Báo cáo y học: "Mutation in the loop C-terminal to the cyclophilin A binding site of HIV-1 capsid protein disrupts proper virus assembly and infectivity" ppt
... on x-ray crystallographic data, NMR and in
vitro assembly models, the importance of major homol-
ogy region [10], the binding site for cyclophilin A (CypA)
[11,12], and the CA dimer interfaces ... proper CA cone formation and mutations in
CA are lethal when they inhibit CA assembly by destabilizing the intra and/ or inter molecular CA
contacts, which ultimat...
... degree and rapidity of change of vascular
tone and compliance, and the geometry of the arterial
system can all a ect APCO algorithms, making these
systems unreliable in patients undergoing rapid ... is
Abstract
The accuracy of the arterial pressure-based cardiac
output FloTrac-Vigileo system remains unacceptably
low during haemodynamic instability. Data show tha...
...
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1325-1340.
6. Haun C, Alexander J, Stainier DY, Okkema PG:
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hheeaarrtt ... manner, the authors
examined an event downstream of TF recruitment - the place-
ment of the basal transcriptional machinery. They did this by
chromatin immunoprecipitati...
... Martinez A, Mayer K, Anderson DJ: Detection of
human immunodeficiency virus type 1 in semen from serop-
ositive men using culture and polymerase chain reaction
deoxyribonucleic acid amplification ... indinavir to their ART regimen. This study is important
because it provides a new tool for studying HIV infection
of the male genital tract, and provides preliminary evi-
dence...
... design, data analysis and drafting of the
manuscript. All authors read and approved the final draft.
Competing interests
The authors declare that they have no competing interests.
Received: 6 October ... evaluated using
the MTT [1-(4,5-dimethylthiazol-2-yl)-3,5-diphenylfor-
mazan] assay and histology.
Rabbit Rectal Irritation Study
A ten day repeat dose toxicology study in...
... access to all of the study data and takes responsibility for
the integrity of the data and the accuracy of the data analysis. Both authors
contributed equally to the study. Study concept and design: ... Universidad de Valladolid. Avenida
Ramón y Cajal 3. 47005. Valladolid. Spain.
4
Department of Anaesthesiology
and Reanimation. Hospital Universitario Rio Hort...
... image of the fracture of the forearm shaft and distal radius. (B) Image of the fracture of the fore-
arm shaft and distal radius after fixed-plate osteosynthesis. (C) Image of the fracture after ... the blast
wave or hurtling parts can induce long intimal tears that
may require a secondary adventitectomy or venous inter-
position grafts.
(A) Image of the volar...
... 83% later assigned to stand-
ard care. Intracoronary thrombolysis was used in 42% of
patients later randomized to IABP therapy compared to
46% of patients in the standard therapy arm. Intravenous
heparin ... randomized
patients at the end of initial coronary angiography to 48 h
of prophylactic IABP therapy (n = 23) or standard care (n
= 22). The primary endpoint was...
... [1-4],
including the study by Kolhe and colleagues [1] in Critical
Care. Interestingly, as facts about AKI and its impact on prog-
nosis emerged, areas of uncertainty and controversy became
apparent ... several areas in the field of AKI remain
uncertain, the issue of RRT being a particularly controversial
one [5]. There is wide variation in clinical practice regardin...
... respiratory failure. Many
ECMO candidates have an increased inflammatory response
with capillary leakage before the start of ECMO because of
asphyxia, hypoxia and shock. ECMO treatment in itself ... or aggravate a systemic inflammatory response (SIRS),
resulting in a so-called capillary leakage syndrome [1]. High
levels of circulating endotoxins, exotoxins, interleukins and...