Báo cáo y học: " Human TRIM5α mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants Patrick Kaumanns, Isabel Hagmann and Matthias T " pps
Báo cáo y học: " Human TRIM5α mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants Patrick Kaumanns, Isabel Hagmann and Matthias T " pps
... purposes)RetrovirologyOpen AccessShort report Human TRIM5α mediated restriction of different HIV-1 subtypes and Lv2 sensitive and insensitive HIV-2 variants Patrick Kaumanns, Isabel Hagmann and Matthias T Dittmar*Address: ... study it is tempting to speculate that they might notonly be restricted by TRIM5α but also by Lv2 or yetanother unknown restriction factor, as we could show inthis study that both TRIM5α and ... to restrict HIV-1 infectionquite substantially but that the restriction due to TRIM5α is entry route independent (VSV-G versus HIV-1 enve-Retrovirology 2006, 3:79 http://www.retrovirology.com/content/3/1/79Page...
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Báo cáo y học: " Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IκBα and enhances HIV-1 replication in human T lymphocytes" ppsx
... activelyexported to the cytosol and thereby permitting a sustainedNF-κB-dependent activity by free p65wt. The active shut-tling of ΔNH2p65 from the nucleus to the cytosol wouldexplain why it largely ... transactivation and ultimately leads toapoptosis. Therefore, caspase-3-related proteolysis maydetermine the duration of NF-κB activity in stimulated T cells and may play a critical role in the ... out by co-transfection of the pSV-β-Galactosidase vector. Data correspond to the mean of three different experiments and lines on the top of the bars represent the standard deviation. (b) Two...
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Báo cáo y học: "The contact-mediated response of peripheral-blood monocytes to preactivated T cells is suppressed by serum factors in rheumatoid arthritis" ppt
... indicatethat the inhibitory effect of RA sera is evident only in patientswith active disease. To explore the disease specificity of thisinhibitory activity further, sera from patients with ankylosingFigure ... levels.The present results confirm that patients with RA do not havean increased serum concentration of ApoA-1 compared withthat of healthy controls. Consequently, the strong inhibitoryactivity of ... was treatedwith etanercept.To explore the influence of clinical parameters of the diseaseon inhibitory serum activity, two additional patient cohortswere recruited. Twenty patients with non-active...
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Báo cáo y học: "Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy" ppsx
... weevaluated the potential of apoptotic cell injection to influence thecourse of inflammation in SCW-induced arthritis in rats.Methods Rat apoptotic thymocytes were injectedintraperitoneally (2 ... efficient to induce and sustain SCW inflammation.Indeed, apoptotic cell injection acts in two different ways. First,apoptotic cells together with phagocytes that digest apoptoticcells in a very ... arthritis by macrophageactivation prevention and regulatory T cells increase. (a) Rats from the different groups were punctured into the retro-orbital sinus at day 1 to quantify circulating total...
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Báo cáo y học: " Human embryonic stem cell (hES) derived dendritic cells are functionally normal and are susceptible to HIV-1 infection" pot
... adaptive immunity, DCs constitute the most pow-erful antigen presenting cells (APCs) that prime naïve T lymphocytes and sensitize cytotoxic T lymphocytes to theantigens they present [13]. Thus, ... addi-tion, they are tractable for stable genetic modification.These attributes qualify them as potential candidates toderive an unlimited supply of any cell type for transplan-tation, gene therapy, ... Research and Therapy 2008, 5:1 http://www.aidsrestherapy.com/content/5/1/1Page 2 of 9(page number not for citation purposes)demonstrated the ability of hES cells to differentiate intoa myriad of...
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Báo cáo y học: "Human cardiac tissue in a microperfusion chamber simulating extracorporeal circulation ischemia and apoptosis studies" docx
... interpreted as limitation of the present study. Our future perspectives are to widenthe research on other drugs with potential anti-apopto-tic effect. Another limitation is that i n this study ... evaluation and participated in the study design and coordination. EU performed thestatistical analysis. MR and MM participated in the experiments and dataevaluation. HA and GZ conceived of the study, ... with the concentration employed in this study,apoptotic events could be inhibited considerably.Furthermore the primary purpose of this stud y was totest the principle of b-blockade on apoptotic...
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Báo cáo y học: "Human endogenous retrovirus-FRD envelope protein (syncytin 2) expression in normal and trisomy 21-affected placenta" doc
... progenitors, the withdrawal of cytotro-phoblasts from the cell cycle to G0, the recruitment of these post-mitotic cells to syncytiotrophoblast after mem-brane fusion and progression of syncytiotrophoblasttowards ... showed the con-tinuity of syncytin 2 immunostaining between thecytoplasm surrounding the nuclei and that of the thinelongated cytoplasmic processes.Syncytin 2 immunostaining of cytotrophoblastic ... F. This large magnification allows to clearly establish the syncytin 2 immunostaining continuity within cytotro-phoblasts between the cytoplasm surrounding the nuclei and that of the thin cytoplasmic...
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Báo cáo y học: "Human embryonal epithelial cells of the developing small intestinal crypts can express the Hodgkin-cell associated antigen Ki-1 (CD30) in spontaneous abortions during the first trimester of gestation" ppsx
... 2Department of Pathology, Ippokration Hospital of Salonica, Greece, 3Department of Histology – Embryology, Democritus University of Thrace, Greece and 4Department of Obstetrics and Gynecology, ... does not necessarilyrelate Hodgkin and R-S cells to activated lymphocytes.The identification of this antigen in cells as apparently dis-parate as activated lymphocytes, R-S cells and now human epithelial ... stroma.Table 1: Expresion of CD30 antigen in fetal intestinal cryptae cells during the first trimester of gestation.Spontaneous abortions Voluntary abortions8th week 10th week statistics 8th week...
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Báo cáo Y học: The cold-active lipase of Pseudomonas fragi Heterologous expression, biochemical characterization and molecular modeling pdf
... assay, rPFL displayedhighest activity at 29 °C and pH 8.0, in good agreementwith results reported for the wild type enzyme [30].Interestingly, the enzyme lost most of its activity at 50 °Cbut ... hypothesis that PFL might be secreted by asignal peptide-independent pathway and calls for furtherinvestigation on this subject.Enzyme activity and specificityIn the standard tricaprylin hydrolysis ... biotechnologicalexploitation based on their high catalytic activity at lowtemperatures, low thermostability and unusual specificities.These properties are of interest in different fields such asdetergents, textile...
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Báo cáo y học: "Pain as a symptom of peripheral nerve sheath tumors: clinical significance and future therapeutic directions" potx
... Management of extremitysoft tissue sarcomas with limb-sparing surgery and postoper-ative irradiation: do total dose, overall treatment time, and the surgery-radiotherapy interval impact on local ... summary of what is currently known is the topic of the present review.Pain as a presenting symptom of peripheral nerve tumors Of clear importance is the ability to differentiate betweenbenign and ... presentation,diagnosis and management. Further, little is known regarding the pathogenesis of these tumors,how they cause symptoms, and how to treat these symptoms. One classic symptom of peripheralnerve...
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