... exertion and is accompanied by impairedmemory and concentration, unrefreshing sleep, muscle and joint pain, and other defining symptoms [2-4]. The pathophysiology of CFS rema ins inchoate; there ... cure, and guides the evaluation of clinical and community interventions designed toreduce the burden of disease.Methods: This research estimated direct and indirect costs of CFS and the impact ... JML and CJS contributed to the primary analyses. SCR, CJS, AJ and DJB wereinvolved in the analysis plan and interpretation of the data. SK collaboratedwith others in generating clinic sampling...