Báo cáo y học: "RNA interference: more than a research tool

Báo cáo y học: "RNA interference: more than a research tool in the vertebrates'''' adaptive immunity" ppsx

... this regulatory function has transformed our thinking on the role of RNA in many facets of biology, illustrating the complexity and the dynamic interplay of cellular regulation. As plants and invertebrates ... some of the mam- malian virus-encoded proteins, such as influenza viral protein NS1 and vaccinia viral protein E3L, have a nega- tive regulatory role on RNA silencing in b...

Ngày tải lên : 13/08/2014, 09:21

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Báo cáo y học: "RNA interference against polo-like kinase-1 in advanced non-small cell lung cancers" doc

... 61:850-862. 14. Ochiya T, Takahama Y, Nagahara S, Sumita Y, Hisada A, Itoh H, Nagai Y, Terada M: New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: the Minipellet. Nat Med 1999, 5:707-710. 15. Song ... liver metastases of lung cancer. Mol Cancer Ther 2008, 7:2904-2912. 52. Nogawa M, Yuasa T, Kimura S, Tanaka M, Kuroda J, Sato K, Yokota A, Segaw...

Ngày tải lên : 10/08/2014, 09:22

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Báo cáo y học: "RNA interference pinpoints regulators of cell size and the cell cycle" doc

... proteins. The insulin signaling pathway leading to activation of the protein kinase Tor is a well known regulator of growth and can alter cell size in both Drosophila and mammals [10]. Activating ... short interfering RNAs (siRNAs). Second, there are significantly fewer genes in Drosophila than in mammals, making the mammoth undertaking of a genome- wide screen a little le...

Ngày tải lên : 14/08/2014, 16:21

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Báo cáo y học: "Familial Polycythemia Caused by a Novel Mutation in the Beta Globin Gene: Essential Role of P50 in Evaluation of Familial Polycythemi" potx

... polycythemia in her mother, maternal grandmother and her younger sister. Physical examination was unremarkable. Laboratory parameters were remarkable for elevated hemoglobin (17.2 gm%) and ... level. In a polycythemic patient, establishing a correct diagnosis of a high affinity Hb variant is important as these patients have normal life expectancy and do not require phlebotomy...

Ngày tải lên : 08/08/2014, 16:23

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Báo cáo y học: "Open Access Torsion of a normal ovary in the third trimester of pregnancy: a case report" docx

... contributions AS was involved in the management of the case and wrote the manuscript draft. VG conducted the literature research and revised the manuscript. References 1. Bayer AL, Iskind AK: Adnexal torsion: ... is hampered by non-specific symptoms common in pregnancy. Early diagnosis is essential as it facilitates a con- servative approach. When diagnosis is made early a...

Ngày tải lên : 11/08/2014, 19:21

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Báo cáo y học: " Is canalization more than just a beautiful idea" pps

... endogenous small interfering RNA (esiRNA) pathway of RNA silencing restrains the expression of transposons in somatic cells, whereas the piRNA pathway represses transposon activity in germline cells. Transposons ... play a role in the biogenesis of small silencing RNAs either as a chaperone for the correct folding of the Argonaute proteins or by providing an assembly...

Ngày tải lên : 09/08/2014, 20:21

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Báo cáo y học: "RNA interference of argininosuccinate synthetase restores sensitivity to recombinant arginine deiminase (rADI) in resistant cancer cells" pps

... poor responses indicate that there are obstacles to the clinical application of rADI in cancer therapy. Argininosuccinate synthetase (AS), a rate-limit ing enzyme in the citrulline-arginine regeneration pathway, has ... argininosuccinate synthetas e arginine deiminase , resistance, RNA interference Background Arginine deiminase depletes arginine by hydrolyzing it to ci trulline. Peg...

Ngày tải lên : 10/08/2014, 05:21

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Báo cáo y học: "RNA interference for CFTR attenuates lung fluid absorption at birth in rats" doc

... 5'- GCTTTTCCAAAAAATGGAGAGATGAAGAAATAT- TCTCTTGAAATATTTCTTCATCTCTCCACG-3'; pSi-C 2 , forward 5'- ATCCGAAAGTATATGTACCAAGATTCAAGAGATCTTGG- TACATATACTTTCTTTTTTGGAAA-3', pSi-C 2 , reverse 5'- AGCTTTTCCAAAAAAGAAAGTATATGTACCAA- GATCTCTTGAATCTTGGTACATATACTTTCG-3'. ... 5'- GATCCGTTACACTATTAACAACAAATTCAAGAGATTT- GTTGTTAATAGTGTAATTT TTTGGAAA-3', pSi-4, reverse: 5-...

Ngày tải lên : 12/08/2014, 15:21

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Báo cáo y học: "RNA interference: a multifaceted innate antiviral defense Ajit Kumar" ppsx

... affect the stability or subcellular localization or miRNA target specificity. We are at the early stages of appreciating the influence of structural domains in miRNA that influence its functional ... mRNAs. Thirdly, in another viral system, the hepatitis C virus (HCV), cellular miRNAs are apparently a component of the down stream antiviral effectors of the interferon respons...

Ngày tải lên : 13/08/2014, 06:20

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Báo cáo y học: "RNA interference has a role in regulating Drosophila telomeres" potx

... HeT -A is significantly more abundant than TART in the genomes of stocks that have been examined (P.G. DeBaryshe, personal communication). The predominance of HeT -A has always been puzzling, because ... telomeres have many functions, yet we understand little about how they actually accomplish any of them. The RNA interference machinery affects telomere elongation in Drosophil...

Ngày tải lên : 14/08/2014, 16:21

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Báo cáo y học: "RNA interference: more than a research tool in the vertebrates'''''''' adaptive immunity" ppsx