Báo cáo y học: "Bench-to-bedside review: The value of cardiac biomarkers in the intensive care patient" pdf

... between the biomarkers and the severity of the disease, the provision of prognosis, and the ease of performing the test. The use of cardiac biomarkers in the ICU continues to evolvewith new findings. ... originally thought. In the intensive care setting, it is important for the user to understand the degree of specificity of these biomarkers and that the interpretation of the results should always ... biomarkers in the intensive care setting isgaining increasing popularity. There are several reasons for thisincrease: there is now the facility for point -of- care biomarkermeasurement providing a rapid...

Báo cáo y học: "Clinical review: Prognostic value of magnetic resonance imaging in acute brain injury and coma" pot

... differences in severity of brain oedema and in associated hypoxia and herniation,thereby introducing bias into the interpretation of the results.MRS findings vary greatly according to time since TBI. ... Normal in the thalamus and in the in the thalamus and in the of hypersignals found basal ganglia basal ganglia previouslyT2 Hypersignals in the cortex, Hypersignals in the cortex, Hypersignals of ... may be moresensitive for detecting mild hypoxic/anoxic injury within the first few hours, and the hypersignal may occur first in the cerebral cortex and later in the basal ganglia. During the...

Báo cáo y học: " Clinical and economic ramifications of switching antipsychotics in the treatment of schizophreniab" pptx

... defined as having switched medications ifthey discontinued the medication to which they were ini-tially randomized at any time during the study and initi-ated therapy with a different antipsychotic ... antipsychotic within 14 days of discontinuation of the initial therapy. Data on the occurrence of acute -care service use, the time to the use of such services, and total -care and acute -care service ... any crisis event at baseline.bRate = number of days with each service divided by the total number of days in the study.cRate = number of admissions divided by the total number of days of...

Báo cáo y học: " Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium" doc

... 11:150http://respiratory-research.com/content/11/1/150Page 14 of 15 The data demonstrate there is expression of genes for acomplete GABAergic system in the airway epithelium.Interestingly, the expression of GAD67 was markedlymodified by smoking, ... expression only of GAD67, a genecontrolling the synthesis of GABA [2]. A strikingincrease in gene expression levels of GAD67 wasobserved in the large and small airway epithelium of healthy smokers ... only in the brain, but also in other organs, including liver,kidney,pancreas,testis,oviduct, adrenal, and lung [3,4].GABAergic System in the Lung In the lung, immunohistochemistry studies of the...

Báo cáo y học: " Clinical and demographic features of pediatric burns in the eastern provinces of Turkey" pdf

... tandir injuries. In their series, most of the burn victims were children and, in most of the cases, burn injuries included the head andboth hands. These results were in agreement with the find ings ... ings of our study. The length of hospital stay and the mortality increased with increases in extent of the burnarea. In our case, the 2 patients who died had over 30%TBSA burns.Epilepsy in 5 ... located is the region of Turkey with the lowest socioeconomic level and the area also has very cold winter days. A substantial num-ber of people living in these provinces provide their heat-ing and...

Báo cáo y học: " Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll-like receptors" ppsx

... occur in the setting of infection, and it is possible that the primary geneticlesions in autoimmunity involve components of the samesystem that induces cytokine production in the course of aninfection. ... observed in septic shock. In part, they do so bytriggering the release of many secondary cytokines, includ-ing IL-6, and numerous chemokines, which may further con-tribute to the septic syndrome.It ... within the past4 years in our understanding of how cytokine storm is elicitedduring severe infection offer a good deal of promise. Althoughsuccess in treating sepsis with individual cytokine inhibitorshas...

Báo cáo y học: "Clinical review: Intra-abdominal hypertension: does it influence the physiology of prone ventilation" doc

... report ing, or stratifying by either IAP or BMI.Abdominal morphologyAbdominal morphology intuitively plays a central role in a technique involving positioning the critically ill patient upon their ... likely to greatly in uence respiratory mechanics and outcomes. Further study of the role of IAP/IAH in the physiology and outcomes of PV in hypoxemic respiratory failure is thus required. Theories ... pulmonary and extrapulmonary – reﬂ ecting either direct lung injury or indirect injuries to the pul monary endothelium as mediated by the systemic in am matory response [20,21]. In particular, the...

Báo cáo Y học: Two 1 : 1 binding modes for distamycin in the minor groove of d(GGCCAATTGG) docx

... asoutcomes of such calculations may be spoiled by inaccuratepositioning of the interacting groups. The contact area of the distamycin amidinium end wasinvestigated by evaluating the hydrogen positions ... between the pyrrole rings form bifurcated hydrogen bonds with the thymine or adenine bases. The central N5(D) atom of the drug is hydrogen-bonded to the two O2 atoms of the thymine bases of the central ... one crystal the distamycin orientation and binding site is the same as in 12-dista, the orientation of the drug is inverted in the other crystal. Both orientations show interactions betweenthedrugandguanineNH2groups....

Báo cáo y học: "Familial Polycythemia Caused by a Novel Mutation in the Beta Globin Gene: Essential Role of P50 in Evaluation of Familial Polycythemi" potx

... in any other peaks suggesting a mutation somewhere in the core. 4. Conclusion Family history of polycythemia in a subject with polycythemia should raise the suspicion for the presence of ... affecting this interface. All these substitutions can affect the cooperative nature of oxygen binding with heme, and in turn, can change the affinity of Hb for oxygen. The majority of mutations ... other symptoms. Past medical history was unremarkable. Family history was significant for lifelong history of polycythemia in her mother, maternal grandmother and her younger sister. Physical...

Báo cáo y học: "Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age: Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes" pot

... by the age-associated increases in the staining of thymocytes and microenvironmental cells, including the multilocular fat-storing cells. These data suggest that chemokines may influence the ... inflammatory cytokines including LIF, IL-1, IL-6, TNF-α among others (43, 44). In the thymus, we have observed an increased level of LIF, IL-6, TNF-α and other pro-inflammatory cytokines in the supernatant ... Within the young thymus, several cell types have been described as playing a role in thymic physiology including thymocytes, thymic epithelial cells, dendritic cells, fibroblasts, mesenchymal...

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