Báo cáo y học: "Burden of disease and costs of aneurysmal subarachnoid haemorrhage (aSAH) in the United Kingdom" ppsx
Báo cáo y học: " Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung" docx
... 1 day 3 day 7 day 14 day 21 day 0 1 2 3 4 5 1 day 3 day 7 day 14 day 21 day 0 1 2 3 4 5 1 day 3 day 7 day 14 day 21 day 0 1 2 3 4 5 1 day 3 day 7 day 14 day 21 day 0 ... recombinant PlGF protein. Pre-incubation of the PlGF antibody with recombinant PlGF protein (R&D, UK) successfullyblocked staining of the tissue therefore indicating that the staining observed ... produced by VEGFA and the interactions of these ligands with VEGFA.Representative images of normoxic wound healingassays in the presence of varying concentrations of recombinant PlGF protein (panels...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... IR. Results of each values were expressed as the following ratio: intensity of WD cDNA/intensity of competitor and then divided by intensity of amplified actin cDNA. PC, the result of competitive ... (underlined basesdenote the functional core of the MREs and the Sp1 bindingelement, and the mutated bases are indicated by italictype).Western blot analysis The MREa-binding proteins purified ... determine whether the MREa–protein complex displays sequence specificity. Binding of the HepG2 nuclear proteins to MREa was inhibited by the addition of a molar excess of unlabelled MREa to the binding...
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Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf
... similar binding proper-ties and in vitro activities to the BLyS and APRIL homo-trimers, and may be present in sera in similar amounts toAPRIL and BLyS, we postulate that they may likely playsimilar ... of assay buffer. Wells werethen resuspended in 100 μl of assay buffer and analyzedby using a Luminex 100 mac hine (Luminex Corporation,Austin, TX, USA). The total assay time was 2 hours. The assayhadabroadrange(~100pg/mlto25ng/ml)withan ... shown). The inhibition of BLyS, APRIL, and the heterotrimersby atacicept is consistent with the observed effects of atacicept and/ or murine TACI-Ig in preclinical and clin-ical studies. In mice and...
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Báo cáo Y học: Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4 pdf
... feature in mucin, contained only by the mousesubmandibular small mucin [26]. The consensus sequence of the Muc4 tandem repeat isvery close to that of SMC. Nevertheless, the tandem repeatdomain of ... transcript of apredicted size of 13 kb. Both human MUC4 and mouseMuc4 genes are virtually identical in terms of the class of introns, the exon number and size of exons. The sizes of the 24 mouse introns ... Wille-brand Factor (vWF), is rich in cysteine residues and mayparticipate in intermolecular disulfide bonds (reviewed in [30]). Nevertheless, the cysteine residues conserved between the vWF and the...
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Báo cáo Y học: Domain organization, folding and stability of bacteriophage T4 fibritin, a segmented coiled-coil protein docx
... alsoas a chaperone and help the proximal and distal parts of the long tail fibers to join correctly by increasing the effectivetarget sizes and thereby increasing the rates of otherwiseslow diffusion–limited ... a helicity at this temperature and changes in the magnitude of the accompanying enthalpy. The ratio o f the van’t Hoff enthalpy to calorimetric enthalpy of 0.39indicates that the nine putative ... the unfolding and reversible refolding of the nine segments therefore occurs in a s ingle step. The s ingularity of the coiled-coil transition, midpointtemperature and peak sharpness are maintained...
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Báo cáo Y học: Isolation, enzymatic properties, and mode of action of an exo-1,3-b-glucanase from Trichoderma viride doc
... affinities and number of subsites in the active center of the enzyme.According to this theory the kinetic parameters can beexpressed in a unified way in terms of subsite affinities Ai of m subsites and ... enzyme exclusivelydisplays exo-activity in the hydrolysis of 1,3-b-oligogluco-sides, the subsite theory of Hiromi [46,47] was employed forconstruction of a subsite map for the estimation of ... rate constant Kint.Accordingly, the substrate binding affinity becomes the sum of the affinities for glucose residues of the substrateaccessible for binding; the distinction of Vmax(kcat)...
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Báo cáo y học: " Etiological explanation, treatability and preventability of childhood autism: a survey of Nigerian healthcare workers'''' opinion" potx
... were mostly diplomas in general and psychiatric nursing, and they had been working in theirvarious areas of specialty for at least 1 year. The study wasa point survey of opinions of healthcare ... insult to the developingbrain, either as a result of maternal infection, intrauterineinfection or physical trauma to the brain from delivery orbirth complications, and also the theory of supernaturalcauses ... explain or specify what they meant. The second part of the questionnaire dealt with the opin-ion of the healthcare workers on treatability and prevent-ability of childhood autism. It contained the...
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Báo cáo y học: "Residual sleep disturbance and risk of relapse during the continuation/maintenance phase treatment of major depressive disorder with the selective serotonin reuptake inhibitor fluoxetine" docx
... entryinto the study.Residual sleep disturbance measure The Hamilton Depression Rating Scale (HDRS) [31]administered during the randomization visit (baselinevisit of the continuation and maintenance ... monthly for the duration of the 52-week trial.By convention, the first 6 months of this period wereconsidered the continuation phase, and the remainder, the maintenance phase. Identical fluoxetine ... 18 to 65 years of age, with current MDDdefinedusingDSM-IVcriteriawererecruitedatoneoftwo sites: either the New York State Psychiatric Institute in New York City, NY, USA (n = 372) or the DepressionClinical...
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Báo cáo y học: "Predicting hospital admission and discharge with symptom or function scores in patients with schizophrenia: pooled analysis of a clinical trial extension" doc
... contributedto the design of the analysis, interpretation of the data, decision to publish,writing/editing of the text, and final approval of the manuscript. LM contrib-uted to design of the analysis, ... used in other studies, and they are derived directly from the scoring of the instru-ment. Scores above 71 generally represent patients whohave 'mild' ratings in the majority of areas, ... If the sametools are used in the inpatient setting, they may help toidentify which patients are ready for discharge. As experi-ence is gained using symptom and functioning instru-ments, their...
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Báo cáo y học: "Prevalence, clinical relevance and characterization of circulating cytotoxic CD4+CD28– T cells in ankylosing spondylitis" ppt
... cellpopulation in the healthy control individuals tested.Intracellular staining for perforin and IFN-γ was performed in activated cells to determine the number of cytokine pro-ducing cells. Production of ... CD4+CD28–NK T cells initiating and sustaining immune responses, and providing a linkbetween the adaptive and the innate immune systems,may hold true for AS disease. Competing interestsNot declared.Acknowledgements The ... fraction of sub-diploid cells in CD4+cells after staining of DNA using7-aminoactinomycin D. Three days after the last addition of recombinant human IL-2, 16.2 ± 5.9% of the CD4+CD28+but only...
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