICU day only. Estimates of prevalence and crude mortalitywere very similar ... understand and apply in a variety of clinical and research settings. In recentyears, the use of the consensus definitions of AKI (RIFLE and AKIN) in the literature has increased substantially. Thisincrease ... classifications for acute kidney injury. Risk–Injury–Failure–Loss–Endstage renal disease (RIFLE) and Acute Kidney Injury Network(AKIN) classifications for acute kidney injury (adapted from [6,7])....
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Báo cáo y học: "Stem cells, inflammation and allergy" ppsx
... growthfactors and cytokines. For example, CXCR4/CXCL12, ageneral inflammatory chemokine receptor and chemok-ine ligand, is the only known chemokine receptorexpressed by HSCs and plays an instrumental ... circulation[10,11]. Sim-ilarly, the inflammatory homing selectin ligand, PSGL-1 and its endothelial cell receptors P- and E-selectin, are alsoknown to play a key role in homing and adhesion of HSCsto ... ofTSLP and IL-33, they produced a variety of cytokinesincluding IL-5, IL-13 and GM-CSF. These three mediatorsare well known to recruit and promote chronic inflamma-tion in allergy and asthma....
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Báo cáo y học: "Proteomics gets faster and smarter" ppsx
... protein microarrays. Crisdos Remedios (Institute for Biomedical Research,University of Sydney, Australia) presented an antibodyarray technique that could reportedly identify a variety ofdiseases, ... followedby lectin-based two-dimensional profiling to analyze bothserum proteins and glycoproteins. The lectin-basedprofiling allows the selection of glycoproteins by capture ofthe glycan side ... proteolytic peptide analyzed.A relatively new development in proteomics is the use ofmass spectrometry for imaging. Graham Cooks (PurdueUniversity, West Lafayette, USA) spoke eloquently abouthis...
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